Synthesis, Characterization and Antimicrobial Activity of 4-Substituted-Benzylpiperazinyl Methanone Derivatives



  • Mahesh Chidara
  • Satla Shobha Rani


Novel antibacterial compounds are needed to combat the emerging bacterial infections. In this study, synthesis of 4-substituted benzylpiperazin-1-yl methanone derivatives was carried out by 4-substituted benzyl chloride (I) with piperazine in presence of ethanol to obtain 4-substituted benzylpiperazines (II). Benzylpiperazines (II) was condensed with different substituted esters in presence of diluted acid to produce title compounds (IIIa–e, IVa-e and Va-e). All the title compounds were screened for possible antibacterial activity against P. Vulgaris, S. Aureas, E. Coli, B. Subtillus and antifungal activity against Altenaria, Culvalaria, C. Albicans and A. Niger. Among the compounds synthesized IVb, IVd and IVf demonstrated good antibacterial activity; IVb, IVc, and IVe showed good antifungal activity. The activities of the synthesized compounds are compared with the standard and other test compounds. The structures of synthesized compounds were established by elemental analysis, IR, H NMR and Mass spectral data. Future studies will confirm their efficacy and utility as antibacterial agents. 


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Benzylpiperazine, antimicrobial activity, antibacterial, antifungal, infections




How to Cite

Chidara M, Rani SS. Synthesis, Characterization and Antimicrobial Activity of 4-Substituted-Benzylpiperazinyl Methanone Derivatives. Scopus Indexed [Internet]. 2017 Mar. 31 [cited 2024 Jun. 20];10(2):3684-7. Available from:



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