Development of Solid-Self Micron Emulsifying Drug Delivery Systems



  • Preethi Sudheer
  • Koushik Y
  • Satish P
  • Uma Shankar M S
  • R S Thakur


As a consequence of modern drug discovery techniques, there has been a steady increase in the number of new pharmacologically active lipophilic compounds that are poorly water soluble and solubility is one of the most important parameter to achieve desired concentration of drug in systemic circulation for therapeutic response. It is a great challenge for pharmaceutical scientist to convert those molecules into orally administered formulation with sufficient bioavailability.  Among the several approaches to improve oral bioavailability of these molecules, Self-micron emulsifying drug delivery system (SMEDDS) is one of the approaches usually used to improve the bioavailability of hydrophobic drugs. However, conventional SMEDDS are mostly prepared in a liquid form, which can have several disadvantages. Accordingly, solid SMEDDS (S-SMEDDS) prepared by solidification of liquid/semisolid self-micron emulsifying (SME) ingredients into powders have gained popularity. This article provides an overview of the recent advancements in S-SMEDDS such as methodology, techniques and future research directions.


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Solid-Self Micron Emulsifying System, Solidification Techniques, Recent Advances and Future aspects




How to Cite

Sudheer P, Y K, P S, M S US, Thakur RS. Development of Solid-Self Micron Emulsifying Drug Delivery Systems. Scopus Indexed [Internet]. 2013 Aug. 31 [cited 2024 Jun. 16];6(2):2014-21. Available from:



Review Articles


Abdalla A and Mader K (2007). Preparation and characterization of a selfemulsifying pellet formulation. Eur J Pharm Biopharm 66: 220-226.

Attama AA (2003). The use of solid self-emulsifying systems in the delivery of diclofenac. Int J Pharm 262: 23-28.

Attama AA and Mpamaugo VE (2006). Pharmacodynamics of piroxicam from self-emulsifying lipospheres formulated with homolipids extracted from Capra hircus. Drug Deliv 13: 133-137.

Bamba J et al(1995). Cryoprotection of emulsions in freeze-drying: freezing process analysis. Drug Dev Ind Pharm 21: 1749-1760.

Caliph S (2000). Effect of short-, medium- and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and noncannulated rats. J Pharm Sci 89: 1073-1084.

Chae GS (2005). Enhancement of the stability of BCNU using self-emulsifying drug delivery systems (SEDDS) and in vitro antitumor activity of self-emulsified BCNU-loaded PLGA wafer. Int J Pharm 301: 6-14.

Christensen KL (2001). Technical optimization of redispersible dry emulsions. Int J Pharm 212: 195-202.

Constantinides PP (1995). Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm 12: 1561-1572.

Gandhi R (1999). Extrusion and spheronization in the development of oral controlled-release dosage forms. PSTT 2: 160-170.

Gao P (2003). Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J Pharm Sci 92: 2386-2398.

Gao P and Morozowich W(2006). Development of supersaturatable selfemulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs. Expert Opin Drug Discov 3: 97-110.

Gupta MK (2001). Enhanced drug dissolution and bulk properties of solid dispersions granulated with a surface adsorbent. Pharm Dev Technol 6: 563-572.

Gupta MK (2002). Hydrogen bonding with adsorbent during storage governs drug dissolution from solid-dispersion granules. Pharm Res 19: 1663-1672.

Gursoy RN and Benita S (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 58: 173-182.

Hansen T (2004). Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid. Int J Pharm 287: 55-66.

Hauss DJ(1998). Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor. J Pharm Sci 87: 164-169.

Hoar TP and Shulman JH (1943). University of Cambridge Nobel Laureates. Nature (London) 152: 102–103.

Iosio T (2008). Bi-layered self-emulsifying pellets prepared by co-extrusion and spheronization: influence of formulation variables and preliminary study on the in vivo absorption. Eur J Pharm Biopharm 69(2): 686-697.

Itoh K(2002). Improvement of physicochemical properties of N-4472 part I: formulation design by using self-microemulsifying system. Int J Pharm 238: 153-160.

Ito Y (2005). Oral solid gentamicin preparation using emulsifier and adsorbent. J Control Release 105: 23-31.

Ito Y (2006). Preparation and evaluation of oral solid heparin using emulsifier and adsorbent for in vitro and in vivo studies. Int J Pharm 317: 114-119.

Jang DJ (2006). Improvement of bioavailability and photostability of amlodipine using redispersible dry emulsion. Eur J Pharm Sci 28: 405-411.

Jannin V (2008). Approaches for the development of solid and semi-solid lipid-based formulations. Adv Drug Deliv Rev 60: 734-746.

Khoo SM (2000). The formulation of halofantrine as either non-solubilising PEG 6000 or solubilising lipid based solid dispersions: physical stability and absolute bioavailability assessment. Int J Pharm 205: 65-78.

Kim JY and Ku YS (2000). Enhanced absorption of indomethacin after oral orrectal administration of a self-emulsifying system containing indomethacin to rats. Int J Pharm 194: 81-89.

Kreilgaard M (2002). Influence of microemulsions on cutaneous drug delivery. Bulletin Technique Gattefosse N(95): 79-100.

Li P (2007). Development and characterization of a solid microemulsion preconcentrate system for oral delivery of poorly water soluble drugs. Controlled Release Society Annual Meeting, Long Beach, CA.

Myers SL and Shively ML(1992). Preparation and characterization of emulsifiable glasses: oil-in-water and water-in-oil-in-water emulsion. J Colloid Interface Sci 149: 271-278.

Newton JM (2001). The influence of formulation variables on the properties of pellets containing a self-emulsifying mixture. J Pharm Sci 90: 987-995.

Newton JM (2005a). Formulation variables on pellets containing selfemulsifying systems. Pharm Tech Eur 17: 29-33.

Newton JM (2005b). The rheological properties of self-emulsifying systems, water and microcrystalline cellulose. Eur J Pharm Sci 26: 176-183.

Palmer AM (2003). New horizons in drug metabolism, pharmacokinetics and drug discovery. Drug News Perspect 16: 57-62.

Prince LM (1974). Microemulsions. Marcel Dekker, New York 144: 77-190.

Serajuddin ATM (1999). Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J Pharm Sci 88: 1058-1066.

Serajuddin ATM (1988). Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersions. J Pharm Sci 77: 414-417.

Seo A (2003). The preparation of agglomerates containing solid dispersions of diazepam by melt agglomeration in a high shear mixer. Int J Pharm 259: 161-171.

Tao Yi, Jiangling Wan, Huibi Xu and Xiangliang Yang (2008). A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. Eur J of Phar and Biopharm 70: 439-444.

Tuleu C (2004). Comparative bioavailability study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone. J Pharm Sci 93: 1495-1502.

Turner SR et al (1985). Acrylamide Copolymers. U. S. Patent 4: 521-580.

Turner SR, Siano DB and Bock J (1985). A Microemulsion Process for Producing Acrylamide-Alkyl Acrylamide Copolymers. U. S. Patent 4: 521-580.

Vasanthavada M and Serajuddin ATM (2007). Lipid-based self-emulsifying solid dispersions. In Oral Lipid-Based Formulations: Enhancing Bioavailability of Poorly Water-Soluble Drugs (Hauss, D.J., ed.). Informa Healthcare 149-184.

Venkatesan N (2005). Liquid filled nanoparticles as a drug delivery tool for protein therapeutics. Biomaterials 26: 7154-7163.

Verreck G and Brewster ME (2004). Melt extrusion-based dosage forms: excipients and processing conditions for pharmaceutical formulations. Bull Tech Gattefosse 97: 85-95.

Wei LL (2007). Investigations of a novel self-emulsifying osmotic pump tablet containing carvedilol. Drug Dev Ind Pharm 33: 990-998.