Formulation and Evaluation of Salbutamol Sulphate Sublingual Films
DOI:
https://doi.org/10.37285/ijpsn.2017.10.5.4Abstract
Salbutamol is a short-acting, selective beta-2-adrenergic receptor agonist used in treatment of asthma and COPD. In the present work, sublingual films of Salbutamol sulphate were developed with a view to enhance the patient compliance and provide quick onset of action. Salbutamol has a bioavailability of 53 - 60%. The goal of the study was to formulate sublingual films of Salbutamol sulphate to achieve a better dissolution rate and further improving the bioavailability of the drug. Sublingual films prepared by solvent casting method using film forming polymers HPMC-E5, HPMC-E15 and Maltodextrin in different ratios. The prepared batches of films were evaluated for the drug content, weight variation, film thickness, disintegration time and in vitro dissolution studies. Among all, the formulation B1 containing HPMC-E15 with a drug: polymer ratio (1:6) was found to be the best formulation which showed 98.36% of the drug release within 15 minutes and disintegration time 18 sec. This study shows the viability of developing sublingual films of salbutamol.
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Keywords:
Sublingual Films, Salbutamol Sulphate, HPMC, Maltodextrin
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Published
2017-09-30
How to Cite
1.
Kumar YS, B D, M M. Formulation and Evaluation of Salbutamol Sulphate Sublingual Films. Scopus Indexed [Internet]. 2017 Sep. 30 [cited 2024 May 17];10(5):3836-43. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/862
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Research Articles
References
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Patel, V. F., Liu, F., and Brown, M. B. (2012). Modeling the oral cavity: In vitro and in vivo evaluations of buccal drug delivery systems. Journal of Controlled Release, 161(3): 746-756.
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Prabhu, P., Malli, R., Koland, M., Vijaynarayana, K., D’Souza, U., Harish, N., and Charyulu, R. (2011). Formulation and evaluation of fast dissolving films of levocitirizine di hydrochloride. International Journal of Pharmaceutical Investigation, 1(2): 99-104.
Rahimzadeh, A., and Eslamian, M. (2017). Stability of thin liquid films subjected to ultrasonic vibration and characteristics of the resulting thin solid films. Chemical Engineering Science, 158: 587-598.
Semalty, M., Semalty, A., and Kumar, G. (2008). Formulation and characterization of mucoadhesive buccal films of glipizide. Indian Journal of Pharmaceutical Sciences, 70(1): 43-8.
Stempel, D. A., Yeakey, A. M., and Pascoe, S. J. (2016). Safety Study of Salmeterol in Asthma in Adults. New England Journal of Medicine, 375(11): 1096-1098.
Takeuchi, Y., Usui, R., Ikezaki, H., Tahara, K., and Takeuchi, H. (2017). Characterization of orally disintegrating films: A feasibility study using an electronic taste sensor and a flow-through cell. Journal of Drug Delivery Science and Technology, 39: 104-112.
Briggs, A. H., Bousquet, J., Wallace, M. V., Busse, W. W., Clark, T. J. H., Pedersen, S. E., GOAL Investigators Group. (2006). Cost-effectiveness of asthma control: an economic appraisal of the GOAL study. Allergy, 61(5): 531-536.
Chaturvedi, A., Srivastava, P., Yadav, S., Bansal, M., Garg, G., and Sharma, P. K. (2011). Fast dissolving films: a review. Current Drug Delivery, 8(4): 373-80.
Chaudhary, H., Gauri, S., Rathee, P., and Kumar, V. (2013). Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design. Bulletin of Faculty of Pharmacy, Cairo University, 51(2): 193-201.
Dixit, R. P., and Puthli, S. P. (2009). Oral strip technology: Overview and future potential. Journal of Controlled Release, 139(2): 94-107.
Felton, L. A. (2006). A Review of: “Handbook of Pharmaceutical Excipients, 5th edition.” Drug Development and Industrial Pharmacy, 32(8): 1003-1003.
Fusco, S., Cariati, D., Schepisi, R., Ganzetti, R., and Sestili, M. (2016). Management of oral drug therapy in elderly patients with dysphagia. Journal of Gerontology and Geriatrics, 64: 9-20.
Joshi, P., Patel, H., Patel, V., and Panchal, R. (2012). Formulation development and evaluation of mouth dissolving film of domperidone. Journal of Pharmacy & Bioallied Sciences. 4(5) Suppl 1: S108-S109.
Kathpalia, H., and Gupte, A. (2013). An introduction to fast dissolving oral thin film drug delivery systems: a review. Current Drug Delivery, 10(6): 667-84.
Koland, M., Vijayanarayana, K., Charyulu, Rn., and Prabhu, P. (2011). In vitro and in vivo evaluation of chitosan buccal films of ondansetron hydrochloride. International Journal of Pharmaceutical Investigation, 1(3): 164.
Kumar, S., and Gupta, S. K. (n.d.). Rosin: a naturally derived excipient in drug delivery systems. Polimery W Medycynie, 43(1): 45-8.
Mašek, J., Lubasová, D., Lukáč, R., Turánek-Knotigová, P., Kulich, P., Plocková, J., and Turánek, J. (2017). Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles - important step towards effective mucosal vaccines. Journal of Controlled Release, 249, 183-195.
Mehta, D. M., Dave, D. J., Dadhaniya, D. V., Shelat, P. K., Parejiya, P. B., and Barot, B. S. (2014). Application of Box-Behnken design to formulate and optimize multipolymeric fast dissolving film of rizatriptan benzoate. Asian Journal of Pharmaceutics (AJP): Free Full Text Articles from Asian J Pharm, 8(1).
Morell, P., Hernando, I., and Fiszman, S. M. (2014). Understanding the relevance of in-mouth food processing. A review of in vitro techniques. Trends in Food Science & Technology, 35(1): 18-31.
Newton, A. M. J., and Lakshmanan, P. (2014). Effect of HPMC - E15 LV premium polymer on release profile and compression characteristics of chitosan/ pectin colon targeted mesalamine matrix tablets and in vitro study on effect of pH impact on the drug release profile. Recent Patents on Drug Delivery & Formulation, 8(1): 46-62.
Parikh, A., Agarwal, S., and Raut, K. (n.d.). A Review on Applications of Maltodextrin in Pharmaceutical Industry. International Journal of Pharmacy and Biological Sciences, 2230-7605.
Parkash, V., Maan, S., Deepika, Yadav, S. K., Hemlata, and Jogpal, V. (2011). Fast disintegrating tablets: Opportunity in drug delivery system. Journal of Advanced Pharmaceutical Technology & Research, 2(4): 223-35.
Patel, V. F., Liu, F., and Brown, M. B. (2012). Modeling the oral cavity: In vitro and in vivo evaluations of buccal drug delivery systems. Journal of Controlled Release, 161(3): 746-756.
Parkash, V., Maan, S., Deepika, Yadav, S. K., Hemlata, and Jogpal, V. (2011). Fast disintegrating tablets: Opportunity in drug delivery system. Journal of Advanced Pharmaceutical Technology & Research, 2(4): 223-35.
Prabhu, P., Malli, R., Koland, M., Vijaynarayana, K., D’Souza, U., Harish, N., and Charyulu, R. (2011). Formulation and evaluation of fast dissolving films of levocitirizine di hydrochloride. International Journal of Pharmaceutical Investigation, 1(2): 99-104.
Rahimzadeh, A., and Eslamian, M. (2017). Stability of thin liquid films subjected to ultrasonic vibration and characteristics of the resulting thin solid films. Chemical Engineering Science, 158: 587-598.
Semalty, M., Semalty, A., and Kumar, G. (2008). Formulation and characterization of mucoadhesive buccal films of glipizide. Indian Journal of Pharmaceutical Sciences, 70(1): 43-8.
Stempel, D. A., Yeakey, A. M., and Pascoe, S. J. (2016). Safety Study of Salmeterol in Asthma in Adults. New England Journal of Medicine, 375(11): 1096-1098.
Takeuchi, Y., Usui, R., Ikezaki, H., Tahara, K., and Takeuchi, H. (2017). Characterization of orally disintegrating films: A feasibility study using an electronic taste sensor and a flow-through cell. Journal of Drug Delivery Science and Technology, 39: 104-112.
