Development of Colon Delivery Tablets of Albendazole using pH-Dependent Polymers

DOI:

https://doi.org/10.37285/ijpsn.2013.6.4.4

Authors

  • Kansagara Hetal
  • Bhagat Shreel
  • Sudarshan Singh

Abstract

Albendazole is a banzimidazole derivative with broad spectrum anthelmentic activity and excellent tolerability. Albendazole was selected for colon delivery because the colon is the major site of residence for several types of worms and only a very small amount of drug reaches the colon after oral administration. The objective of this work was to deliver Albendazole to colon by coating it with various pH dependent polymers and plasticizers. The formulations were prepared with lactose monohydrate by wet granulation method using Starch paste and coated with pH dependent polymers and plasticizers. The prepared tablets were evaluated for hardness, friability, drug content and in vitro dissolution. Among all formulations, Eudragit S100 coated tablets showed the best outcome to protect the drug in stomach environment as compare to CAP. Tablets coated with 8% Eudragit S100 showed 98.08% drug release within 12 hr. These findings indicate the potential viability using pH dependent polymers for colon specific drug delivery. 

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Keywords:

Albendazole, pH dependent polymers, Eudragit S100, CAP

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Published

2013-12-31

How to Cite

1.
Hetal K, Shreel B, Singh S. Development of Colon Delivery Tablets of Albendazole using pH-Dependent Polymers. Scopus Indexed [Internet]. 2013 Dec. 31 [cited 2024 Jun. 20];6(4):2219-24. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/684

Issue

Section

Research Articles

References

Akhgari F, Sadeghi H and Garekani A (2006). Combination of time-dependent and pH-dependent polymethacrylates as a single coating formulation for colonic delivery of indomethacin pellets. Int J Pharm 22: 137–142.

Chauhan CS, Naruka PS, Rathore RS and Badadwal V (2010). Formulation and evaluation of Prednisolone tablet for colon targeted drug delivery system. J Chem Pharma Res 3: 993-998.

Choudhury PK, Murthy PN, Tripathy NK, and Patra S (2012). Formulation design and development of enteric coated matrix tablets of Ornidazole for colonic delivery. Asian J Pharma Edn Res 2: 86-89.

Khokra, SL, Parashar B, Dhamija HK, Purohit R and Chandel A (2012). Formulation development and evaluation of chewable tablet of Albendazole by different techniques. Int J Pharm Pharma Sci 2: 461-464.

Krishnaiah YSR, Raju V, Kumar D, Bhaskar P and Satyanarayana V (2001). Development of colon targeted drug delivery systems of Mebendazole. J Cont Rel 12: 87-95.

Martindale (2005). The Complete Drug Reference 34th Edition. The Pharmaceutical Press, USA, vol-1, p. 139-140

Panchal A, Chourasiya DK, Patel SS and Mishra S (2012). Formulation and evaluation of enteric coated tablets of metronidazole for colonic drug delivery. Asian J Pharma Edn Res 3: 76-90.

Patel TD, Patel DM, Patel CN, Parikh BN and Gothi GD (2010). Formulation and development of enteric coated pH dependent compression coated tablets of Mesalamine. J Global Pharm Tech 2(6): 118-124.

Sharma M, Joshi B, Bansal M and Goswami M (2012). Formulation and evaluation of colon targeted tablets of mesalazine. J Drug Delivery Therap 5: 24-36.