Mechanistic Evaluation of Antinociceptive Effects of Bioactive Guided Fractions of Barleria prionitis

DOI:

https://doi.org/10.37285/ijpsn.2017.10.3.3

Authors

  • Venkatesh Sama
  • Azmathunnisa Begum
  • Rajesh Bolleddu
  • Ravi Alvala
  • Jaya Prakash D

Abstract

Barleria prionitis Linn.(Acanthaceae) is a prickly shrub and traditionally whole plant is used as anti-inflammatory, expectorant, analgesic, diuretic, antirheumaticand antidiabetic. This study was conducted to investigate the antinociceptive and CNS depressant activity of ethanolic extract and the fractions of B. prionitis in mice. Ethanol extract and its fractions were tested at a dose of 200 and 400 mg/kg. Ethanol, petroleum ether and chloroform fractions demonstrated significant antinociceptive activity at 400 mg/kg and significantly increased the latency in hot plate test and the action was antagonised by naloxone, indicating a potential opioid-like mechanism. In conclusion, the ethanol, pet ether and chloroform fractions of B. prionitis markedly demonstrated the antinociceptive action. The CNS depressant and good protective effect on pain stimuli suggest that the possible mechanisms appear to be due to involvement of opioid and/or peripheral receptors. 

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Keywords:

Antinociceptive activity, analgesia, morphine, naloxone, Barleria prionitis

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Published

2017-05-31

How to Cite

1.
Sama V, Begum A, Bolleddu R, Alvala R, D JP. Mechanistic Evaluation of Antinociceptive Effects of Bioactive Guided Fractions of Barleria prionitis. Scopus Indexed [Internet]. 2017 May 31 [cited 2024 Dec. 11];10(3):3715-27. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/841

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Research Articles

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