Enhancement of Nimodipine Solubility by Self-Nano-emulsifying Drug Delivery System

DOI:

https://doi.org/10.37285/ijpsn.2019.12.5.5

Authors

  • Suresh Gande
  • S. Srikanth Reddy
  • Bhikshapathi D. V. R. N.

Abstract

Self-nanoemulsifying drug delivery system (SNEDDS) of Nimodipine was developed with the purpose of improving the bioavailability of the drug. Based on the results of Nimodipine solubility studies Peceol, Transcutol P and PEG 400 were optimized as oil, surfactant and co-surfactant for the formulation and Pseudo ternary plots was constructed by Chemix software. Fifteen formulations of Nimodipine SNEDDS prepared and analyzed for particle size, emulsification time, percentage drug release, percentage transmittance, in vitro drug dissolution studies and thermodynamic stability. The optimized Nimodipine SNEDDS formulation (F13) subjected to drug-excipient compatibility studies by FTIR. They are analyzed for zeta potential, SEM and stability. The particle size of optimized Nimodipine SNEDDS formulation was 25.9 nm, PDI is 0.382 and zeta potential -12.7 mV that are optimal for the stability of emulsion. SEM studies of Nimodipine SNEDDS indicated spherical shape and uniform particle distribution. The drug release of formulation F13 (98.25±4.77%) was higher than pure drug (38.49±3.88%). The stability studies indicated no change in drug content, drug release, emulsifying properties and appearance. Hence a potential SNEDDS formulation of Nimodipine developed with increased dissolution rate, bioavailability and solubility.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

SNEDDS, Nimodipine, Hypertension, Solubility, Paceol

Downloads

Published

2019-09-30

How to Cite

1.
Gande S, Reddy SS, D. V. R. N. B. Enhancement of Nimodipine Solubility by Self-Nano-emulsifying Drug Delivery System. Scopus Indexed [Internet]. 2019 Sep. 30 [cited 2024 Dec. 9];12(5):4648-56. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/317

Issue

Section

Research Articles

References

Abdalla A and Mader K (2007). Preparation and characterization of a self-emulsifying pellet formulation. Eur J Pharm Biopharm 66: 220-226.
Chaudhari P and Bhalerao A (2012). Method validation for spectrophotometric estimation of cilnidipine. Int J Pharm Pharm Sci 4(5): 96-98.
Cheer SM and McClellan K (2001). Manidipine a review of its use in hypertension. Drugs 61(12): 1777-99.
Constantinides PP, Scalart JP, Lancaster C, Marcello J, Marks G, Ellens H and Smith PL (1994). Formulation and Intestinal Absorption Enhancement Evaluation of Water-in-Oil Microemulsions Incorporating Medium-Chain Glycerides. Pharmaceutical Research 11(10): 1385-1390.
Costa P and Sousa Lobo JM (2001). Modelling and comparison of dissolution profiles. Eur J Pharm Sci 13:123-133.
Dixit P, Jain DK and Dumbwani J (2012). Standardization of an ex vivo method for determination of intestinal permeability of drugs using everted rat intestine apparatus. Pharmacol Toxicol Methods 65:13-17.
Kale A, Amit, Patravale and Vandana (2008). Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SNEDDS) of Nimodipine. AAPS Pharm Sci Tech 9(1): 191-6.
Lipinski C (2002). Poor aqueous solubility—an industry wide problem in drug discovery. Am Pharm Rev 5: 82-85.
Nazzal S (2002). Optimization of a self-nanoemulsified tablet dosage form of ubiquinone using response surface methodology: effect of formulation ingredients. Int J Pharm 240:103-114.
Palmer AM (2003). New horizons in drug metabolism, pharmacokinetics and drug discovery. Drug News Perspect 16: 57-62.
Rajinikanth PS, Keat NW and Garg S (2012). Self-nanoemulsifying drug delivery systems of valsartan: Preparation and in-vitro characterization. International Journal of Drug Delivery 4(2): 153-163.
Saritha D, Penjuri SCB and Nagaraju R (2014). Formulation and evaluation of self emulsifying drug delivery system (SNEDDS) of Indomethacin. Int J Res Pharm Sci 4(2):17- 23.
Setthacheewakul S, Mahattanadul S, Phadoongsombut N, Pichayakorn W and Wiwattanaptapee R (2010). Development and Characterization of Solid Self-emulsifying Drug Delivery System of Cilnidipine. Eur J Pharm Biopharma 76: 475-485.
Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK and Ali M (2007). Development and bioavailability assessment of Ramipril nanoemulsion formulation. Eur J Pharm Biopharm 66:227–243.
Sonia A, Rishikesh G and Prajapati S (2016). Self-Microemulsifying Drug Delivery System. Asian J Pharm Clin Res 9(2):33-38.
Surendra S, Roshan I, and Nagori B (2017). Formulation and Evaluation of Self-Emulsifying Drug Delivery System of Etoricoxib. Asian J Pharm Clin Res 10(7) : 367-372.
Talegaonkar S, Mustafa G, Akhter S, and Iqbal ZI (2010). Design and Development of Oral Oil-in-Water Nanoemulsion Formulation Bearing Atorvastatin: In Vitro Assessment, J Disper Sci and Tech 31(5): 690-701.
Tang B, Cheng G, Gu JC, and Xu CH (2008). Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discov Today 13(13-14): 606-12.
Wu X, Xu J, Huang X, and Wen C (2011). Self-micro emulsifying drug delivery system improves curcumin dissolution and bioavailability. Drug Dev Ind Pharm 37: 15-23.

Most read articles by the same author(s)

<< < 1 2