Preparation and Evaluation of Spray Dried Mucoadhesive Microspheres of Metoclopramide Hydrochloride for Nasal Delivery

DOI:

https://doi.org/10.37285/ijpsn.2013.6.1.12

Authors

  • Galgatte U C
  • Kirange R H
  • C W Pote
  • D A Thanvi
  • P D Chaudhari

Abstract



There is increasing interest in drug delivery through nasal mucosa because of the ability of drug particles to cross membrane due to their particle size in nano or submicron range. The present study was aimed to prepare and evaluate microspheres of metoclopramide hydrochloride (MH) by using HPMC E4M and Carbopol 934P. Microspheres were prepared using spray drying method and particle size was found in the range of 1.62 µm. Drug loaded microspheres of HPMC E4M and Carbopol 934P and combination of HPMC E4M: Carbopol 934P were evaluated for various parameters for optimized batch were drug entrapment (61.73%), mucoadhesive strength (1959.30 g/cms2), and in-vitro diffusion studies (95.61%). Optimized batch also evaluated for SEM, TEM, X-ray diffraction study. Amorphous form of optimized batch was confirmed by X-ray diffraction study. Particles were spherical and discrete confirmed by SEM study. Particle size range was confirmed by TEM. The drug release of optimized batch was carried out by using sheep nasal membrane. Histopathological studies have shown no toxicity to the sheep nasal membrane and hence optimized formulation was found to be safe. The optimized formulation was found to be stable in the accelerated stability studies. It was found that drug entrapment was in the order of HPMC E4M> Carbopol934P > Carbopol 934P: HPMC E4M, mucoadhesive strength Carbopol 934P: HPMC E4M > Carbopol 934P > HPMC E4M, In-vitro drug release Carbopol 934P: HPMC E4M > HPMC E4M > Carbopol 934P. In conclusion, these studies indicate the feasibility and superior pharmacokinetic profile of the metoclopramide nasal system.

 

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Keywords:

Metoclopramide, Spray drying, Nasal delivery, Mucoadhesion, Microspheres

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Published

2013-05-31

How to Cite

1.
U C G, R H K, Pote CW, Thanvi DA, Chaudhari PD. Preparation and Evaluation of Spray Dried Mucoadhesive Microspheres of Metoclopramide Hydrochloride for Nasal Delivery. Scopus Indexed [Internet]. 2013 May 31 [cited 2024 Jul. 27];6(1):1994-2007. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/613

Issue

Vol. 6 No. 1 (2013): April-June 2013

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Amzallag A, Vaillant C, Jacob M, Unser M, Bednar J, Kahn J, Dubochet J, Stasiak A. and John H. Maddocks (2006). 3D reconstruction and comparison of shapes of DNA minicircles observed by cryo-electron microscopy. Nucleic Acids Research 34: e125.

Bhanu P Sahu and HK Sharma (2011). Nasal delivery of felodopine using hydrogel matrix. J Global Trends Pharma Sci 2: 296-309.

Desai S, Gali Vidyasagar G, Shah V, Desai D (2011). Preparation and in vitro characterization of mucoadhesive microspheres of Midazolam: nose to brain administration, Asian J Pharma Clin Res 4: 100-102.

Fultz B and Howe J (2007). Transmission Electron Microscopy and Diffractometry of Materials. Springer ISBN : 9-15.

Gavini E and Hegg AB (2006). Nasal administration of carbamazepine using chitosan microspheres in vitro / in vivo studies. Int J. Pharma. Sci. 307: 9-15.

Ghosh PK (2006). Thernoreversible- Mucoadhesive gel for nasal delivery of sumatriptan. AAPS Pharm Sci Tech 7: 100-102.

Jadhav KR, Gambhire MN, Shaikh IM, Kadam VJ and pisal SS (2007). Nasal drug delivery system-factors affecting and applications. Current Drug Therapy 2: 27-38.

Jaya Raj Kumar K, Jayachandran E and Srinivas GM (2010). Formulation and evalution of pH–Induced povidone iodine in situ gel for oralthrush. J. Pharm. Sci. & Res. 2(5): 294-301;.

Kavita K and Rajas NJ (2011). Sustained opthalmic delivery of levofloxacin hemihydrate from an ion activated in situ delling system. Int J Pharm Tech Research 3: 702-706.

Krishnamoorthy R and Mitra AK (1998). Prodrugs for nasal drug delivery. Advanced Drug Delivery Rev 29: 135-46.

Mahajan H, Gattani S and Surana S (2008). Spray dried mucoadhesive microspheres of ondansetron for nasal administration. Int J Pharma Sci Nanotech 1: 267-274.

Mainardes RM, Cocenza urban MC, Cinto PO, Chaud MV and Evangelista RC et al (2006). Liposomes and micro / nanoparticles as colloidal carriers for nasal drug delivery. Curr Drug Delivery 3: 275-85.

Mao S, Chen J, Wei Z, Liu H, and Dianzhou B (2004). Intranasal administration of melatonin starch microspheres. Int J Pharma 272 : 37-43;.

Martin A, Bustamante P and Chun AH, Eds (1996). Physical pharmacy, 4th Edn, B.J. Waverly Pvt. Ltd; New Delhi 423-432.

Martinac A and Pavelic A (2005). Spray dried Chitosan / Ethyl cellulose microspheres for nasal drug delivery: swelling studt and evaluation of in vitro drug release properties. J. Microencapsul 5: 549-561.

Mitchell AG (2011). Polymorphism in metoclopramide hydrochloride and metoclopramide. J Pharm Pharmacol 37: 601-604.

Rathan M and, Kumar DS, Shirwaikar A, Ravi Kumar D, Sampath Kumar and Prasad RS (2007). Preparation of mucoadhesive microspheres for nasal delivery by spray drying. Ind J Pharma Sci 69: 651-657.

Soane RJ, Frier M, perkins AC, Jones NS, Davis SS et al (1999). Evaluation of the clearance characteristics of bioadhesive systems in humans. Int J pharma 178: 55-65.

Swamy NGN and Abbas Z (2012). Preparation and in vitro characterization of mucoadhesive polyvinyl alcohol microspheres containing amlodipine besylate for nasal administration. Ind J of Pharm Edun Res 46: 52-58.