Synthesis and Biological Evaluation of Novel 4-Ethyl-3-methyl-N-phenyl-3,4- dihydroquinoxalin-2-amine Derivatives"

DOI:

https://doi.org/10.37285/ijpsn.2010.3.4.12

Authors

  • Ashutosh Kumar Patidar
  • Venkataramana C H S
  • Madhavan V

Abstract

Substituted anilines were reacted with ethyl-2-bromopropionate to give different substituted 2-bromo-N-phenylpropionamides, which were further condensed with o-phenylenediamines to give corresponding 3-methyl-N-phenyl-3,4-dihydroquinoxalin-2-amines. 4-ethyl-3-methyl-N-phenyl-3,4-dihydroquinoxalin-2-amines were synthesized by the N-alkylation of 3-methyl-N-phenyl-3,4

2-bromo-N-phenylpropionamides; 

-dihydroquinoxalin-2-amines using ethyl iodide.

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Keywords:

Substituted anilines, 2-bromo-N-phenylpropionamides;

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Published

2011-02-28

How to Cite

1.
Patidar AK, C H S V, V M. Synthesis and Biological Evaluation of Novel 4-Ethyl-3-methyl-N-phenyl-3,4- dihydroquinoxalin-2-amine Derivatives". Scopus Indexed [Internet]. 2011 Feb. 28 [cited 2024 Oct. 13];3(4):1271-5. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/545

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Section

Research Articles

References

Ganapaty S, Ramalingam P and Rao CB. Antibacterial, antifungal and antitubercular screening of some novel condensed bridgehead nitrogen heterocycles of quinoxalines. Indian. J. Heterocycl. Chem. 16: 283-286 (2007).

Guillon J, Forfar I, Matsuda MM, Desplat V, Saliege M and Thiolat D. Synthesis, analytical behavior and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents. Bioorg. Med. Chem. Lett. 15: 194-210 (2007).

Hassan SY, Khattab SN, Bekhit AA and Amer A. Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors. Bioorg. Med. Chem. Lett. 16(6): 1753-56 (2006).

Hui X, Desrivot J, Bories C, Loiseau PM, Franck X and Hocquemiller R. Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines. Bioorg. Med. Chem. Lett. 16(4): 815-820 (2006)

Pelczar MJ Jr, Chan ECS and Krieg NR. Microbiology, 5th Edition, Tata McGraw Publishing Company Limited, New Delhi, 2004, pp.100-114, 344.

Ramaiah K, Dubey PK, Rao DE, Ramanatham J and Kumar R. Synthesis and spectral properties of a variety of 2-styrylbenzimidazoles. Indian. J. Chem. 39B: 904-914 (2000).

Srinivas C, Kumar CNSP, Rao VJ and Palaniappan S. Green approach for the synthesis of quinoxaline derivatives in water medium using reusable polyanilinesulfate salt catalyst and sodium laurylsulfate. Catal. Lett. 121: 291-296 (2008).

Tandon VK, Yadav DB, Maurya HK, Chaturvedi AK and Shukla PK. Design, synthesis and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents. Bioorg. Med. Chem. 14: 6120-1626 (2006).

Wright WB. Alkylation of amines by esters and lithium aluminium hydride. J. Org. Chem. 27: 1042-45 (1962).