Scientific and Medical Research on Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Therapy and its Influence on Assisting to Cure or Prevent the Nosocomial Infections, Synergistically Enhancing the Conventional Cancer Therapies, as an Adjuvant,
its Possible Potential to Prevent or Cure COVID-19 Novel Corona Virus Infection by Balancing the Intestinal Microbiota and Microbiome through Modulation of the Human Immune System
DOI:
https://doi.org/10.37285/ijpsn.2020.13.3.3Abstract
The composition and the preparation of Dr. M.S. Reddy’s Multiple Mixed Strain Probiotics along with their growth end products such as immunomodulins, bacteriocins, bio-active peptides, and Nano inhibitory compounds has been presented in a pictorial form. The methodology of carrying on community based clinical trials to prevent or cure nosocomial infections, and to cure cancer when such Multiple Mixed Strain Probiotics are used as adjuvants along with the standard cancer therapies is also presented with explicit details and easy to follow pictorial presentation. A thorough introduction, discussion, and conclusion were presented regarding the efficacy of Dr. M.S. Reddy’s Multiple Mixed Strain probiotic adjuvant cancer therapy to assist the standard cancer therapies including the immune checkpoint therapy etc. using pictorial presentation. A detailed scientific explanation has been given regarding how Multiple Mixed Strain probiotics and their growth end products can perform as cancer curing peptides, immune checkpoint inhibitors, undefined chemotherapeutic agents, gene therapeutic agents, targeted therapeutic agents, and hormonal therapeutic agents. In addition, solid scientific hypothesis has also been presented with regard to how Dr. M.S. Reddy’s Multiple Mixed Strain Probiotics can prevent or cure the deadly disease COVID-19 caused by Novo Coronavirus (SARS – CoV-2). Conclusive remarks include the absolute necessity of using Multiple Mixed Strain probiotic adjuvant cancer therapy as a universal base adjuvant therapy along with any chosen conventional cancer therapy, to effectively cure cancer with least side effects and relapse.
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Keywords:
Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Therapy, Immune Checkpoint Therapy, Dr. M.S. Reddy’s Multiple Mixed Strain Adjuvant Cancer Therapy;, Nosocomial Infections, Novel Coronavirus, COVID-19, Traditional Cancer Therapies, C. diff, MRSA, Dysbiosis, Microbiota, Microbiome, Autoimmune Diseases, T-Regulatory Cells, SARS-CoV-2
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Published
2020-05-31
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1.
Reddy MS. Scientific and Medical Research on Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Therapy and its Influence on Assisting to Cure or Prevent the Nosocomial Infections, Synergistically Enhancing the Conventional Cancer Therapies, as an Adjuvant,: its Possible Potential to Prevent or Cure COVID-19 Novel Corona Virus Infection by Balancing the Intestinal Microbiota and Microbiome through Modulation of the Human Immune System. Scopus Indexed [Internet]. 2020 May 31 [cited 2024 May 18];13(3):4876-90. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/928
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Research Articles
References
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Koliada A, Syzenko G, Moseiko V, Budovska L, Puchkov K, Perederiy V, Gavalko Y, Dorofeyev A, Romanenko M, Tkach S, Sineok L, Lushchak O, Vaiserman A (2017). Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. 17: 120-130. DOI: 10.1186/s12866-017-1027-1.
Leach DR, Krummel MF, and Allison JP (1996). Enhancement of antitumor immunity by CTLA-4 blockade. Science 271(5256): 1734-1736.
Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI (2005). "Obesity alters gut microbial ecology." Proc. Natl Acad. Sci. USA. DOI: 10.1073/pans.0504978102.
Ley RE, Peterson DA, and Gordon JI (2006). Ecology and evalutionary forces shaping microbial diversity in the human intestine. Cell. DOI: 10.1016/ J. Cell. 2006.02.017.
Lum GR, Olson C, and Hsiao E (2019). Emerging roles for the intestinal microbiome in epilepsy. Neurobiology of Disease 135: 104576. DOI: 10.1016/j.nbd.2019.104576.
Markova NV and Hsiao E (2016). Immune dysfunction in autism spectrum disorder. DOI: 10.106/ B978-0-12-800109-7. 00005-4.
Reddy MS (2017). Chronic Stress – An Etiological Agent for the Gensis of Multitude of Diseases, and the Effect of Meditation on Modulating the Stress. Open Acc J of Toxicol. 1(5): 555-561. DOI: 10.19080/OAJT. 2017.01.555571.
Reddy MS (2017). Importance of Bioavailable Calcium and Other Minerals to Reduce the Calcium Deficiency Symptoms, Aging, and Other Pertinent Diseases. Clin Pharmacol Biopharm 2017 Volume 6 Issue 2: 1-5 https://www.omicsonline.org/open-access/ importance-of-bioavailable-calcium-and-other-minerals-to-reduce-thecalcium-deficiency-symptoms-aging-and-other-pertinent-diseases-2167-065X-1000172.php?aid=93360
Reddy MS (2018). Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Adjuvant Cancer Therapy, to complement immune checkpoint therapy and other traditional cancer therapies, with the least autoimmune side effects through eco balance of human microbiome. International Journal of Pharmaceutical Sciences and Nanotechnology. 11(6): 4295-4317.
http://www.ijpsnonline.com/Issues/116rs1.pdf
Reddy MS (2018). Immunomodulatory effect of “Dr. Reddy’s Multiple Mixed Strain Probiotic Therapy” to cure or prevent hospital acquired (nosocomial) infections due to Clostridium difficile (C. diff), other pathogenic bacteria, and autoimmune diseases. International Journal of Pharmaceutical Sciences and Nanotechnology. 11(1): 3937-3749.
http://www.ijpsnonline.com/Issues/3937_full.pdf
Reddy MS (2019). Genesis, Evaluation and Progression of A Breakthrough Discovery to Efficiently Cure Cancer Through Use of Dr. M.S. Reddy’s Multiple Mixed Strain Probiotics as Adjuvants Along with the Traditional Cancer Therapies, Through Restoration of Healthy and Balanced Intestinal Microbiota and their Microbiome. LOJ Phar & Cli Res 1(5): 107-109. LOJPCR.MS.ID.000121.
https://lupinepublishers.com/pharmacology-clinical-research-journal/pdf/LOJPCR.MS.ID.000121.pdf
Reddy MS (2020). Commonsense ways the dairy industry can address Coronavirus. Mar. 6. 2020, columns at http:// www.cheesemarketnews.com.
Reddy MS (2020). Latest Coronavirus episode of China - it's ramifications and applicable preventative and clinical treatment measures. AAPI (American Association of Physicians of Indian Origin) Journal. Mar. Issue-2020: In Print.
Reddy MS Reddy DRK (2015). A Preventative Medical Approach for Cancer Suppression. AAPI Journal. 06: 36-39
Reddy MS, and Reddy DRK (2011). Anti-aging: Review and Experimental Clinical Study of Bioavailable calcium - Probiotics and their effect on reversing osteopenia, osteoporosis, and other common health conditions. International journal of pharmaceutical sciences and Nanotechnology. Vol. 4. Issue 3. October December: 1436-1444.
https://pdfs.semanticscholar.org/493e/795de0505daa5815047112b85fd85bf299b2.pdf
Reddy MS, and Reddy DRK (2016). Development of multiple mixed strain Probiotics for "Probiotic therapy" under clinical conditions, to prevent or cure the deadly hospital acquired infections due to Clostridium difficile (C. diff) and Methicillin resistant staphylococcus aureus (MRSA). International Journal of Pharmaceutical Sciences and Nanotechnology. Sci. Nanotechnology: Vol 9. Issue 3. May-June: 3256-3281. http://www.ijpsnonline.com/Issues/3256_full.pdf
Reddy MS, and Reddy DRK (2016). Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Therapy. J Pharmaceutic and Nano technol. 4(3): 15-28. http://www.rroij.com/open-access/dr-ms-reddys-multiple-mixed-strain-probiotic-therapy-.pdf
Reddy MS, and Reddy DRK (2016). Isolation and determination of the major principle or causative agent behind the 2016 published breakthrough discovery of Dr. M.S. Reddy's "Multiple Mixed Strain Probiotic Therapy," in successfully treating the lethal hospital acquired infections due to Clostridium difficile (C. diff) and Methicillin resistant staphylococcus aureus (MRSA). International Journal of Pharmaceutical Science and Nanotechnology. Vol. 9. Issue 6. November/December: 3556-3566. http://www.ijpsnonline.com/Issues/3556_full.pdf
Reddy MS, and Reddy DRK (2017). An insight into the 2016 Best Medical award winning breakthrough microbial and Nanotechnology based discovery of Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Therapy, to successfully treat the nosocomial infections. Nano Technol and Nano Sci J. 1(1): 2-5. http://hendun.org/journals/NTNS/NTNS-102.php
Reddy MS, Reddy DRK, and Prasad NAV (2000). Herbal and pharmaceutical drugs enhanced with Probiotics. U.S. patent 6,080,401: 1-48.
https://patents.google.com/patent/US6080401A/en
Rung TC, Olson C, and Hsiao E (2017). Interactions between the Microbiota, immune and nervous systems in health and disease. Nature Neuroscience: 20(2). DOI: 10.1038/nn. 4476.
Schwiertz A, Taras D, Schafer K, Beijer S, Bos NA, Donus C, Hardt PD (2010). Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring). 18: 190-195. DOI: 10.1038/boy.2009.167.
Siven A, Corrales L, Hubert N, William JB, Aquino-Michaels K, and Early ZM (2015). Commercial bifidobacterium promotes anti-tumor immunity and facilitates anti-Pd-L1 efficiency. Science 350(6264): 1084-1089.
Turnbaugh PJ, and Gordon JI (2009). The core gut microbiome, energy balance and obesity. J Physiol. 587: 4153-4158. DOI: 10.1113/ physiology.2009.174136.
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, and Gordon JI (2006). An obesity associated gut microbiome with increased capacity for energy harvest. Nature. 444: 1027-1031. DOI: 10.1038/nature05414.
Wolf KJ, and Lorenz RG (2012). Gut Microbiota and obesity. Curr Obes Rep. DOI: 10.1007/S 12679 - 011 -0001 - 8.
Xu J and Gordon JI (2003). Honor thy symbionts. Proc Natl Acad Sci USA. Sep 2: 100(18): 10452-10459. DOI: 10.1073/pans. 1734063100.
Zhu B, Wang X, and Li L (2001). Human gut microbiome: The second genome of the human body. Protein Cell. DOI: 10.1007/S 1323-010-0093-Z.
Fletcher GF, Grundy SM, and Hayman LL (1998). Obesity: Impact on cardiovascular disease. Circulation. DOI: 10.1161/01.CIR.98. 14.1472.
Hampton T (2018). Gut Microbes May Shape Response to Cancer. Immunotherapy. J AMER MED ASSOC. 319(5): 430-431.
Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, and Minato N (2002). Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 99(19): 12293-12297.
Iwai Y, Terawaki S, and Hanjo T (2004). PD-1 blockade inhibits hematogenous spread of poorly immunogenicity tumor cells by enhanced recruitment of effector T-cells. I think. Immunol. 17(2): 133-144.
Jeanette GM, Barrett MJ, Kinch M, and Gordon JI (2017). Food and Microbiota in the FDA regulatory frame work. Science 357 (6346): 39-40.
Koliada A, Syzenko G, Moseiko V, Budovska L, Puchkov K, Perederiy V, Gavalko Y, Dorofeyev A, Romanenko M, Tkach S, Sineok L, Lushchak O, Vaiserman A (2017). Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. 17: 120-130. DOI: 10.1186/s12866-017-1027-1.
Leach DR, Krummel MF, and Allison JP (1996). Enhancement of antitumor immunity by CTLA-4 blockade. Science 271(5256): 1734-1736.
Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI (2005). "Obesity alters gut microbial ecology." Proc. Natl Acad. Sci. USA. DOI: 10.1073/pans.0504978102.
Ley RE, Peterson DA, and Gordon JI (2006). Ecology and evalutionary forces shaping microbial diversity in the human intestine. Cell. DOI: 10.1016/ J. Cell. 2006.02.017.
Lum GR, Olson C, and Hsiao E (2019). Emerging roles for the intestinal microbiome in epilepsy. Neurobiology of Disease 135: 104576. DOI: 10.1016/j.nbd.2019.104576.
Markova NV and Hsiao E (2016). Immune dysfunction in autism spectrum disorder. DOI: 10.106/ B978-0-12-800109-7. 00005-4.
Reddy MS (2017). Chronic Stress – An Etiological Agent for the Gensis of Multitude of Diseases, and the Effect of Meditation on Modulating the Stress. Open Acc J of Toxicol. 1(5): 555-561. DOI: 10.19080/OAJT. 2017.01.555571.
Reddy MS (2017). Importance of Bioavailable Calcium and Other Minerals to Reduce the Calcium Deficiency Symptoms, Aging, and Other Pertinent Diseases. Clin Pharmacol Biopharm 2017 Volume 6 Issue 2: 1-5 https://www.omicsonline.org/open-access/ importance-of-bioavailable-calcium-and-other-minerals-to-reduce-thecalcium-deficiency-symptoms-aging-and-other-pertinent-diseases-2167-065X-1000172.php?aid=93360
Reddy MS (2018). Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Adjuvant Cancer Therapy, to complement immune checkpoint therapy and other traditional cancer therapies, with the least autoimmune side effects through eco balance of human microbiome. International Journal of Pharmaceutical Sciences and Nanotechnology. 11(6): 4295-4317.
http://www.ijpsnonline.com/Issues/116rs1.pdf
Reddy MS (2018). Immunomodulatory effect of “Dr. Reddy’s Multiple Mixed Strain Probiotic Therapy” to cure or prevent hospital acquired (nosocomial) infections due to Clostridium difficile (C. diff), other pathogenic bacteria, and autoimmune diseases. International Journal of Pharmaceutical Sciences and Nanotechnology. 11(1): 3937-3749.
http://www.ijpsnonline.com/Issues/3937_full.pdf
Reddy MS (2019). Genesis, Evaluation and Progression of A Breakthrough Discovery to Efficiently Cure Cancer Through Use of Dr. M.S. Reddy’s Multiple Mixed Strain Probiotics as Adjuvants Along with the Traditional Cancer Therapies, Through Restoration of Healthy and Balanced Intestinal Microbiota and their Microbiome. LOJ Phar & Cli Res 1(5): 107-109. LOJPCR.MS.ID.000121.
https://lupinepublishers.com/pharmacology-clinical-research-journal/pdf/LOJPCR.MS.ID.000121.pdf
Reddy MS (2020). Commonsense ways the dairy industry can address Coronavirus. Mar. 6. 2020, columns at http:// www.cheesemarketnews.com.
Reddy MS (2020). Latest Coronavirus episode of China - it's ramifications and applicable preventative and clinical treatment measures. AAPI (American Association of Physicians of Indian Origin) Journal. Mar. Issue-2020: In Print.
Reddy MS Reddy DRK (2015). A Preventative Medical Approach for Cancer Suppression. AAPI Journal. 06: 36-39
Reddy MS, and Reddy DRK (2011). Anti-aging: Review and Experimental Clinical Study of Bioavailable calcium - Probiotics and their effect on reversing osteopenia, osteoporosis, and other common health conditions. International journal of pharmaceutical sciences and Nanotechnology. Vol. 4. Issue 3. October December: 1436-1444.
https://pdfs.semanticscholar.org/493e/795de0505daa5815047112b85fd85bf299b2.pdf
Reddy MS, and Reddy DRK (2016). Development of multiple mixed strain Probiotics for "Probiotic therapy" under clinical conditions, to prevent or cure the deadly hospital acquired infections due to Clostridium difficile (C. diff) and Methicillin resistant staphylococcus aureus (MRSA). International Journal of Pharmaceutical Sciences and Nanotechnology. Sci. Nanotechnology: Vol 9. Issue 3. May-June: 3256-3281. http://www.ijpsnonline.com/Issues/3256_full.pdf
Reddy MS, and Reddy DRK (2016). Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Therapy. J Pharmaceutic and Nano technol. 4(3): 15-28. http://www.rroij.com/open-access/dr-ms-reddys-multiple-mixed-strain-probiotic-therapy-.pdf
Reddy MS, and Reddy DRK (2016). Isolation and determination of the major principle or causative agent behind the 2016 published breakthrough discovery of Dr. M.S. Reddy's "Multiple Mixed Strain Probiotic Therapy," in successfully treating the lethal hospital acquired infections due to Clostridium difficile (C. diff) and Methicillin resistant staphylococcus aureus (MRSA). International Journal of Pharmaceutical Science and Nanotechnology. Vol. 9. Issue 6. November/December: 3556-3566. http://www.ijpsnonline.com/Issues/3556_full.pdf
Reddy MS, and Reddy DRK (2017). An insight into the 2016 Best Medical award winning breakthrough microbial and Nanotechnology based discovery of Dr. M.S. Reddy’s Multiple Mixed Strain Probiotic Therapy, to successfully treat the nosocomial infections. Nano Technol and Nano Sci J. 1(1): 2-5. http://hendun.org/journals/NTNS/NTNS-102.php
Reddy MS, Reddy DRK, and Prasad NAV (2000). Herbal and pharmaceutical drugs enhanced with Probiotics. U.S. patent 6,080,401: 1-48.
https://patents.google.com/patent/US6080401A/en
Rung TC, Olson C, and Hsiao E (2017). Interactions between the Microbiota, immune and nervous systems in health and disease. Nature Neuroscience: 20(2). DOI: 10.1038/nn. 4476.
Schwiertz A, Taras D, Schafer K, Beijer S, Bos NA, Donus C, Hardt PD (2010). Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring). 18: 190-195. DOI: 10.1038/boy.2009.167.
Siven A, Corrales L, Hubert N, William JB, Aquino-Michaels K, and Early ZM (2015). Commercial bifidobacterium promotes anti-tumor immunity and facilitates anti-Pd-L1 efficiency. Science 350(6264): 1084-1089.
Turnbaugh PJ, and Gordon JI (2009). The core gut microbiome, energy balance and obesity. J Physiol. 587: 4153-4158. DOI: 10.1113/ physiology.2009.174136.
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, and Gordon JI (2006). An obesity associated gut microbiome with increased capacity for energy harvest. Nature. 444: 1027-1031. DOI: 10.1038/nature05414.
Wolf KJ, and Lorenz RG (2012). Gut Microbiota and obesity. Curr Obes Rep. DOI: 10.1007/S 12679 - 011 -0001 - 8.
Xu J and Gordon JI (2003). Honor thy symbionts. Proc Natl Acad Sci USA. Sep 2: 100(18): 10452-10459. DOI: 10.1073/pans. 1734063100.
Zhu B, Wang X, and Li L (2001). Human gut microbiome: The second genome of the human body. Protein Cell. DOI: 10.1007/S 1323-010-0093-Z.
