Formulation and In vitro Evaluation of Mucoadhesive Buccal Patches of Ondansetron Hydrochloride

DOI:

https://doi.org/10.37285/ijpsn.2010.3.1.9

Authors

  • Shayeda
  • Sathish Dharani

Abstract

The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of Ondansetron Hydrochloride (OND) which is used for nausea and vomiting associated with cancer chemotherapy and radiotherapy. Permeation of OND was calculated ex vivo using porcine buccal membrane. Buccal films were developed by solvent-casting technique using Hydroxy Propyl Methyl Cellulose(HPMC E15) as mucoadhesive polymer. The patches were evaluated for weight variation, thickness variation, surface pH, moisture absorption, in vitro residence time, mechanical properties, in vitro release, ex vivo permeation studies and drug content uniformity. The formulation F3 was found to give the better results and obeys first order kinetics. 

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Keywords:

Mucoadhesive, Buccal patch, ondansetron hydrochloride, mechanical properties, in vitro studies, ex vivo studies

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Published

2010-05-31

How to Cite

1.
Shayeda, Dharani S. Formulation and In vitro Evaluation of Mucoadhesive Buccal Patches of Ondansetron Hydrochloride. Scopus Indexed [Internet]. 2010 May 31 [cited 2024 Jul. 15];3(1):860-6. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/477

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Research Articles

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