Synthesis of Novel Azetidinyl-3-(isonicotinamide-yl)-6-iodoquinazolin- 4-ones as Antimicrobial and Antitubercular Agents

DOI:

https://doi.org/10.37285/ijpsn.2012.5.2.9

Authors

  • Jignesh Priyakant Raval
  • Akhaja T N
  • Myangar K N
  • D R Naik

Abstract

A novel new series of 2-[(4'-oxo-3'-chloro-2'-phenylazetidin-1'-yl)-aminomethyl]-3-[N-isonicotinamide-yl]-6-iodo-quinazolin-4-ones were synthesized using the reaction of chloroacetylchloride and appropriate Schiff base. The synthesized compounds were characterized on the basis of their elemental and spectral analysis (IR, 1H-NMR, 13C-NMR and mass spectrometry). All newly synthesized compounds were evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv. They were also tested in vitro for antibacterial activity against selected human pathogens such as E. coli, P. aeruginosa, K. pneumoniae, S. typhi, S. aureus, S. pyogenus, B. subtilis and antifungal activity against C. albicans, A. niger, A. clavatus strains. The selected 6-iodo-quinazolinonones showed promising biological activity and could be useful as antimicrobial agents. 

 

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Keywords:

5-Iodo-Quinazoline-4-one, isonicotinic acid hydrazide, azetidinone, schiff base, antimicrobial activity, antitubercular activity

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Published

2012-08-31

How to Cite

1.
Raval JP, T N A, K N M, Naik DR. Synthesis of Novel Azetidinyl-3-(isonicotinamide-yl)-6-iodoquinazolin- 4-ones as Antimicrobial and Antitubercular Agents. Scopus Indexed [Internet]. 2012 Aug. 31 [cited 2024 May 18];5(2):1735-44. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/579

Issue

Vol. 5 No. 2 (2012): July-September 2012

Section

Research Articles
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Scopus
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Europe PMC

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