Functionalized Nano-graphene Oxide as Multi-modal Clinic for Effective Drug Delivery

DOI:

https://doi.org/10.37285/ijpsn.2017.10.4.3

Authors

  • Soumitra Satapathi
  • Rutusmita Mishra
  • Manisha Chatterjee
  • Partha Roy
  • Somesh Mohapatra

Abstract

Nano-materials based drug delivery modalities to specific organs and tissues has become one of the critical endeavors in pharmaceutical research. Recently, two-dimensional graphene has elicited considerable research interest because of its potential application in drug delivery systems. Here we report, the drug delivery applications of PEGylated nano-graphene oxide (nGO-PEG), complexed with a multiphoton active and anti-cancerous diarylheptanoid drug curcumin. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug curcumin due to its high surface area and easy surface functionalization. nGO was synthesized by modified Hummer’s method and confirmed by XRD analysis. The formation of nGO, nGO-PEG and nGO-PEG-Curcumin complex were monitored through UV-vis, IR spectroscopy. MTT assay and AO/EB staining found that nGO-PEG-Curcumin complex afforded highly potent cancer cell killing in vitro with a human breast cancer cell line MCF7.

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Keywords:

Pharmacology, Drug Delivery, Nano-Graphene, Cancer, Controlled Release

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Published

2017-07-31

How to Cite

1.
Satapathi S, Mishra R, Chatterjee M, Roy P, Mohapatra S. Functionalized Nano-graphene Oxide as Multi-modal Clinic for Effective Drug Delivery. Scopus Indexed [Internet]. 2017 Jul. 31 [cited 2024 Dec. 11];10(4):3768-71. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/853

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Section

Research Articles

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