Synthesis, Characterization and Antimicrobial Activity of 4-Substituted-Benzylpiperazinyl Methanone Derivatives

DOI:

https://doi.org/10.37285/ijpsn.2017.10.2.7

Authors

  • Mahesh Chidara
  • Satla Shobha Rani

Abstract

Novel antibacterial compounds are needed to combat the emerging bacterial infections. In this study, synthesis of 4-substituted benzylpiperazin-1-yl methanone derivatives was carried out by 4-substituted benzyl chloride (I) with piperazine in presence of ethanol to obtain 4-substituted benzylpiperazines (II). Benzylpiperazines (II) was condensed with different substituted esters in presence of diluted acid to produce title compounds (IIIa–e, IVa-e and Va-e). All the title compounds were screened for possible antibacterial activity against P. Vulgaris, S. Aureas, E. Coli, B. Subtillus and antifungal activity against Altenaria, Culvalaria, C. Albicans and A. Niger. Among the compounds synthesized IVb, IVd and IVf demonstrated good antibacterial activity; IVb, IVc, and IVe showed good antifungal activity. The activities of the synthesized compounds are compared with the standard and other test compounds. The structures of synthesized compounds were established by elemental analysis, IR, H NMR and Mass spectral data. Future studies will confirm their efficacy and utility as antibacterial agents. 

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Keywords:

Benzylpiperazine, antimicrobial activity, antibacterial, antifungal, infections

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Published

2017-03-31

How to Cite

1.
Chidara M, Rani SS. Synthesis, Characterization and Antimicrobial Activity of 4-Substituted-Benzylpiperazinyl Methanone Derivatives. Scopus Indexed [Internet]. 2017 Mar. 31 [cited 2024 Jun. 20];10(2):3684-7. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/837

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Section

Research Articles

References

Bakhtmah P (2011). Synthesis, photochemical probe and antimicrobial effects of novel Norflaxacin analogues. International Journal of Chemistry Research 2(3): 342-348.
Barry P (1986). A Procedure for testing antimicrobial agents in agar media: theoretical considerations. Antibiotics in Laboratory Medicine 2: 1-26.
Hussein MA (2005). Synthesis of some new 1,4-Disubstituted piperazine-2,3-dione derivatives of potential anthelmintic . Bull. Pharm. Sci., 28(1): 37-44.
Immadi S (2010). Anticancer and antimicrobial activity of1-[(5-sustituted-1,3,4-oxadiazol-2-yl)methyl]-4-benzylpiperazines. International Journal of Phytopharmacology; 1(2): 133-136.
Kharb R, Bansal K and Sharma AK (2012). A valuable insight into recent advances on antimicrobial activity of piperazine derivatives. Scholars Research Library Der Pharma Chemica 4(6): 2470-2488.
Liu MC, Lin TS and Sartorelli AC (1995). Chemical and biological properties of cytotoxic a-N-Heterocyclic carboxaldehyde thio-semicarbazones. Prog Med Chem; 32: 1-35.
Rollas S, Ku¨c and u¨kgu¨zel SG (2007). Biological activities of hydrazone derivatives. Molecules; 12(8): 1910-1939.
Thakran K (2012). Synthesis and pharmacological evaluation of 1-Benzhydril piperazine derivatives. International Journal of Pharmaceutical Sciences and Research 3(1): 213-217.