Formulation and Evaluation of Directly Compressible Agglomerates of Celecoxib
DOI:
https://doi.org/10.37285/ijpsn.2010.3.4.4Abstract
Prepared spherical crystals of Celecoxib to increase the compressible properties, dissolution rate and bioavailability, using hydrophilic polymers such as PEG-4000, sod.CMC, sod.alginate and PVP K-30. All the formulations were characterized for micromeritic properties, Drug loading, solubility, in vitro drug release and mean dissolutiom time (MDT). New formulations showed higher dissolution rates and less MDT values than the pure celecoxib. Among all, the crystals prepared with 10 % w/v PVP K-30 exhibited maximum dissolution rate (2.95±0.23%) and very less MDT values (18.50 ± 4.01 min). Hence it was considered as optimized formulation.
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Keywords:
Celecoxib, Compressibility, Flow properties, Hydrophilic polymers, MDT
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