Recent Advances in Health Benefits of Moringa Oleifera
DOI:
https://doi.org/10.37285/ijpsn.2020.13.3.2Abstract
This article describes the recent research on the therapeutic potentials of Moringa oleifera, which is a rich source of phytochemicals. Since time immemorial, plants have been used for healing purposes. They are also the sources of numerous drugs. The reason for this is that all the plants possess a unique combination of phytochemicals in them. Moringa oleifera is a popular plant, which is extremely rich in nutrients and vital phytochemicals. This article provides information regarding its phytochemical content and the properties of those constituents. It also highlights the nutrient content and pharmacological activities of various classes of constituents present. The leaves have the most profound therapeutic effect. They have been shown to have, basically, hepatoprotective effect, antioxidant effect, neuroprotective and anti-tumour effect, and lowering of blood pressure. The roots have anti-inflammatory effect. The leaves and flowers also reflected anti-diabetic effect while the seeds have been shown to be effective against several cancer lines.
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Keywords:
Moringa oleifera, Constituents, Pharmacological properties
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Published
2020-05-31
How to Cite
1.
Gupta D, Soin D. Recent Advances in Health Benefits of Moringa Oleifera . Scopus Indexed [Internet]. 2020 May 31 [cited 2024 May 18];13(3):4870-5. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/927
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Review Articles
References
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Aekthammarat D, Pannangpetch P, Tangsucharit P (2019). Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats. Phytomedicine 54: 9-16.
Ali EN, and Chatterton CC (2018). Anticancer activity of Moringa oleifera leaves extract. AIP Conference Proceedings 2030: 020125.
Altemimi A, Lakhssassi N , Baharlouei A, Watson DG and David A. Lightfoot DA (2017). Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts. Plants 6(4): 42.
Antonini E, Lori R, Ninfali P & Scarpa E SA (2018). Combination of Moringin and Avenanthramide 2f Inhibits the Proliferation of Hep3B Liver Cancer Cells Inducing Intrinsic and Extrinsic Apoptosis. Nutrition and Cancer 70(7): 1159-1165.
Arise RO et al (2016), Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats. Acta Facultatis Medicae Naissensis. 33(4): 259-272.
Asmari AKA, Albalawi SM et al., (2015). Moringa oleifera as an Anti-Cancer Agent against Breast and Colorectal Cancer Cell Lines. Plos One 10(8): e0135814.
Barminas JT, Charles M, Emmanuel D (1998). Mineral composition of non-conventional leafy vegetables. Plant Foods Hum Nutr. 53(1): 29-36.
Berkovich L, Earon G, Ron I, Rimmon A, Vexler A, Lev-Ari S (2013). Moringa oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells BMC Complement. Altern. Med. 13: 212.
Bernstein, PS.; Li, B; Vachali, PP.; Gorusupudi, A; Shyam, R; Henriksen, BS.; Nolan, JM. (2015). Lutein, Zeaxanthin, and meso-Zeaxanthin: The Basic and Clinical Science Underlying Carotenoid-based Nutritional Interventions against Ocular Disease. Progress in Retinal and Eye Research. 50: 34-66.
Charlene M, Luke C, Paul S, Ewa C, Edwin M (2016). Comparative analyses of flavonoid content in Moringa oleifera and Moringa ovalifolia with the aid of UHPLC-qTOF-MS fingerprinting. South African Journal of Botany, 105: 116-122.
Coppin JP, Xu Y et al., (2013). Determination of flavonoids by LC/MS and anti-inflammatory activity in Moringa oleifera. Journal of Functional Foods. 5(4): 1892-1899.
Cui C, Chen S, Wang X et al., (2019). Characterization of Moringa oleifera roots polysaccharide MRP-1 with anti-inflammatory effect. International Journal of Biological Macromolecules. 132: 844-851.
Cushnie TP, Lamb AJ (2011). Recent advances in understanding the antibacterial properties of flavonoids. International Journal of Antimicrobial Agents. 38 (2): 99-107.
Ekong MB ,. Ekpo MM, Akpanyung EO, Nwaokonko DU (2017). Neuroprotective effect of Moringa oleifera leaf extract on aluminium-induced temporal cortical degeneration. Metabolic Brain Disease 32(5): 1437-1447.
El-Gharabawy RM et al (2019). Ameliorating Effect of Moringa against Liver and Kidney Injury Induced by Monosodium Glutamate. Annual Research & Review in Biology. 33(3): 1-10.
Foidl N, Makkar HPS, Becker K (2001). The potential use of Moringa oleifera for agriculture and industrial uses. Dar Es Salaam October 20 - November 2 2001: 1-20
Fuglie L J (2001). The Moringa Tree: A local solution to malnutrition Church World Service in Senegal October 29 - November 2 2001, Dar es Salaam.
Gopalakrishnan L, Doriya K, and Santhosh KD (2016). Moringa oleifera: A review on nutritive importance and its medicinal application. Food Sci and Human Wellness 5(2): 49-56.
Jahan A, Hossain MH, Ahmed KS et al., (2018). Antioxidant activity of Moringa oleifera seed extracts. Oriental Pharmacy and Experimental Medicine, 18(4): 299-307.
Jan AT et al., (2010). Dietary Flavonoid Quercetin and Associated Health Benefits–An Overview. Food Reviews International. 26(3): 302-317.
Liao P, Lai M et al., (2018) Identification of β-Sitosterol as in Vitro Anti-Inflammatory Constituent in Moringa oleifera. J. Agric. Food Chem. 66(41): 10748-10759.
Marrelli M, Conforti F, Araniti F, and Statti GA (2016). Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity. Molecules. 21(10): 1404.
Oduro I, Ellis W O, Owusu D. (2008). Nutritional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves. Sci. Res. Essays, 3(2): 57-60.
Ogbunugafor HA et al.,, (2011). Physico-chemical and Antioxidant Properties of Moringa oleifera Seed Oil. Pakistan Journal of Nutrition 10 (5): 409-414.
Paikra BK, Dhongade HKJ and Gidwani B (2017). Phytochemistry and Pharmacology of Moringa oleifera Lam. J Pharmaco-puncture. 20(3): 194-200.
Radovich T (2011). CR Elevitch (ed.). Farm and Forestry Production and Marketing Profile for Moringa (revised February 2011) Specialty Crops for Pacific Island Agroforestry.
Saini, RK & Shetty N and Parvatam G (2014). Carotenoid content in vegetative and reproductive parts of commercially grown Moringa oleifera Lam. cultivars from India by LC–APCI–MS. European Food Research and Technology 238(6): 971-978.
Shu X, Wang D et al (2018). Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1. Journal of Functional Foods 50: 93-103.
Stauth D (2007). Studies force new view on biology of flavonoids. EurekAlert!, Adapted from a news release issued by Oregon State University
Sun C, Li W et al., (2019). In vitro/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury. Food and Chemical Toxicology 131: 110531.
Taylor P W, Hamilton-Miller JM, and Stapleton PD (2005). Antimicrobial properties of green tea catechins. Food Science and Technology Bulletin. 2(7): 71-81.
Thurber MD and Fahey JW (2010). Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the diffusion of innovations theory. Ecol. Food Sci. Nutr. 48(3): 212- 225.
Uphadek B, Shinkar DM, Patil PB and Saudagar RB (2018). Moringa oleifera as a pharmaceutical excipient. International Journal of Current Pharmaceutical Research 10(2): 13-16.
Vongsak et al., (2013). Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method. Industrial Crops and Products 44: 566-571.
Zeng K, Ying Li, Yang W, and Ge Y (2019). Moringa oleifera seed extract protects against brain damage in both the acute and delayed stages of ischemic stroke. Experimental Gerontology. 122: 99-108.
Aekthammarat D, Pannangpetch P, Tangsucharit P (2019). Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats. Phytomedicine 54: 9-16.
Ali EN, and Chatterton CC (2018). Anticancer activity of Moringa oleifera leaves extract. AIP Conference Proceedings 2030: 020125.
Altemimi A, Lakhssassi N , Baharlouei A, Watson DG and David A. Lightfoot DA (2017). Phytochemicals: Extraction, Isolation, and Identification of Bioactive Compounds from Plant Extracts. Plants 6(4): 42.
Antonini E, Lori R, Ninfali P & Scarpa E SA (2018). Combination of Moringin and Avenanthramide 2f Inhibits the Proliferation of Hep3B Liver Cancer Cells Inducing Intrinsic and Extrinsic Apoptosis. Nutrition and Cancer 70(7): 1159-1165.
Arise RO et al (2016), Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats. Acta Facultatis Medicae Naissensis. 33(4): 259-272.
Asmari AKA, Albalawi SM et al., (2015). Moringa oleifera as an Anti-Cancer Agent against Breast and Colorectal Cancer Cell Lines. Plos One 10(8): e0135814.
Barminas JT, Charles M, Emmanuel D (1998). Mineral composition of non-conventional leafy vegetables. Plant Foods Hum Nutr. 53(1): 29-36.
Berkovich L, Earon G, Ron I, Rimmon A, Vexler A, Lev-Ari S (2013). Moringa oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells BMC Complement. Altern. Med. 13: 212.
Bernstein, PS.; Li, B; Vachali, PP.; Gorusupudi, A; Shyam, R; Henriksen, BS.; Nolan, JM. (2015). Lutein, Zeaxanthin, and meso-Zeaxanthin: The Basic and Clinical Science Underlying Carotenoid-based Nutritional Interventions against Ocular Disease. Progress in Retinal and Eye Research. 50: 34-66.
Charlene M, Luke C, Paul S, Ewa C, Edwin M (2016). Comparative analyses of flavonoid content in Moringa oleifera and Moringa ovalifolia with the aid of UHPLC-qTOF-MS fingerprinting. South African Journal of Botany, 105: 116-122.
Coppin JP, Xu Y et al., (2013). Determination of flavonoids by LC/MS and anti-inflammatory activity in Moringa oleifera. Journal of Functional Foods. 5(4): 1892-1899.
Cui C, Chen S, Wang X et al., (2019). Characterization of Moringa oleifera roots polysaccharide MRP-1 with anti-inflammatory effect. International Journal of Biological Macromolecules. 132: 844-851.
Cushnie TP, Lamb AJ (2011). Recent advances in understanding the antibacterial properties of flavonoids. International Journal of Antimicrobial Agents. 38 (2): 99-107.
Ekong MB ,. Ekpo MM, Akpanyung EO, Nwaokonko DU (2017). Neuroprotective effect of Moringa oleifera leaf extract on aluminium-induced temporal cortical degeneration. Metabolic Brain Disease 32(5): 1437-1447.
El-Gharabawy RM et al (2019). Ameliorating Effect of Moringa against Liver and Kidney Injury Induced by Monosodium Glutamate. Annual Research & Review in Biology. 33(3): 1-10.
Foidl N, Makkar HPS, Becker K (2001). The potential use of Moringa oleifera for agriculture and industrial uses. Dar Es Salaam October 20 - November 2 2001: 1-20
Fuglie L J (2001). The Moringa Tree: A local solution to malnutrition Church World Service in Senegal October 29 - November 2 2001, Dar es Salaam.
Gopalakrishnan L, Doriya K, and Santhosh KD (2016). Moringa oleifera: A review on nutritive importance and its medicinal application. Food Sci and Human Wellness 5(2): 49-56.
Jahan A, Hossain MH, Ahmed KS et al., (2018). Antioxidant activity of Moringa oleifera seed extracts. Oriental Pharmacy and Experimental Medicine, 18(4): 299-307.
Jan AT et al., (2010). Dietary Flavonoid Quercetin and Associated Health Benefits–An Overview. Food Reviews International. 26(3): 302-317.
Liao P, Lai M et al., (2018) Identification of β-Sitosterol as in Vitro Anti-Inflammatory Constituent in Moringa oleifera. J. Agric. Food Chem. 66(41): 10748-10759.
Marrelli M, Conforti F, Araniti F, and Statti GA (2016). Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity. Molecules. 21(10): 1404.
Oduro I, Ellis W O, Owusu D. (2008). Nutritional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves. Sci. Res. Essays, 3(2): 57-60.
Ogbunugafor HA et al.,, (2011). Physico-chemical and Antioxidant Properties of Moringa oleifera Seed Oil. Pakistan Journal of Nutrition 10 (5): 409-414.
Paikra BK, Dhongade HKJ and Gidwani B (2017). Phytochemistry and Pharmacology of Moringa oleifera Lam. J Pharmaco-puncture. 20(3): 194-200.
Radovich T (2011). CR Elevitch (ed.). Farm and Forestry Production and Marketing Profile for Moringa (revised February 2011) Specialty Crops for Pacific Island Agroforestry.
Saini, RK & Shetty N and Parvatam G (2014). Carotenoid content in vegetative and reproductive parts of commercially grown Moringa oleifera Lam. cultivars from India by LC–APCI–MS. European Food Research and Technology 238(6): 971-978.
Shu X, Wang D et al (2018). Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1. Journal of Functional Foods 50: 93-103.
Stauth D (2007). Studies force new view on biology of flavonoids. EurekAlert!, Adapted from a news release issued by Oregon State University
Sun C, Li W et al., (2019). In vitro/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury. Food and Chemical Toxicology 131: 110531.
Taylor P W, Hamilton-Miller JM, and Stapleton PD (2005). Antimicrobial properties of green tea catechins. Food Science and Technology Bulletin. 2(7): 71-81.
Thurber MD and Fahey JW (2010). Adoption of Moringa oleifera to combat under-nutrition viewed through the lens of the diffusion of innovations theory. Ecol. Food Sci. Nutr. 48(3): 212- 225.
Uphadek B, Shinkar DM, Patil PB and Saudagar RB (2018). Moringa oleifera as a pharmaceutical excipient. International Journal of Current Pharmaceutical Research 10(2): 13-16.
Vongsak et al., (2013). Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method. Industrial Crops and Products 44: 566-571.
Zeng K, Ying Li, Yang W, and Ge Y (2019). Moringa oleifera seed extract protects against brain damage in both the acute and delayed stages of ischemic stroke. Experimental Gerontology. 122: 99-108.
