Formulation of Oral Mucoadhesive Tablets of Pioglitazone using Natural Gum from Seeds of Pithecellobium Dulce

DOI:

https://doi.org/10.37285/ijpsn.2015.8.4.6

Authors

  • Sudarshan Singh
  • Hitesha Goswami

Abstract



The plant derived gums and mucilage’s comply with many requirements of pharmaceutical excipients as they are non-toxic, stable, easily available, associated with less regulatory issues as compared to their synthetic counterpart and inexpensive; also these can be easily modified to meet the specific need. The present study was undertaken to isolate mucilage from the seeds of Pithecellobium dulce (P. dulce). The mucilage isolated from P. dulce were used as a bioadhesive polymer in tablet formulation and evaluated for the parameters such as swelling, pH, and bioadhesive property like bioadhesive strength, and ex-vivo residence time. The oral mucoadhesive tablets were prepared using Pioglitazone as model drug and P. dulce seeds mucilage as mucoadhesive polymer. The prepared tablets were evaluated against existing mucoadhesive polymer such as Xanthan gum and Hydroxyl Propyl Methyl Cellulose K4M to explore its use as Pharmaceutical excipients. Swelling index of P. dulce was found to be 87.46 ± 0.11 % which was higher than Xanthan gum but lower than HPMC K4M having swelling index 73.28 ± 0.01 % and 98.88 ± 0.03 % respectively. The results showed that Bioadhesion strength of P. dulce was found to be 50.86 ± 0.03N which was higher than HPMC K4M but lower than Xanthan gum having Force of adhesion 32.81 ± 0.04N and 57.17 ± 0.01N respectively. The percentage cumulative drug release drug release of optimize batch F8 was found to be 101.71 %. So, it was concluded that the mucilage of P. dulce can be used as a pharmaceutical excipient in oral bioadhesive drug delivery systems.

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Keywords:

Pithecellobium dulce, Natural mucoadhesive polymer, Pioglitazone

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Published

2015-11-30

How to Cite

1.
Singh S, Goswami H. Formulation of Oral Mucoadhesive Tablets of Pioglitazone using Natural Gum from Seeds of Pithecellobium Dulce. Scopus Indexed [Internet]. 2015 Nov. 30 [cited 2024 Dec. 11];8(4):3031-8. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/810

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Section

Research Articles

References

Asha S and John D (2010). Development and evaluation of buccoadhesive drug delivery system for Atorvastatin calcium. J Current Pharma Res, 125: 31-38.

Aulton ME (2007). In: Pharmaceutics-The design and manufacture of medicines. London New York: Churchil Livingstone, pp 126.

Avachat AM, Dash RR and Shrotriya SN (2011). Recent Investigations of Plant Based Natural Gums, Mucilages and Resins in Novel Drug Delivery Systems. Indian J Pharm Edu Res, 45(1): 86-99.

Banerjee T and Venkateswarlu BS (2011). Formulation and evaluation of mucoadhesive tablets of NSAID combination with proton pump inhibitor. Int J Pharm Res Dev, 3(8): 160- 169.

Chowdary KP and Reddy GK (2003). Design and evaluation of Diltiazem mucoadhesive Tablets for oral controlled release. Saudi Pharm J, 11(4): 201-205.

Indian Pharmacopoeia (2007). Govt. of India, Ministry of Health & Family Welfare, Ghaziabad: Indian Pharmacopoeia Commission, pp 714.

Jeevanandham, Dhachinamoorthi D, Senthil V and Chandra KB (2010). Fabrication and evaluation of oral tablets using natural mucoadhesive agent from seeds of Caesalpinia pulcherrima, Asian J Pharm, 4(2): 135-140.

Khanzada SK, Khanzada AK and Ali SA (2013). Phytochemical studies on Pithecellobium dulce benth. A medicinal plant of sindh, Pakistan. Pak J Bot, 45(2): 557-561.

Patel VF and Brown MB (2011). Advances in oral Transmucosal drug delivery. J Cont Re, 153:106-116.

Paul Y and Rahul S (2012). Design, development and characterization of mucoadhesive tablets of Atenolol. Int J Pharm Bio Sci, 3(1): 383-395.

Rajput GC, Majmudar FD, Patel JK, Patel KN, Thakor RS, Patel BP and Rajgor NB (2010). Stomach Specific Mucoadhesive Tablets As Controlled Drug Delivery System. Int J Pharm Bio Res, 1(1): 30-41.

Rao GN (2013). Physico-Chemical, Mineral, Amino Acid Composition, in vitro Antioxidant Activity and Sorption Isotherm of Pithecellobium dulce L. Seed Protein Flour. J Food Pharma Sci, (1): 54-60

Ravindran VK and Rao YM (2012). Comparative study of mucoadhesive polymers carbopol 974p and sodium carboxymethyl cellulose for single unit dosage of imatinib mesylate. Malaysian J Pharma Sc, 10(1): 61-77.

Singh S and Singh S (2010). Preliminary Investigation of Cassia Sophera Linn Seed Mucilage in Tablet Formulations. Int J Pharm Applied Sci, 112: 62-68.

Yash P, Kumar S and Sehrawat R (2012). Design, Development and Characterization of Mucoadhesive tablets of Atenolol, Int J Pharma Bio Sci, 96: 383-399.

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