Effect of Tablet Surface Area and Surface Area/Volume on Drug Release from Lamivudine Extended Release Matrix Tablets

DOI:

https://doi.org/10.37285/ijpsn.2010.3.1.11

Authors

  • Narayana Raju P
  • Prakash K
  • Rama Rao T
  • B.C.S. Reddy
  • Sreenivasulu V
  • Lakshmi Narasu M

Abstract

The purpose of this study was to investigate the influence of tablet surface area/ volume (SA/Vol) on drug release from extended-release matrix tablets of lamivudine prepared with hydroxy propyl methylcellulose (HPMC). Highly soluble drug such as lamivudine was utilized in this study to give predominantly diffusion-controlled release. Drug release from HPMC matrix tablets with similar values of SA/Vol was comparable within the same tablet shaped tablet. Tablets having the same surface area but different SA/Vol values did not result in similar drug release, tablets with larger SA/Vol values had faster release profiles. Utility of SA/Vol to affect drug release was demonstrated by changing drug doses, and altering tablet shape to adjust SA/Vol. When SA/Vol was held constant, similar release profiles were obtained. Thus, surface area/volume is one of the key variables in controlling drug release from HPMC matrix tablets. Proper use of this variable has practical application by formulators who may need to duplicate drug release profiles from tablets of different sizes and different shapes.

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Keywords:

Controlled release, Lamivudine matrix tablets, HPMC, Surface area, Surface area/volume ratio

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Published

2010-05-31

How to Cite

1.
P NR, K P, T RR, Reddy B, V S, M LN. Effect of Tablet Surface Area and Surface Area/Volume on Drug Release from Lamivudine Extended Release Matrix Tablets. Scopus Indexed [Internet]. 2010 May 31 [cited 2024 Jul. 15];3(1):872-6. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/479

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Section

Research Articles

References

Huber HE, Dale LB, Christenson GL. Utilization of Hydrophilic Gums for the Control of Drug Release from Tablet Formulations: Disintegration and Dissolution Behavior. J. Pharm. Sci., 55 : 974–976, (1966).

Lapidus H, Lordi NG. Some Factors Affecting the Release of a Water-Soluble Drug from a Compressed hydrophilic Matrix. J. Pharm. Sci. 55: 840–843, (1966).

Alderman DA, A Review of Cellulose Ethers in Hydrophilic Matrices for Oral Controlled-Release Dosage Forms. Int. J. Pharm. Technol. Prod. Manuf. 5 : 1–9, (1984).

Ford JL, Rubinstein MH, Hogan JE, Formulation of Sustained Release Promethazine Hydrochloride Tablets Using Hydroxypropylmethylcellulose Matrixes. Int. J. Pharm. 24 : 327–338, (1985).

Ford JL, Rubinstein MH, McCaul F, Hogan JE, Edgar PJ. Importance of Drug Type, Tablet Shape and Added Diluents on Drug Release Kinetics from Hydroxypropylmethylcellulose Matrix Tablets. Int. J. Pharm. 40:223–234, (1987).

Huber HE, Christenson GL. Utilization of Hydrophilic Gums for the Control of Drug Substance Release from Tablet Formulations. II. Influence of Tablet Hardness and Density on Dissolution Behavior. J. Pharm. Sci. 57: 164–166.( 1968).

Colombo P, Bettini R, Santi P, DeAscentiis A, Peppas NA. Analysis of the Swelling and Release Mechanisms from Drug Delivery Systems with Emphasis on Drug Solubility and Water Transport. J. Contr. Rel., 39: 231–237,( 1996).

Skoug JW, Borin MT, Fleishaker JC, Cooper AM. In Vitro and In Vivo Evaluation of Whole and Half Tablets of Sustained-Release Adinazolam Mesylate. Pharm. Res., 8 , 1482–1488, ( 1991).

Laicher A, Profitlich T. Influence of Tablet Formulation and Size on the In Vitro Sustained- Release Behavior of metoprolol Tartrate from Hydrophilic Matrices. Drug Dev. Ind. Pharm. 21: 1929–1939, (1995).

Cheng K, Zhu J, Song X, Sun L. Studies of Hydroxypropylmethylcellulose Donut-Shaped Tablets. Drug Dev. Ind. Pharm. 25: 1067–1071, (1999).

Karasulu HY, Ertan G, Kose T. Modeling of Theophylline Release from Different Geometrical Erodible Tablets. Eur. J. Pharm. Biopharm.49: 177–182, (2000).

Siepmann J, Kranz H, Peppas NA, Bodmeier R. Calculation of the Required Size and Shape of Hydroxypropyl Methylcellulose Matrices to Achieve Desired Drug Release Profiles. Int. J. Pharm. 201: 151–164, (2000).

Siepmann J, Podual K, Sriwongjanya M, Peppas NA, Bodmeier R. A New Model Describing the Swelling and Drug Release Kinetics from Hydroxypropyl Methylcellulose Tablets. J. Pharm. Sci. 88: 65–72, (1999).

Siepmann J, Kranz H, Peppas NA, Bodmeier R. Calculation of the Required Size and Shape of Hydroxypropyl Methylcellulose Matrices to Achieve Desired Drug Release Profiles. Int. J. Pharm. 201: 151–164, (2000).

Skoug JW, Borin, M T, Fleishaker JC, Cooper AM. In Vitro and In Vivo Evaluation of Whole and Half Tablets of Sustained-Release Adinazolam Mesylate. Pharm. Res, 8 : 1482–1488, (1991)