Recent Advancement of Microneedle Technique in Diagnosis and Therapy of Diseases

DOI:

https://doi.org/10.37285/ijpsn.2023.16.4.8

Authors

  • Abhishek Kanugo Department of Pharmaceutics, SVKM NMIMS School of Pharmacy and Technology Management, Shirpur, Dhule

Abstract

The therapeutic efficacy and safety of active ingredients are limited in several dosage forms, especially for those where the skin is the prime application area. Injectable has the potential of high efficacy and bioavailability but needle phobia, painful delivery, inflammatory response, and non-compliance make them less usable. Microneedle (MN) delivery overcomes almost all the limitations by offering painless self-administration, is highly effective, economical, avoids waste generation, and has high patient compliance. The MN technique is unique and novel for delivering all therapeutic moieties, vaccines, and micro and macromolecular drugs. The MN delivery is based on the mechanism of poke and patch, coat and patch, poke and release, poke and flow. The several types of MN utilized are solid, coated, hollow, dissolving, and hydrogel-forming microneedles. The materials fabricating MNs are mainly non-degradable (metals, PVP, PVA, etc.) and degradable (natural, PLGA, PAMA, etc.). MN delivery finds significant application in diagnosing several diseases by collecting blood samples and biological fluids with minimal pain.

Moreover, the tremendous significance of the MN technique is observed in vaccines, hormones, proteins, peptides, psoriasis, ocular diseases, rheumatoid arthritis, malaria, gene delivery, and cosmetics. The delivery of several kinds of injections in cancer therapy is also harrowing. MN delivery worked excellently by delivering immunotherapeutic, immune checkpoint suppressors, photothermal therapy, and photodynamic therapy and thus valuable for targeting cancer with high success and minimal toxicity.

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Keywords:

Microneedle, drug delivery, cancer, vaccine, diagnosis, gene delivery, rheumatoid arthritis

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Published

2023-07-31

How to Cite

1.
Kanugo A. Recent Advancement of Microneedle Technique in Diagnosis and Therapy of Diseases. Scopus Indexed [Internet]. 2023 Jul. 31 [cited 2024 Dec. 11];16(4):6907-20. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/3224

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Review Articles

References

Yang J, Zhang H, Hu T, Xu C, Jiang L, Shrike Zhang Y, et al. Recent advances of microneedles used towards stimuli-responsive drug delivery, disease theranostics, and bioinspired applications. Chem Eng J [Internet]. 2021;426(May):130561. Available from: https://doi.org/10.1016/j.cej.2021.130561

Sabri AH, Kim Y, Marlow M, Scurr DJ, Segal J, Banga AK, et al. Intradermal and transdermal drug delivery using microneedles – Fabrication, performance evaluation and application to lymphatic delivery. Adv Drug Deliv Rev [Internet]. 2020;153:195–215. Available from: https://doi.org/10.1016/j.addr.2019.10.004

Chaturvedi S, Garg A. An insight into techniques for assessing permeation flux across the skin for optimization of topical and transdermal drug delivery systems: "Modelling the topical and transdermal drug delivery systems." J Drug Deliv Sci Technol [Internet]. 2021;62(September 2020):102355. Available from: https://doi.org/10.1016/j.jddst.2021.102355

Moniz T, Costa Lima SA, Reis S. Marine polymeric microneedles for transdermal drug delivery. Carbohydr Polym. 2021;266(April):118098.

Waghule T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M, et al. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomed Pharmacother [Internet]. 2019;109(September 2018):1249–58. Available from: https://doi.org/10.1016/j.biopha.2018.10.078

Gorantla S, Dabholkar N, Sharma S, Rapalli VK, Alexander A, Singhvi G. Chitosan-based microneedles as a potential platform for drug delivery through the skin: Trends and regulatory aspects. Int J Biol Macromol [Internet]. 2021;184(June):438–53. Available from: https://doi.org/10.1016/j.ijbiomac.2021.06.059

Iliescu FS, Iliescu FS, Dumitrescu-Ionescu D, Petrescu M, Iliescu C. A Review on Transdermal Drug Delivery Using Microneedles: Current Research and Perspective Controlled self-assembly View project Microfluidics View project A REVIEW ON TRANSDERMAL DRUG DELIVERY USING MICRONEEDLES: CURRENT RESEARCH AND PERSPECTIVE. Ann Acad Rom Sci Ser Sci Technol Inf [Internet]. 2014;(November). Available from: https://www.researchgate.net/publication/268221237

Amarnani R, Shende P. Microneedles in diagnostic, treatment and theranostics: An advancement in minimally-invasive delivery system. Biomed Microdevices [Internet]. 2022;24(1):1–12. Available from: https://doi.org/10.1007/s10544-021-00604-w

Guillot AJ, Cordeiro AS, Donnelly RF, Montesinos MC, Garrigues TM, Melero A. Microneedle‐based delivery: An overview of current applications and trends. Pharmaceutics. 2020;12(6):1–28.

Nguyen TT, Nguyen TTD, Tran NMA, Vo G Van. Advances of microneedles in hormone delivery. Biomed Pharmacother [Internet]. 2022;145(October 2021):112393. Available from: https://doi.org/10.1016/j.biopha.2021.112393

Dabholkar N, Gorantla S, Waghule T, Rapalli VK, Kothuru A, Goel S, et al. Biodegradable microneedles fabricated with carbohydrates and proteins: Revolutionary approach for transdermal drug delivery. Int J Biol Macromol [Internet]. 2021;170:602–21. Available from: https://doi.org/10.1016/j.ijbiomac.2020.12.177

Nagarkar R, Singh M, Nguyen HX, Jonnalagadda S. A review of recent advances in microneedle technology for transdermal drug delivery. J Drug Deliv Sci Technol. 2020 Oct 1;59:101923.

Xue P, Zhang L, Xu Z, Yan J, Gu Z, Kang Y. Blood sampling using microneedles as a minimally invasive platform for biomedical diagnostics. Appl Mater Today [Internet]. 2018;13:144–57. Available from: https://doi.org/10.1016/j.apmt.2018.08.013

Chinnadayyala SR, park J, Satti AT, Kim D, Cho S. Minimally invasive and continuous glucose monitoring sensor based on non-enzymatic porous platinum black-coated gold microneedles. Electrochim Acta. 2021 Feb 10;369:137691.

Yi K, Wang Y, Shi K, Chi J, Lyu J, Zhao Y. Aptamer-decorated porous microneedles arrays for extraction and detection of skin interstitial fluid biomarkers. Biosens Bioelectron. 2021 Oct 15;190:113404.

Pollard AJ, Bijker EM. A guide to vaccinology: from basic principles to new developments. Nat Rev Immunol 2020 212 [Internet]. 2020 Dec 22 [cited 2022 Jan 12];21(2):83–100. Available from: https://www.nature.com/articles/s41577-020-00479-7

Sidiq KR, Sabir DK, Ali SM, Kodzius R. Does Early Childhood Vaccination Protect Against COVID-19? Front Mol Biosci. 2020 Jun 5;7:120.

Beric-Stojsic B, Kalabalik-Hoganson J, Rizzolo D, Roy S. Childhood Immunization and COVID-19: An Early Narrative Review. Front Public Heal. 2020 Oct 28;8:613.

Sakurai F, Tachibana M, Mizuguchi H. Adenovirus vector-based vaccine for infectious diseases. Drug Metab Pharmacokinet. 2022 Feb 1;42:100432.

Zaimy MA, Saffarzadeh N, Mohammadi A, Pourghadamyari H, Izadi P, Sarli A, et al. New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles. Cancer Gene Ther [Internet]. 2017 Jun 1 [cited 2022 Jan 15];24(6):233–43. Available from: https://pubmed.ncbi.nlm.nih.gov/28574057/

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin [Internet]. 2022;72(1):7–33. Available from: http://www.ncbi.nlm.nih.gov/pubmed/35020204

Kanugo A. Recent Advances of Nanotechnology in the Treatment of Skin Cancer. Curr Pharm Biotechnol [Internet]. 2022 Apr 4 [cited 2022 May 31];23. Available from: https://pubmed.ncbi.nlm.nih.gov/35379144/

Yang J, Liu X, Fu Y, Song Y. Recent advances of microneedles for biomedical applications: drug delivery and beyond. Acta Pharm Sin B [Internet]. 2019;9(3):469–83. Available from: https://doi.org/10.1016/j.apsb.2019.03.007

Vermaelen K. Vaccine strategies to improve anticancer cellular immune responses. Front Immunol. 2019;10(JAN):8.

Sun C, Xu S. Advances in personalized neoantigen vaccines for cancer immunotherapy. Biosci Trends [Internet]. 2020 [cited 2022 Jan 15];14(5):349–53. Available from: https://pubmed.ncbi.nlm.nih.gov/32908077/

Hiller-Sturmhöfel S, Bartke A. The Endocrine System: An Overview. Alcohol Health Res World [Internet]. 1998 [cited 2022 Jan 18];22(3):153. Available from: /pmc/articles/PMC6761896/

Kanugo A, Misra A. New and novel approaches for enhancing the oral absorption and bioavailability of protein and peptides therapeutics [Internet]. Vol. 11, Therapeutic Delivery. Future Medicine Ltd.; 2020 [cited 2021 Mar 18]. p. 713–32. Available from: https://www.future-science.com/doi/abs/10.4155/tde-2020-0068

Lim S, Bae JH, Kwon HS, Nauck MA. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol 2020 171 [Internet]. 2020 Nov 13 [cited 2022 Jan 18];17(1):11–30. Available from: https://www.nature.com/articles/s41574-020-00435-4

Nassar M, Daoud A, Nso N, Medina L, Ghernautan V, Bhangoo H, et al. Diabetes Mellitus and COVID-19: Review Article. Diabetes Metab Syndr Clin Res Rev. 2021 Nov 1;15(6):102268.

Radhakutty A, Stranks JL, Mangelsdorf BL, Drake SM, Roberts GW, Zimmermann AT, et al. Treatment of prednisolone-induced hyperglycaemia in hospitalized patients: Insights from a randomized, controlled study. Diabetes Obes Metab [Internet]. 2017 Apr 1 [cited 2022 Jan 18];19(4):571–8. Available from: https://pubmed.ncbi.nlm.nih.gov/27995731/

Kim WB, Jerome D, Yeung J. Diagnosis and management of psoriasis. Can Fam Physician [Internet]. 2017 Apr 1 [cited 2022 Jan 20];63(4). Available from: https://pubmed.ncbi.nlm.nih.gov/28404701/

Boehncke WH, Schön MP. Psoriasis. Lancet (London, England) [Internet]. 2015 Sep 5 [cited 2022 Jan 20];386(9997):983–94. Available from: https://pubmed.ncbi.nlm.nih.gov/26025581/

Kaushik SB, Lebwohl MG. Psoriasis: Which therapy for which patient: Psoriasis comorbidities and preferred systemic agents. J Am Acad Dermatol [Internet]. 2019 Jan 1 [cited 2022 Jan 20];80(1):27–40. Available from: https://pubmed.ncbi.nlm.nih.gov/30017705/

Shravanth SH, Osmani RAM, L JS, Anupama VP, Rahamathulla M, Gangadharappa H V. Microneedles-based drug delivery for the treatment of psoriasis. J Drug Deliv Sci Technol [Internet]. 2021;64(May):102668. Available from: https://doi.org/10.1016/j.jddst.2021.102668

Grän F, Kerstan A, Serfling E, Goebeler M, Muhammad K. Focus: Skin: Current Developments in the Immunology of Psoriasis. Yale J Biol Med [Internet]. 2020 Mar 1 [cited 2022 Jan 20];93(1):97. Available from: /pmc/articles/PMC7087066/

Tokuyama M, Mabuchi T. New Treatment Addressing the Pathogenesis of Psoriasis. Int J Mol Sci [Internet]. 2020 Oct 2 [cited 2022 Jan 20];21(20):1–16. Available from: https://pubmed.ncbi.nlm.nih.gov/33050592/

Fernandes AR, Sanchez-Lopez E, Santos T dos, Garcia ML, Silva AM, Souto EB. Development and Characterization of Nanoemulsions for Ophthalmic Applications: Role of Cationic Surfactants. Materials (Basel) [Internet]. 2021 Dec 8 [cited 2022 Jan 27];14(24):7541. Available from: /pmc/articles/PMC8706710/

Kang-Mieler JJ, Rudeen KM, Liu W, Mieler WF. Advances in ocular drug delivery systems. Eye [Internet]. 2020;34(8):1371–9. Available from: http://dx.doi.org/10.1038/s41433-020-0809-0

Jiang Q, Wang X, Huang E, Wang Q, Wen C, Yang G, et al. Inflammasome and Its Therapeutic Targeting in Rheumatoid Arthritis. Front Immunol [Internet]. 2022 Jan 13 [cited 2022 Feb 1];12. Available from: https://pubmed.ncbi.nlm.nih.gov/35095918/

Debreova M, Culenova M, Smolinska V, Nicodemou A, Csobonyeiova M, Danisovic L. Rheumatoid arthritis: From synovium biology to cell-based therapy. Cytotherapy [Internet]. 2022 Jan [cited 2022 Feb 1]; Available from: https://pubmed.ncbi.nlm.nih.gov/35090806/

Behl T, Chadha S, Sehgal A, Singh S, Sharma N, Kaur R, et al. Exploring the role of cathepsin in rheumatoid arthritis. Saudi J Biol Sci. 2022 Jan 1;29(1):402–10.

Huang W, Li X, Huang C, Tang Y, Zhou Q, Chen W. LncRNAs and Rheumatoid Arthritis: From Identifying Mechanisms to Clinical Investigation. Front Immunol [Internet]. 2022 Jan 11 [cited 2022 Feb 1];12. Available from: https://pubmed.ncbi.nlm.nih.gov/35087527/

Padyukov L. Genetics of rheumatoid arthritis. Semin Immunopathol [Internet]. 2022 Jan 27 [cited 2022 Feb 1]; Available from: https://pubmed.ncbi.nlm.nih.gov/35088123/

Pelechas E, Voulgari P V., Drosos AA. Recent advances in the opioid mu receptor based pharmacotherapy for rheumatoid arthritis. Expert Opin Pharmacother [Internet]. 2020 [cited 2022 Feb 1];21(17):2153–60. Available from: https://pubmed.ncbi.nlm.nih.gov/33135514/

Malaria [Internet]. [cited 2022 Feb 11]. Available from: https://www.who.int/news-room/fact-sheets/detail/malaria

Phillips MA, Burrows JN, Manyando C, Van Huijsduijnen RH, Van Voorhis WC, Wells TNC. Malaria. Nat Rev Dis Prim 2017 31 [Internet]. 2017 Aug 3 [cited 2022 Feb 11];3(1):1–24. Available from: https://www.nature.com/articles/nrdp201750

Nishanth G, Schlüter D. Blood–Brain Barrier in Cerebral Malaria: Pathogenesis and Therapeutic Intervention. Trends Parasitol. 2019 Jul 1;35(7):516–28.

Aschenbrenner DS. Treatment Approved for Severe Malaria. Am J Nurs [Internet]. 2020 Sep 1 [cited 2022 Feb 11];120(9):24. Available from: https://pubmed.ncbi.nlm.nih.gov/32858690/

Sharma S, Gautam RK, Kanugo A, Mishra DK, Kamal MA. Current synopsis on siRNA therapeutics as a novel anti-cancer and antiviral strategy: Progress and challenges. Curr Pharm Biotechnol [Internet]. 2022 May 17 [cited 2022 Sep 1];23. Available from: https://pubmed.ncbi.nlm.nih.gov/35578839/

Zhi D, Yang T, Zhang T, Yang M, Zhang S, Donnelly RF. Microneedles for gene and drug delivery in skin cancer therapy. J Control Release [Internet]. 2021;335(May):158–77. Available from: https://doi.org/10.1016/j.jconrel.2021.05.009

Noh I, Lee K, Rhee YS. Microneedle systems for delivering nucleic acid drugs. J Pharm Investig [Internet]. 2022 [cited 2022 Feb 17];1. Available from: /pmc/articles/PMC8726529/

Li X, Xu Q, Wang J, Zhang P, Wang Y, Ji J. A gene-coated microneedle patch based on industrialized ultrasonic spraying technology with a polycation vector to improve antitumor efficacy. J Mater Chem B [Internet]. 2021 Jul 21 [cited 2022 Feb 17];9(27):5528–36. Available from: https://pubmed.ncbi.nlm.nih.gov/34161403/

Dul M, Stefanidou M, Porta P, Serve J, O’Mahony C, Malissen B, et al. Hydrodynamic gene delivery in human skin using a hollow microneedle device. J Control Release. 2017 Nov 10;265:120–31.

Dalvi M, Kharat P, Thakor P, Bhavana V, Singh SB, Mehra NK. Panorama of dissolving microneedles for transdermal drug delivery. Life Sci [Internet]. 2021;284(July):119877. Available from: https://doi.org/10.1016/j.lfs.2021.119877

Patent Database Search Results: “Microneedle delivery” in US Patent Collection [Internet]. [cited 2022 Mar 23]. Available from: https://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=0&f=S&l=50&TERM1=Microneedle+delivery&FIELD1=&co1=AND&TERM2=&FIELD2=&d=PTXT

Stinson JA, Boopathy A V., Cieslewicz BM, Zhang Y, Hartman NW, Miller DP, et al. Enhancing influenza vaccine immunogenicity and efficacy through infection mimicry using silk microneedles. Vaccine. 2021 Sep 7;39(38):5410–21.

Iwata H, Kakita K, Imafuku K, Takashima S, Haga N, Yamaguchi Y, et al. Safety and dose-sparing effect of Japanese encephalitis vaccine administered by microneedle patch in uninfected, healthy adults (MNA-J): a randomized, partly blinded, active-controlled, phase 1 trial. The Lancet Microbe [Internet]. 2021 Dec 16 [cited 2022 Jan 12]; Available from: https://linkinghub.elsevier.com/retrieve/pii/S266652472100269X

Lee J, van der Maaden K, Gooris G, O’Mahony C, Jiskoot W, Bouwstra J. Engineering of an automated nano-droplet dispensing system for fabrication of antigen-loaded dissolving microneedle arrays. Int J Pharm. 2021 May 1;600:120473.

Kim E, Erdos G, Huang S, Kenniston TW, Balmert SC, Carey CD, et al. Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. EBioMedicine. 2020 May 1;55:102743.

Li Z, He Y, Deng L, Zhang ZR, Lin Y. A fast-dissolving microneedle array loaded with chitosan nanoparticles to evoke systemic immune responses in mice. J Mater Chem B [Internet]. 2020 Jan 2 [cited 2022 Jan 13];8(2):216–25. Available from: https://pubs.rsc.org/en/content/articlehtml/2020/tb/c9tb02061f

Kuwentrai C, Yu J, Rong L, Zhang BZ, Hu YF, Gong HR, et al. Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice. Bioeng Transl Med [Internet]. 2020 Jan 1 [cited 2022 Jan 13];6(1). Available from: https://pubmed.ncbi.nlm.nih.gov/33349797/

Meyer BK, Kendall MAF, Williams DM, Bett AJ, Dubey S, Gentzel RC, et al. Immune response and reactogenicity of an unadjuvanted intradermally delivered human papillomavirus vaccine using a first generation NanopatchTM in rhesus macaques: An exploratory, pre-clinical feasibility assessment. Vaccine X. 2019 Aug 9;2:100030.

Guo Q, Wang C, Zhang Q, Cheng K, Shan W, Wang X, et al. Enhanced cancer immunotherapy by microneedle patch-assisted delivery of HBc VLPs based cancer vaccine. Appl Mater Today. 2021 Sep 1;24:101110.

Fentahun Darge H, Lee C-Y, Lai J-Y, Lin S-Z, Harn H-J, Chen Y-S, et al. Separable double-layered microneedle-based transdermal codelivery of DOX and LPS for synergistic immunochemotherapy of a subcutaneous glioma tumor. Chem Eng J [Internet]. 2021 Dec 10 [cited 2022 Jan 15];134062. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1385894721056369

Hao Y, Chen YW, He XL, Yang F, Han RX, Yang CL, et al. Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy. Bioact Mater [Internet]. 2020;5(3):542–52. Available from: https://doi.org/10.1016/j.bioactmat.2020.04.002

Bhatnagar S, Bankar NG, Kulkarni MV, Venuganti VVK. Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model. Int J Pharm. 2019 Feb 10;556:263–75.

Uddin MJ, Scoutaris N, Economidou SN, Giraud C, Chowdhry BZ, Donnelly RF, et al. 3D printed microneedles for anticancer therapy of skin tumours. Mater Sci Eng C. 2020 Feb 1;107:110248.

Liu T, Jiang G, Song G, Sun Y, Zhang X, Zeng Z. Fabrication of Rapidly Separable Microneedles for Transdermal Delivery of Metformin on Diabetic Rats. J Pharm Sci [Internet]. 2021 Aug 1 [cited 2022 Jan 18];110(8):3004–10. Available from: https://pubmed.ncbi.nlm.nih.gov/33878323/

Lee Y, Li W, Tang J, Schwendeman SP, Prausnitz MR. Immediate detachment of microneedles by interfacial fracture for sustained delivery of a contraceptive hormone in the skin. J Control Release. 2021 Sep 10;337:676–85.

Yao Z, Xue T, Xiong H, Cai C, Liu X, Wu F, et al. Promotion of collagen deposition during skin healing through Smad3/mTOR pathway by parathyroid hormone-loaded microneedle. Mater Sci Eng C. 2021 Feb 1;119:111446.

Altuntaş E, Tekko IA, Vora LK, Kumar N, Brodsky R, Chevallier O, et al. Nestorone nanosuspension-loaded dissolving microneedles array patch: A promising novel approach for “on-demand” hormonal female-controlled peritcoital contraception. Int J Pharm [Internet]. 2022 Feb 1 [cited 2022 Jan 19];614:121422. Available from: https://linkinghub.elsevier.com/retrieve/pii/S037851732101228X

Kim S, Yang H, Eum J, Ma Y, Fakhraei Lahiji S, Jung H. Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity. Biomaterials. 2020 Feb 1;232:119733.

Liang L, Fei WM, Zhao ZQ, Hao YY, Zhang C, Cui Y, et al. Improved imiquimod-induced psoriasis like dermatitis using microneedles in mice. Eur J Pharm Biopharm. 2021 Jul 1;164:20–7.

Jing Q, Ruan H, Li J, Wang Z, Pei L, Hu H, et al. Keratinocyte membrane-mediated nanodelivery system with dissolving microneedles for targeted therapy of skin diseases. Biomaterials. 2021 Nov 1;278:121142.

Zhou P, Chen C, Yue X, Zhang J, Huang C, Zhao S, et al. Strategy for osteoarthritis therapy: Improved the delivery of triptolide using liposome-loaded dissolving microneedle arrays. Int J Pharm. 2021 Nov 20;609:121211.

Cárcamo-Martínez Á, Mallon B, Anjani QK, Domínguez-Robles J, Utomo E, Vora LK, et al. Enhancing intradermal delivery of tofacitinib citrate: Comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays. Int J Pharm. 2021 Jan 25;593:120152.

Du H, Liu P, Zhu J, Lan J, Li Y, Zhang L, et al. Hyaluronic Acid-Based Dissolving Microneedle Patch Loaded with Methotrexate for Improved Treatment of Psoriasis. ACS Appl Mater Interfaces [Internet]. 2019 Nov 20 [cited 2022 Jan 22];11(46):43588–98. Available from: https://pubmed.ncbi.nlm.nih.gov/31651148/

Suriyaamporn P, Opanasopit P, Ngawhirunpat T, Rangsimawong W. Computer-aided rational design for optimally Gantrez® S-97 and hyaluronic acid-based dissolving microneedles as a potential ocular delivery system. J Drug Deliv Sci Technol. 2021 Feb 1;61:102319.

Roy G, Garg P, Venuganti VVK. Microneedle scleral patch for minimally invasive delivery of triamcinolone to the posterior segment of eye. Int J Pharm. 2022 Jan 25;612:121305.

Wu Y, Vora LK, Wang Y, Adrianto MF, Tekko IA, Waite D, et al. Long-acting nanoparticle-loaded bilayer microneedles for protein delivery to the posterior segment of the eye. Eur J Pharm Biopharm. 2021 Aug 1;165:306–18.

Cui M, Zheng M, Wiraja C, Chew SWT, Mishra A, Mayandi V, et al. Ocular Delivery of Predatory Bacteria with Cryomicroneedles Against Eye Infection. Adv Sci (Weinheim, Baden-Wurttemberg, Ger [Internet]. 2021 Nov 1 [cited 2022 Jan 27];8(21). Available from: https://pubmed.ncbi.nlm.nih.gov/34494724/

Park SH, Lee KJ, Kang H, Lee YJ, Lee JY, Kim JH, et al. Single Administration of a Biodegradable, Separable Microneedle Can Substitute for Repeated Application of Eyedrops in the Treatment of Infectious Keratitis. Adv Healthc Mater [Internet]. 2021 Jun 1 [cited 2022 Jan 27];10(11). Available from: https://pubmed.ncbi.nlm.nih.gov/33930253/

Du G, He P, Zhao J, He C, Jiang M, Zhang Z, et al. Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment. J Control Release. 2021 Aug 10;336:537–48.

Song X, Wang Y, Chen H, Jin Y, Wang Z, Lu Y, et al. Dosage-efficacy relationship and pharmacodynamics validation of brucine dissolving microneedles against rheumatoid arthritis. J Drug Deliv Sci Technol. 2021 Jun 1;63:102537.

Hu H, Ruan H, Ruan S, Pei L, Jing Q, Wu T, et al. Acid-responsive PEGylated branching PLGA nanoparticles integrated into dissolving microneedles enhance local treatment of arthritis. Chem Eng J. 2022 Mar 1;431:134196.

Wu C, Cheng J, Li W, Yang L, Dong H, Zhang X. Programmable Polymeric Microneedles for Combined Chemotherapy and Antioxidative Treatment of Rheumatoid Arthritis. ACS Appl Mater Interfaces [Internet]. 2021 Nov 24 [cited 2022 Feb 2];13(46):55559–68. Available from: https://pubmed.ncbi.nlm.nih.gov/34783244/

Li Y, Sun Y, Wei S, Zhang L, Zong S. Development and evaluation of tofacitinib transdermal system for the treatment of rheumatoid arthritis in rats. Drug Dev Ind Pharm [Internet]. 2021 [cited 2022 Feb 2];47(6):878–86. Available from: https://pubmed.ncbi.nlm.nih.gov/33886401/

Yenkoidiok-Douti L, Barillas-Mury C, Jewell CM. Design of dissolvable microneedles for delivery of a PFS47-based malaria transmission-blocking vaccine. ACS Biomater Sci Eng [Internet]. 2021 May 10 [cited 2022 Feb 11];7(5):1854–62. Available from: https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.0c01363

Pawar S, Shende P. 22 factorial design-based biocompatible microneedle arrays containing artemether co-loaded with lumefantrine nanoparticles for transepidermal delivery. Biomed Microdevices 2020 221 [Internet]. 2020 Feb 19 [cited 2022 Feb 11];22(1):1–15. Available from: https://link.springer.com/article/10.1007/s10544-020-0476-8

Ananda PWR, Elim D, Zaman HS, Muslimin W, Tunggeng MGR, Permana AD. Combination of transdermal patches and solid microneedles for improved transdermal delivery of primaquine. Int J Pharm. 2021 Nov 20;609:121204.

Volpe-Zanutto F, Ferreira LT, Permana AD, Kirkby M, Paredes AJ, Vora LK, et al. Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium yoelii. J Control Release. 2021 May 10;333:298–315.

Search of: Microneedle - List Results - ClinicalTrials.gov [Internet]. [cited 2022 Mar 2]. Available from: https://clinicaltrials.gov/ct2/results?cond=Microneedle&term=&cntry=&state=&city=&dist=