Synthesis, Characterization and Antidiabetic Activity of Novel Thiazolidine Derivatives

DOI:

https://doi.org/10.37285/ijpsn.2018.11.1.5

Authors

  • Sumeet Prachand
  • Arun K Gupta
  • Ritu Gilhotra

Abstract

Rhodamines are five-member heterocyclic having nitrogen and sulphur atoms in their ring structure respectively and exhibiting potent as well as wide range of pharmacological activities. A series of 4-((4-oxo-2-thioxothiazolidin-5-ylidene) methyl) phenyl substituted benzoate derivatives were synthesized. Benzoic acid derivatives reacted with rhodanine to yield the respective derivatives. This reaction follows the Knoevenagel condensation reaction mechanism by which ethanolamine abstract a proton from heterocyclic ring and a carbanion ion is generated. The structure of synthesize compounds were supported by IR, NMR and mass spectral data. The synthesized compounds were screened for their in vitro antidiabetic activity by α-Amylase, α-Glucosidase inhibition, glucose diffusion inhibitory test and the potential compounds tested for  in vivo activity by blood glucose and body weight changes, serum insulin, Hb, HbA1c, and total protein levels changes, and lipid profiles changes in type 2 diabetic rats.       

 

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Keywords:

Hydantoin, Rhodanine, Knoevenagel condensation, Thiazolidines, Antidiabetic

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Published

2018-01-31

How to Cite

1.
Prachand S, Gupta AK, Gilhotra R. Synthesis, Characterization and Antidiabetic Activity of Novel Thiazolidine Derivatives. Scopus Indexed [Internet]. 2018 Jan. 31 [cited 2024 Oct. 16];11(1):3977-83. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/350

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Research Articles

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