Formulation and Evaluation of Fast Dissolving Gliclazide Tablets by Complexation with Hydroxypropyl-β-Cyclodextrin

DOI:

https://doi.org/10.37285/ijpsn.2014.7.1.13

Authors

  • Adel M Aly
  • Khaled M. Al-Akhali
  • Hesham Alrefaey
  • Mahmoud A. Shaker

Abstract



Gliclazide (GZ) is practically insoluble in water and its bioavailability is limited by dissolution rate. The aim of the present study was to enhance the dissolution rate and bioavailability of GZ by complexation with hydroxypropyl (HP)-β-cyclodextrin (CD) applying three different methods; physical mixing, kneading technique and spray drying technique.  Also, to evaluate the dissolution rate and the hypoglycemic effect of the prepared complexes, in comparison with the GZ market product (Glizide tablets) in Saudi market. The produced complexes were characterized and evaluated using Differential Scanning Calorimetry (DSC), X-ray Diffractometry (XRD), Scanning Electron Microscope (SEM) and the in vitro release studies. All the methods of preparation of complexes were found to be effective in improving the solubility of gliclazide in comparison with the commercial product (Glizide tablets). The formation of inclusion complexes was evident in these formulations as shown by DSC and XRD studies. The inclusion complexes prepared by spray drying method in 1:1 molar ratios were the most effective method for improving the solubility of GZ. The in-vivo hypoglycemic effect of the complexed GZ-HP-β-CD prepared by spray drying significantly improved the biological performance and therapeutic efficacy of the drug compared to Glizide market product.

 

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Keywords:

Gliclazide-Hydroxypropyl-β-Cyclodextrin, Complexation, hypoglycemic effect.

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Published

2014-02-28

How to Cite

1.
Aly AM, Al-Akhali KM, Alrefaey H, Shaker MA. Formulation and Evaluation of Fast Dissolving Gliclazide Tablets by Complexation with Hydroxypropyl-β-Cyclodextrin. Scopus Indexed [Internet]. 2014 Feb. 28 [cited 2024 Dec. 10];7(1):2399-405. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/706

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Research Articles

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