Formulation and Evaluation of Chlorpheniramine Maleate Troches

DOI:

https://doi.org/10.37285/ijpsn.2019.12.5.6

Authors

  • Rajitha K
  • Rashmitha G
  • Sharanya B
  • Swathi A

Abstract

The present study was sought to prepare Chlorphenamine (also called chlorpheniramine) maleate troches. Chlorpheni-ramine maleate (CPM) is a first-generation alkyl amine anti histamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticarial having oral bio availability about 25-50%, it undergoes first pass metabolism. Troches containing CPM was prepared by non-aqueous granulation technology using Xanthum gum, Gum acacia, HPMC K4M and tragacanth and guar gum as the polymers.  The effect of varying the concentration of polymer on release of Chlorpheniramine maleate (CPM) from troches was investigated. Differential scanning calorimetry and X-ray powder diffraction spectroscopy were used for physicochemical characterization. Tablets prepared were evaluated for different parameters such as average weight, hardness, Carr’s index, tapped density, friability, disintegration, content uniformity test. All the parameters were found within the specifications. The drug content was estimated by UV spectrophotometer at 261 nm. In vitro drug release studies of troches formulations were performed in artificial saliva pH 6.8 at 37±1oC. Among the all polymers used the highest drug release is shown with xanthum gum due to its less binding capacity. The in vitro release data was subjected to zero order, first order, Higuchi, Korsemeyer-Peppas, Hixon crowell and erosion model in order to establish the drug release mechanism and kinetics of drug release from the lozenge tablets.

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Keywords:

Troches Tablets, Drug release;, Chlorphenamine;, Acacia, Guar gum

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Published

2019-09-30

How to Cite

1.
K R, G R, B S, A S. Formulation and Evaluation of Chlorpheniramine Maleate Troches . Scopus Indexed [Internet]. 2019 Sep. 30 [cited 2024 Dec. 11];12(5):4656-65. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/318

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Section

Research Articles

References

Harris D and Robinson JR (1992). Buccal drug delivery via the mucous membranes of the oral cavity. J Pharm Sci 81(1): 1-9.
Indian Pharmacopoeia (1996). Government of India. Ministry of Health and Family Welfare, Controller of publication, New Delhi; IP Volume 1: 423-424.
Jain NK (1997). Controlled and novel drug delivery. First edition, New Delhi: CBS Publishers, pp-52-81.
Jantzen GM and Robinson JR (1995). Sustained and controlled-release drug delivery systems, in Banker GS, Rhodes CT (Eds.) Modern Pharmaceutics, Third edition, Marcell Dekker, New York, pp-575-609.
Kini R, Rathnanand M et al (2011). Exploring the use of Isomalt as the tooth friendly sugar substitute in the formulation of Salbutamol sulfate compressed tablet lozenges. International Journal of Pharm Tech Research 3(3): 1375-1381.
Lachman L, Libermann HA and Kanig JL (1991). The theory and practice of industrial pharmacy. 3rd ed. Varghese Publishing House, pp-297-301.
Nalla Chandana, Harish Gopinath, Debjit Bhowmik, I Williamkeri, and Thirupathi Reddy A (2013). Modified release dosage forms-A review. Journal of Chemical and Pharmaceutical Sciences 6: 23-32.
Pattanayak D et al (2012). Formulation development and optimization of medicated lozenges for pediatric use. IJPSR 3: 33-45.
Pramod KTM, Shivakumar HG and Desai KG (2004). Oral transmucosal drug delivery systems. Indian Drugs 41(2): 63-67.
Purshotham Rao K et al (2010). Studies on candy based Clotrimazole pediatric tablet lozenges, Journal of Chemical and Pharmaceutical Research 7: 4-56.
Robinson JR and Yang X (2011). Absorption enhancers. In: J. Swarbrick, JC. Encyclopedia of pharmaceutical technology. Marcel Dekker 18: 1-27.
Ross R and Wilson Z (2001). Anatomy & physiology in health and illness. 9th edition, Edited by Anne Waugh and Allison Goraw: Churchill Livingstone Edinburgh Publishers, pp-289-293.
Selly J and Barr P (1999). Controlled drug delivery. Drug Dev Ind Pharm 128: 243-252.
Shojaei HA (1998). Buccal mucosa as a route for systemic drug delivery: A Review. J Pharm Sci 1(1): 15-30.
The United states Pharmacopoeia (2004). USP 27th revision and the national formulary, 22nd edition. The Asian edition 2004.