The Effect of Superdisintegrants on the Dissolution of Promethazine. HCl Fast Dissolving Tablets

DOI:

https://doi.org/10.37285/ijpsn.2010.3.1.10

Authors

  • Ganesh kumar Gudas
  • Manasa B
  • Senthil Kumaran K
  • Rajesham V V
  • Kiran Kumar S
  • Prasanna Kumari J
  • Malla Reddy V

Abstract

Promethazine.HCl is a potent anti-emetic. The central antimuscarinic actions of antihistamines are probably responsible for their anti-emetic effects. Promethazine is also believed to inhibit the medullary chemoreceptor trigger zone, and antagonize apomorphine -induced vomiting. Fast dissolving tablets of Promethazine.HCl were prepared using five superdisintegrants viz; sodium starch glycolate, crospovidone, croscarmellose, L-HPC and pregelatinised starch. The precompression blend was tested for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The tablets were evaluated for weight variation, hardness, friability, disintegration time (1 min), dissolution rate, content uniformity, and were found to be within standard limit. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants. Among the different formulations of Promethazine.HCl was prepared and studied and the formulation S2 containing crospovidone, mannitol and microcrystalline cellulose combination was found to be the fast dissolving formulation. In the present study an attempt has been made to prepare fast dissolving tablets of Promethazine.HCl, by using different superdisintegrants with enhanced disintegration and dissolution rate. 

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Keywords:

Fast dissolving tablets, Promethazine.HCl, Superdisintegrant

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Published

2010-05-31

How to Cite

1.
Gudas G kumar, B M, K SK, V V R, S KK, J PK, et al. The Effect of Superdisintegrants on the Dissolution of Promethazine. HCl Fast Dissolving Tablets. Scopus Indexed [Internet]. 2010 May 31 [cited 2024 Jul. 15];3(1):867-71. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/478

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Section

Research Articles

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