Formulation Development of Aceclofenac Loaded Nanosupension by Three Square (32) Factorial Design

DOI:

https://doi.org/10.37285/ijpsn.2011.4.4.9

Authors

  • Atul A Patak
  • Jorwekar, P
  • P D Chaudhari

Abstract



In the present study, aceclofenac loaded polymeric nanosuspension were formulated and evaluated.  Aceclofenac is a potent analgesic under BCS Class II. Due to the need for its frequent dosing, aceclofenac is an ideal candidate for sustained or controlled drug delivery. For optimization of prepared formulation, the three square (32) factorial design was used.  Tween 80 (X1) and combination of Eudragit RL 100 and RS 100 (X2) were used as independent variables and particle size (Y1), entrapment efficiency (Y2), and Percent drug release (Y3) were taken as dependent variables. The formulations were evaluated for particle size, zeta potential and drug entrapment. The in vitro drug release profile supports nanosuspension form to be used as a sustained release vehicle for aceclofenac. The formulation was characterized by differential scanning calorimetric analysis, in vivo studies and stability testing.

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Keywords:

Aceclofenac, nanosuspension, particle size, factorial design

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Published

2012-02-29

How to Cite

1.
Patak AA, P J, Chaudhari PD. Formulation Development of Aceclofenac Loaded Nanosupension by Three Square (32) Factorial Design. Scopus Indexed [Internet]. 2012 Feb. 29 [cited 2024 Oct. 11];4(4):1575-83. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/468

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Section

Research Articles

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