Development and Evaluation of Chia Seed Mucilage-based Buccal Mucoadhesive, Sustained Release Tablet of Venlafaxine

DOI:

https://doi.org/10.37285/ijpsn.2016.9.6.4

Authors

  • Pankaj P Nerkar
  • Hitendra Mahajan
  • Pradum Ige
  • Rima Solanki

Abstract

In the present study we performed extraction of chia seed mucilage, formulation, and evaluation of buccal mucoadhesive tablet containing extracted mucialge and venlafaxine, an commonly used antidepressant. Tablets were prepared using a formulation mixture of calcium phosphate, talc and magnesium stearate. Tablets were prepared by experimental factorial design software, using central composite design; where the concentration of chia seeds mucilage and that of magnesium stearates were independent variables. Drug release, friability and mucoadhesive strength were studied as dependent variables. Tablets were characterized for post compression profile. The optimized formulation showed the maximum drug release as 99.4% in 6 h, friability of 0.53% and mucoadhesive strength of 20.3 g. These features appear to be adequate for developing a buccal mucoadhesive drug delivery system for venlafaxine.

 

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Keywords:

Mucilage, venlafaxine, buccal tablets, sustained release, drug release, mucoadhesion, Chia seed mucilage

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Published

2016-11-30

How to Cite

1.
Nerkar PP, Mahajan H, Ige P, Solanki R. Development and Evaluation of Chia Seed Mucilage-based Buccal Mucoadhesive, Sustained Release Tablet of Venlafaxine. Scopus Indexed [Internet]. 2016 Nov. 30 [cited 2024 Dec. 11];9(6):3536-43. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/891

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Section

Research Articles

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