Formulation, Development, Characterization and Solubility Enhancement of Amisulpride

DOI:

https://doi.org/10.37285/ijpsn.2024.17.4.4

Authors

  • S.D Mankar Department of Pharmaceutics, Pravara Rural College of Pharmacy, Loni
  • M. H. Markad Department of Quality Assurance Technique, Pravara Rural College of Pharmacy, Loni
  • S.S. Siddheshwar Department of Pharmaceutics, Pravara Rural College of Pharmacy, Loni
  • A.P Patel Department of Pharmacognosy, Pravara Rural College of Pharmacy, Loni

Abstract

Background: Amisulpride (AMP) is a drug that is poorly water-soluble and is typically characterized by high molecular weights, significant log P values, and low bioavailability. Poor water solubility of a drug is caused by strong intermolecular interaction and a drug's affinity for a lipid environment (lipophilicity). 

Objective: The current study aims to improve Amisulpride's (AMP) oral bioavailability and solubility by developing a complex with 2-hydroxypropyl                             β-cyclodextrin (HP-β-CDT). 

Method: This study describes solubility of AMP with β-CDT and HP-β-CDT. Prepared inclusion complex of AMP and HP-β-CDT by different techniques like physical mixture, kneading and lyophilization. 

Result: A notable improvement in AMP's solubility was obtained with an optimized inclusion complex. The result of FT-IR, DSC and XRD confirms the complex between AMP and HP-β-CDT. The physical mixture, kneading and lyophilization technique, the kneading method is most successful in producing an inclusion complex.

Conclusion: The 1.3 ratio gives the best drug content and dissolution profile.

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Keywords:

Amisulpride (AMP), Inclusion complex, HP-β-CDT, solubility enhancement, bioavailability

Published

2024-08-15

How to Cite

1.
Mankar S, Markad MH, Siddheshwar S, Patel A. Formulation, Development, Characterization and Solubility Enhancement of Amisulpride. Scopus Indexed [Internet]. 2024 Aug. 15 [cited 2024 Nov. 13];17(4):7467-74. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/4291

Issue

Section

Research Articles

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