Self Microemulsifying Nutraceutical and Drug Delivery Systems

DOI:

https://doi.org/10.37285/ijpsn.2014.7.3.3

Authors

  • Vikrant P Wankhade
  • Nivedita S Kale
  • K.K Tapar

Abstract

Many chemical entities and nutraceuticals are poor water soluble and show high lipophilicity. It’s difficult to formulate them into oral formulation because of its low aqueous solubility which ultimately affects bioavailability. To enhance the bioavailability of such drugs compounds, self microemulsifying drug delivery system is the reliable drug delivery system. In this system the drug is incorporated in the isotropic system and formulated as unit dosage form. Self microemulsifying drug delivery system is the novel emulsified system composed of anhydrous isotropic mixture of oils, surfactant, and co solvent and sometimes co surfactant. Drug is directly dispersed into the entire gastro intestinal tract with continuous peristaltic movement and drug is available in the solution form of microemulsion, absorbed through lymphatic system and bypasses the dissolution step. Hence they increase the patient compliance. The excipients are selected on basis of construction of ternary phase diagram. Self micro-emulsifying drug delivery system is very useful for drug in which drug dissolution is rate limiting step. This review describes the novel approaches and evaluation parameters of the self microemulsifying drug delivery system towards different classic drugs, proteins-peptides, and nutraceuticals in various oral microemulsion compositions and microstructures.

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Keywords:

Nutraceuticals, Microstructure, Microemulsion, Ternary phase-diagram, Bioavailability

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Published

2014-08-31

How to Cite

1.
Wankhade VP, Kale NS, Tapar K. Self Microemulsifying Nutraceutical and Drug Delivery Systems. Scopus Indexed [Internet]. 2014 Aug. 31 [cited 2024 Oct. 13];7(3):2520-8. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/721

Issue

Section

Review Articles

References

Abdalla A, Klein S, Mader K (2008). A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: Characterization, dissolution, in vitro digestion and incorporation into solid pellets. Eur J Pharm Sci 35: 457-464.

Ajazuddin, Alexander A, Khichariya A, Gupta S, Patel RJ Giri TK, Tripathi DK(2013). Recent expansions in an emergent novel drug delivery technology. Emulgel J Controlled Rel 28(171):122-32.

Amrit Paudel, Zelam Ayenew worku et al., (2013). Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations. Int J Pharmaceutics 453: 253-284.

Bega S, Jenaa SS, Patraa NC, Mohammad R, Swaina S, Sruti J, Raoa MB, Singh B (2013). Development of solid self-nanoemulsifying granules (SSNEGs) of ondansetron hydrochloride with enhanced bioavailability potential. Colloids and Surfaces B: Biointerfaces101: 414-423.

Buckley ST, Frank KJ, Fricker Fb, Brandl M (2013). Biopharmaceutical classification of poorly soluble drugs with respect to enabling formulations. European Journal of Pharmaceutical Sciences 50(1-2): 8-16.

Carrier RL, Buyukozturk F, Benneyan JC (2010). Impact of emulsion-based drug delivery system on intestinal permeability and drug release kinetics. J Controlled Rel 142:22-29.

Chauhan B, Kumar G, Kalam N, Ansari S.H (2013). Current concepts and prospects of herbal nutraceutical: A review. J Adv Pharma Tech Res 4:1-13.

Chongprakobkita S, Maniratanachoteb R, Tachaboonyakiatc W (2013). Oil-in-water emulsions stabilized by sodium phosphorylated chitosan. Carbohydrate Polymers 96: 82-90.

Das R, Agrawal YK (2011). Raman spectroscopy: Recent advancements, techniques and applications. Vibrational Spectroscopy 57: 163-176.

Devraja R, Williamsb HD, Warrena DB, Mullertzc A, PorterbCJ, Poutona CW (2013). In vitro digestion testing of lipid-based delivery systems: Calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilisation capacity of colloidal digestion products. International Journal of Pharmaceutics 441: 323-333.

Elsheikh M, Elnaggar Y, Gohar E, Abdallah O (2012). Nanoemulsion liquid preconcentrates for raloxifene hydrochloride: optimization and in vivo appraisal. Int J Nanomedicine 7: 3787-3802.

Estrada C, Francisco J. Guti E, Albillosb SM, Sanzc C, Cruz Z,GuerraA, ReverterJ, ArezM, GatonP,FerreroC,Olabarrieta I, OlasagastiM,RainieriS,Patino D, RojoR, HualdeA, AbajoM, Mussons M (2013). Methods for the nanoencapsulation of β-carotene in the food sector. Food Science and Technology 32: 72-83.

Faisal W, Ruane-OHorab T M, O’Driscoll C, Griffin BT (2013). A novel lipid-based solid dispersion for enhancing oral bioavailability of Lycopene – In vivo evaluation using a pig model. International Journal of Pharmaceutics 453: 307-314.

Fei Y, Edmund S. Kostewicz, Ming-ThauSheu, Jennifer B (2013). Analysis of the enhanced oral bioavailability of fenofibrate lipid formulations in fasted humans using an in vitro–in silico–in vivo approach. European Journal of Pharmaceutics and Biopharmaceutics 3: 001.

Fouada SA, Basaliousb EB, El-Nabarawib MA, Tayel SA (2013). Micro emulsion and poloxamer micro emulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: In vitro/in vivo evaluation. International Journal of Pharmaceutics 453: 569-578.

Hea W, Lua Y, Qia J, Chenc L, Hud F, Wua W(2013). Food proteins as novel nanosuspension stabilizers for poorly water-soluble drugs. International Journal of Pharmaceutics 441: 269-278.

Huanga Y, Tianb R, Huc W, JiaYd, Zhanga J, Jianga H, Zhanga L (2013). A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS. Carbohydrate Polymers 92: 2218-2223.

Huiling M, Rene H, Mullertza AB (2013). Lipid-based formulations for oral administration of poorly water-soluble drugs. International Journal of Pharmaceutics 453: 215-224.

Jain S, Jain AK, Pohekar M, Thanki K (2013). Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: Implications for drug-induced cardiotoxicity and nephrotoxicity. Free Radical Biology and Medicine 65:117-130.

Joshi RP, Negi G, Kumar A, Pawar Y, Munjal B, Bansal A, Sharma SS (2013). SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: An insight into its mechanism of neuroprotection. Nanomedicine: Nanotechnology, Biology, and Medicine 9:776-785.

Kallakunta VR, Bandari S, Jukanti R (2012). Oral self-emulsifying powder of lercanidipine hydrochloride: Formulation and evaluation. Powder Technology 221: 375-382.

Keena JM, James W. Ginitya MC, Williams RO (2013). Enhancing bioavailability through thermal processing. International Journal of Pharmaceutics 450: 185-196.

Khamkar G. S (2011). Self-micro-emulsifying drug delivery system (smedds) o/w micro emulsion for BCS class II drugs: an approach to enhance an oral bioavailability. International journal of pharmacy and sciences, pharmaceutical 3:3.

KohliK, ChopraS, DharD, AroraS, Khar R.K (2010). Self emulsifying drug delivery system: an approach to enhance oral bioavailability. Drug discovery today 15: 21-22.

Lam RS, Nickerson MT (2013). Food proteins: A review on their emulsifying properties using a structure-function approach. Food Chemistry 141: 975-984.

Li J, Liu P, Liu JP, Yang JK, Zhang WL, Fan FQ, Kan SL, Cui Y, Zhang WJ (2013). Bioavailability and foam cells permeability enhancement of Salvianolic acid B pellets based on drug-phospholipids complex technique. European Journal of Pharmaceutics and Bio pharmaceutics 83: 76-86.

Mandawgadea S, Sharma S, Pathak S, Patravale VB (2008). Development of SMEDDS using natural lipophile: Application to Artemether delivery. Int J Pharmaceutics 362: 179-183.

McConville C, Friend D (2013). Development and characterization of aself-micro emulsifying drug delivery systems (SMEDDSs) for the vaginal administration of the antiretroviral UC-781. European Journal of Pharmaceutics and Biopharmaceutics 83: 322-329.

Mekjaruskula C, Yang YT, Leedb MGD, Sadgroveb MP, Jay M, Sripanidkulchaia B (2013). Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-cyclodextrin. International Journal of Pharmaceutics 445: 1-11.

Negi LM, Tariq M, Talegaonkar S (2013). Nano scale self-emulsifying oil based carrier system for improved oral bioavailability of camptothecin derivative by P-Glycoprotein modulation. Colloids and Surfaces B: Bio interfaces 111: 346- 353.

Nekanti V, Kalepu S (2012). Development of novel lipid based drug delivery system for raloxifene hydrochloride. International Research J Pharmacy 3:9.

Nguyen TH, Tan A, Santos L, Ngo D, Edwards GA, Porter CJ, Prestidge CA, Boyd BJ (2013). Silica-lipid hybrid (SLH) formulations enhance the oral bioavailability and efficacy of celecoxib: An in vivo evaluation. Journal of Controlled Release167: 85-91.

Niederquella A, Volker AC, Kuentza M (2012). Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with respect to liquid filling of capsules. International Journal of Pharmaceutics 426: 144-152.

Nigade PM, Patil SL, Tiwari SS (2012). Self-Emulsifying Drug Delivery System (Sedds): A Review.IJPP 2: 42-52.

Nkansah P, Antipas A, Lu Y, Varma M, Rotter C, Rago B, El-Kattan A, Taylor G, Rubio M, Litchfield J (2013). Development and evaluation of novel solid nanodispersion system for oral delivery of poorly water-soluble drugs. Journal of Controlled Release 169: 150-161.

Onoue S, Uchida A, Kuriyama K (2012). Novel solid self-emulsifying drug delivery system of coenzyme Q10 with improved photochemical and pharmacokinetic behaviors. European Journal of Pharmaceutical Sciences 46: 492-499.

Palmieri G, Bonacucina G, Cespi M, Mencarelli G, Casettari L, (2013). The use of acoustic spectroscopy in the characterization of ternary phase diagrams. International Journal of Pharmaceutics 441: 603-610.

Park MJ, Balakrishnan P, Yang SG (2013). Polymeric nanocapsules with SEDDS oil-core for the controlled and enhanced oral absorption of cyclosporine. International Journal of Pharmaceutics 441: 757-764.

Patel MJ, Patel SS, Patel NM, Patel MM (2010). A Self-Microemulsifying Drug Delivery System (SMEDDS). ISSN 4:29-35.

Patel PA, Chaulang GM, Akolkotkar A, et al., (2008). Self Emulsifying Drug Delivery System: A Review. Research J. Pharm. and Tech 4-8.

Patel S, Patel D, Patel C, Patel T, Prajapati P, Parikh B (2010). Self-Emulsifying Drug Delivery System. Journal of Global Pharma Technology 2:2.

Piorkowski DT, Clements DJ (2013). Beverage Emulsions: Recent Developments in Formulation, Production, and Applications. Food Hydrocolloid 007:09.

Pouton C.W (1997). Formulation of self-emulsifying drug delivery systems. Advanced Drug Delivery Reviews 25: 47-58.

Seoa Y, DaeH K, Ramasamya T, Jeong HK, Nirmal M, Yu-KO, Dong-WK, Jin KK, Chul SY, Jong K, Han-Gon C (2013). Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect. International Journal of Pharmaceutics 452: 412-420.

Singh B, Singh R, Bandyopadhyaya S, Kapila R, Garga B (2013). Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol. Colloids and Surfaces B: Biointerfaces 101: 465-474.

Stillhart C, Kuentza M (2012). Comparison of high-resolution ultrasonic resonator technology and Raman spectroscopy as novel process analytical tools for drug quantification in self-emulsifying drug delivery systems. Journal of Pharmaceutical and Biomedical Analysis 59: 29-37.

Villar A, Naverosb B, Calpena A (2012). Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil. Int J Pharmaceutics 431: 161-175.

Wei Y, Ye X, Shang X (2012). Enhanced oral bioavailability of silybin by a supersaturatable self-emulsifying drug delivery system (S-SEDDS). Colloids and Surfaces A: Physicochemical and Engineering Aspects 396: 22-28.

Yang Y, Clement D (2013). Encapsulation of vitamin E in edible emulsions fabricated using a natural surfactant. Food Hydrocolloids 30:712-720.