Solubility Enhancement Techniques for Poorly Water-Soluble Drugs

DOI:

https://doi.org/10.37285/ijpsn.2017.10.3.1

Authors

  • Amol S Deshmukh
  • Kundan J Tiwari
  • Vijay R Mahajan

Abstract

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for optimum pharmacological response. Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Poor aqueous solubility is a major problem encountered with formulation development of new chemical entities. There are over 40% of new chemical entities that exhibit poor solubility and low bioavailability. As per BCS classification system, these drugs comes under BCS class II that show poor solubility and high permeability. The bioavailability of these drugs can be dramatically improved by increasing the solubility of these drugs. This review article highlights a number of techniques for enhanc

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Keywords:

Solubility, BCS class II drugs, solubility enhancement, bioavailability

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Published

2017-05-31

How to Cite

1.
Deshmukh AS, Tiwari KJ, Mahajan VR. Solubility Enhancement Techniques for Poorly Water-Soluble Drugs. Scopus Indexed [Internet]. 2017 May 31 [cited 2024 Dec. 11];10(3):3701-8. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/839

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Section

Review Articles

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