Design and Characterization of Self-Nanoemulsifying Drug Delivery Systems of Rosuvastatin

DOI:

https://doi.org/10.37285/ijpsn.2018.11.2.6

Authors

  • Bhikshapathi D. V. R. N.
  • Priya Keerthi

Abstract

Development of self-emulsifying drug delivery systems (SEDDS) are becoming more popular to improve the oral bioavailability of poorly water-soluble drugs. Rosuvastatin is a lipid-lowering agent used in patients suffering from dyslipidemia. It is a competitive inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme A, which converts mevalonate to cholesterol. Rosuvastatin is a BCS class II (poor solubility) drug; hence, SNEDDS are being formulated to enhance oral bioavailability of the drug. In the present study, rosuvastatin SNEDDS were formulated using different oils, surfactant and co-surfactant. The optimized formulation F9 has composition of Las (PEG-8-Caprylic glycerides), Maisine 35-1 and Tween 20 as oil phase, surfactant and co-surfactant respectively. Composition of SNEDDS was optimized using Pseudo-ternary phase diagram, where the formulations showed increased self-emulsification with increased concentration of surfactants. Formulation F9 was found to be best formulation based on evaluation parameters. The particle size of the optimized SNEDDS formulation was found to be 10.9 nm & Z-Average of 55.6 nm indicating all the particles were in the nanometer range. The zeta potential of the optimized SNEDDS formulation was found to be -11.2 mV, which comply with the requirement of the zeta potential for stability. The developed rosuvastatin SNEDDS have the potential to minimize the variability in absorption and provide rapid onset of action of the drug. 

 

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Keywords:

SNEDDS, Rosuvastatin, Las (PEG-8-Caprylic glycerides), Maisine 35-1, Tween 20, Pseudo-ternary phase diagram

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Published

2018-03-31

How to Cite

1.
D. V. R. N. B, Keerthi P. Design and Characterization of Self-Nanoemulsifying Drug Delivery Systems of Rosuvastatin. Scopus Indexed [Internet]. 2018 Mar. 31 [cited 2024 Dec. 11];11(2):4042-5. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/362

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Section

Research Articles

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