Nanosponges for Poorly Water-soluble Drugs: Recent Advancements, Patents, and Future Prospective

DOI:

https://doi.org/10.37285/ijpsn.2024.17.4.9

Authors

  • Dr. Dilip Ashok Patil Dilip Assistant Professor, HR Patel Institute of Pharmaceutical Education And Research, Shirpur
  • Rupal Jain Rupal HR Patel Institute of Pharmaceutical Education And Research, Shirpur
  • Saurabh Jain HR Patel Institute of Pharmaceutical Education And Research, Shirpur
  • Krunal Borase HR Patel Institute of Pharmaceutical Education And Research, Shirpur
  • Charushila Borse
  • Shubham Badhe
  • Dr. Ganesh B. Patil Ganesh a:1:{s:5:"en_US";s:105:"Professor, HR Patel Institute of Pharmaceutical Education And Research, Shirpur, Dist- Dhule, Maharashtra";}

Abstract

Nanosponges (NS) have emerged as a groundbreaking solution to a myriad of formulation-related challenges in drug delivery. This review aims to provide a thorough understanding for scientists engaged in nanotechnology by exploring the preparation, characterization, and diverse applications of NS. Additionally, we delve into patent information, shedding light on innovative approaches and intellectual property landscapes surrounding Nanosponges technology. The evolution of Nanosponges marks a significant advancement in overcoming formulation obstacles. Resembling small sponges at the scale of viruses, these carriers can be loaded with a wide array of pharmaceuticals. Navigating through the bloodstream, they precisely target specific areas within the body, adhering to surfaces and initiating controlled and predictable drug release. The localized delivery capability of Nanosponges enhances the effectiveness of medications, as they concentrate at designated sites, optimizing therapeutic outcomes. A pivotal characteristic of Nanosponges is their liquid solubility, enabling efficient utilization for drugs with low solubility. The fluidic nature of these systems contributes to their versatility and applicability in addressing challenges associated with poorly soluble medications. Through an exploration of patents, this review offers insights into the intellectual property landscape, revealing innovative strategies, applications, and future directions of Nanosponges in drug delivery. In summary, this comprehensive review amalgamates current scientific knowledge with patent-related information, providing a holistic perspective on Nanosponges. This review becomes a helpful resource for researchers in the dynamic field of nanotechnology and drug delivery by illuminating formulation methodologies, evaluating patent landscapes, and forecasting future developments.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

Poorly water-soluble drugs, Nanosponges, method of preparation, optimization, DOE

Published

2024-08-15

How to Cite

1.
Dilip DDAP, Rupal RJ, Jain S, Borase K, Borse C, Badhe S, et al. Nanosponges for Poorly Water-soluble Drugs: Recent Advancements, Patents, and Future Prospective. Scopus Indexed [Internet]. 2024 Aug. 15 [cited 2024 Oct. 13];17(4):7519-38. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/2874

Issue

Section

Review Articles

References

Abdelfattah, I. and A.J.J.o.E.M. El-Shamy, Review on the escalating imperative of zero liquid discharge (ZLD) technology for sustainable water management and environmental resilience. 2024. 351: p. 119614.

Laffleur, F. and V.J.I.j.o.p. Keckeis, Advances in drug delivery systems: Work in progress still needed? 2020. 590: p. 119912.

Singh, D., G. Soni, and S.J.E.J.P.M.R. Prajapati, Recent advances in nanosponges as drug delivery system: a review. 2016. 3(10): p. 364-71.

Selvamuthukumar, S., et al., Nanosponges: A novel class of drug delivery system-review. 2012. 15(1): p. 103-111.

Uday, B., et al., Recent advances in nanosponges as drug delivery system. 2013. 6(1): p. 1935-1944.

Iravani, S. and R.S.J.A.S. Varma, Nanosponges for water treatment: Progress and challenges. 2022. 12(9): p. 4182.

A Ansari, K., et al., Paclitaxel loaded nanosponges: in-vitro characterization and cytotoxicity study on MCF-7 cell line culture. 2011. 8(2): p. 194-202.

Trotta, F. and A. Mele, Nanosponges: synthesis and applications. 2019: John Wiley & Sons.

Trotta, F., M. Zanetti, and R.J.B.j.o.o.c. Cavalli, Cyclodextrin-based nanosponges as drug carriers. 2012. 8(1): p. 2091-2099.

Kumar, S., R.J.J.o.I.P. Rao, and M. Chemistry, Analytical tools for cyclodextrin nanosponges in pharmaceutical field: A review. 2019. 94: p. 11-30.

Gentili, A.J.J.o.C.A., Cyclodextrin-based sorbents for solid phase extraction. 2020. 1609: p. 460654.

Jadhav, N., et al., Microsponge delivery system: an updated review, current status and future prospects. 2013. 2(6): p. 1097-1110.

Pathak, Y.V., G. Parayil, and J.K. Patel, Sustainable Nanotechnology: Strategies, Products, and Applications. 2022: John Wiley & Sons.

Pandey, P., D. Purohit, and H.J.R.p.o.n. Dureja, Nanosponges–A promising novel drug delivery system. 2018. 12(3): p. 180-191.

Caldera, F., et al., Evolution of cyclodextrin nanosponges. 2017. 531(2): p. 470-479.

Osmani, A.M., et al., Cyclodextrin based nanosponges: impending carters in drug delivery and nanotherapeutics. 2015. 10(1): p. 3-19.

Lukyanov, A.N. and V.P.J.A.d.d.r. Torchilin, Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. 2004. 56(9): p. 1273-1289.

Dubey, P., et al., Formulations and evaluation of Cyclodextrin complexed Ceadroxil loaded nanosponges. 2017. 9(3): p. 84-100.

Patel, P. and A.J.W.j.o.p.s. Deshpande, Patent review on cyclodextrin based nanosponges prepared by different methods: physicochemical characterization, factors influencing formation and applications. 2014: p. 380-385.

Ghurghure, S.M., M.S.A. Pathan, and P.R.J.I.J.C.S. Surwase, Nanosponges: A novel approach for targeted drug delivery system. 2018. 2(2).

Silpa, G., et al., Nanosponges: A potential nanocarrier: A review. 2020. 12(10): p. 1341-1344.

Jain, A., et al., Engineered nanosponges as versatile biodegradable carriers: An insight. 2020. 57: p. 101643.

Swaminathan, S., et al., Nanosponges encapsulating dexamethasone for ocular delivery: formulation design, physicochemical characterization, safety and corneal permeability assessment. 2013. 9(6): p. 998-1007.

Cavalli, R., et al., Cyclodextrin-based nanosponges for drug delivery. 2006. 56: p. 209-213.

Jilsha, G. and V.J.I.J.P.S.R.R. Viswanad, Nanosponges: A novel approach of drug delivery system. 2013. 19(2): p. 119-123.

Patel, M., B. Bhanvase, and S.J.U.s. Sonawane, Production of cerium zinc molybdate nano pigment by innovative ultrasound assisted approach. 2013. 20(3): p. 906-913.

Kumar, A. and R.J.P.B. Rao, Enhancing efficacy and safety of azelaic acid via encapsulation in cyclodextrin nanosponges: Development, characterization and evaluation. 2021. 78: p. 5275-5302.

Pawar, S. and P.J.R.P.o.N. Shende, A comprehensive patent review on β-cyclodextrin cross-linked nanosponges for multiple applications. 2020. 14(1): p. 75-89.

Kumar, P., et al., 18 Nanomaterials and Their. 2020: p. 279.

Anandam, S. and S.J.J.o.P.M. Selvamuthukumar, Optimization of microwave-assisted synthesis of cyclodextrin nanosponges using response surface methodology. 2014. 21: p. 1015-1023.

Peila, R., et al., Synthesis and characterization of β-cyclodextrin nanosponges for N, N-diethyl-meta-toluamide complexation and their application on polyester fabrics. 2017. 119: p. 87-94.

Kiasat, A.R., S.J. Saghanezhad, and S.J.C.O.C. Noori, β-Cyclodextrin based nanosponges in organic synthesis. 2019. 23(21): p. 2366-2377.

Thakre, A., Y. Gholse, and R.J.J.M.P.A.S. Kasliwal, Nanosponges: a novel approach of drug delivery system. 2016. 78(92): p. 78.

Abbas, N., et al., Development and evaluation of scaffold-based nanosponge formulation for controlled drug delivery of naproxen and ibuprofen. 2018. 17(8): p. 1465-1474.

Jain, P.D., et al., “NANOSPONGE: A VERSATILE DRUG DELIVERY SYSTEM”-REVIEW. 2019. 1(11): p. 110-115.

Francis, D.J.E. and F.S.J.U.J.o.P.R. Yusuf, Development and evaluation of nanosponges loaded extended release tablets of lansoprazole. 2019. 4(1): p. 24-28.

Seema, G., S.A. Kumar, and B.J.W.J.P.R. Manoj, Development and evaluation of curcumin loaded nanosponges for colon drug delivery. 2015. 4(5): p. 1650-1666.

Srinivas, P. and K.J.I.J.D.D.R. Sreeja, Formulation and evaluation of voriconazole loaded nanosponges for oral and topical delivery. 2013. 5(1): p. 55-69.

Mendes, C., et al., Cyclodextrin based nanosponge of norfloxacin: Intestinal permeation enhancement and improved antibacterial activity. 2018. 195: p. 586-592.

Soukasene, S., et al., Antitumor activity of peptide amphiphile nanofiber-encapsulated camptothecin. 2011. 5(11): p. 9113-9121.

Swaminathan, S., et al., Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. 2010. 74(2): p. 193-201.

Minelli, R., et al., Antitumor activity of nanosponge-encapsulated Camptotechin in human prostate tumors. 2011. 71(8_Supplement): p. 4431-4431.

Zidan, M.F., et al., In vitro and in vivo evaluation of cyclodextrin-based nanosponges for enhancing oral bioavailability of atorvastatin calcium. 2018. 44(8): p. 1243-1253.

Deshpande, A. and P.J.A.J.P.R. Patel, Preparation and evaluation of cyclodextrin based atorvastatin nanosponges. 2014. 4(3): p. 2249-3387.

Shringirishi, M., et al., Fabrication and characterization of nifedipine loaded β-cyclodextrin nanosponges: An in vitro and in vivo evaluation. 2017. 41: p. 344-350.

Shende, P.K., et al., Influence of different techniques on formulation and comparative characterization of inclusion complexes of ASA with β-cyclodextrin and inclusion complexes of ASA with PMDA cross-linked β-cyclodextrin nanosponges. 2012. 74: p. 447-454.

Kanchana, C., Formulation, Characterization and Evaluation of Nystatin Nanosponge GEL For the Treatment of Candidiasis. 2016, College of Pharmacy Madras Medical College, Chennai.

Sharma, R., R.B. Walker, and K. Pathak, Evaluation of the kinetics and mechanism of drug release from econazole nitrate nanosponge loaded carbapol hydrogel. 2011.

Sharma, R., K.J.P.d. Pathak, and technology, Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation. 2011. 16(4): p. 367-376.

Trotta, F., et al., The application of nanosponges to cancer drug delivery. 2014. 11(6): p. 931-941.

Kaur, G., G. Aggarwal, and S.J.I.G.J.P.S. Harikumar, Nanosponge: New colloidal drug delivery system for topical delivery. 2015. 5: p. 53-7.

Jagtap, S.R., et al., Nanosponges: a novel trend for targeted drug delivery. 2019. 9(3-s): p. 931-938.

Challa, R., et al., Cyclodextrins in drug delivery: an updated review. 2005. 6: p. E329-E357.

Tejashri, G., B. Amrita, and J.J.A.p. Darshana, Cyclodextrin based nanosponges for pharmaceutical use: A review. 2013. 63(3): p. 335-358.

David, F.J.P.D.T., Nanosponge drug delivery system more effective than direct injection. 2011. 16(4): p. 367-376.

Zarzycki, P., H.J.J.o.p. Lamparczyk, and b. analysis, The equilibrium constant of β-cyclodextrin–phenolphtalein complex; influence of temperature and tetrahydrofuran addition. 1998. 18(1-2): p. 165-170.

Jain, A.C. and M.C.J.I.j.o.p. Adeyeye, Hygroscopicity, phase solubility and dissolution of various substituted sulfobutylether β-cyclodextrins (SBE) and danazol–SBE inclusion complexes. 2001. 212(2): p. 177-186.

Ravi, S.C., et al., Nano sponges: A targeted drug delivery system and its applications. 2019. 7(3): p. 040-047.

Kumar, R.S., A.J.J.o.D.D. Bhowmik, and Therapeutics, Nanosponges: Novel Drug Delivery for Treatment of cancer. 2019. 9(4-A): p. 820-825.

Subhash, P.B., S.J.E.J.P.M.R. Mohite, and 206, Formulation design & development of Artesunate Nanosponge. 2016. 211.

Richhariya, N., S.K. Prajapati, and U.K.J.W.J.P.R. Sharma, Nanosponges: an innovative drug delivery system. 2015. 4(7): p. 1751-3.

Embil, K. and S.J.J.o.m. Nacht, The microsponge® delivery system (MDS): a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. 1996. 13(5): p. 575-588.

Sehgal, N.J.A.J.P. and C. Re, N, VG; Kanna, S. A Review On Nanosponges A Review On Nanosponges: A Boon To Targeted Drug Delivery For Anticancer Drug. 2019: p. 1-7.

Gedam, S., G.J.J.o.P.S. Basarkar, and Research, Nanosponges: An attractive strategy for enhanced therapeutic profile. 2019. 11(6): p. 2479-2487.

Abass, M.M. and N.A.J.I.J.o.P.S. Rajab, Preparation and characterization of etodolac as a topical nanosponges hydrogel. 2019. 28(1): p. 64-74.

Shekunov, B.Y., et al., Particle size analysis in pharmaceutics: principles, methods and applications. 2007. 24: p. 203-227.

Cavalli, R., et al., Nanosponge formulations as oxygen delivery systems. 2010. 402(1-2): p. 254-257.

Tambe, R.S., et al., Review on nanosponges: As a targeted drug delivery system. 2015. 5: p. 215-24.

Patel, E., R.J.I.j.o.r.i.p. Oswal, and chemistry, Nanosponge and micro sponges: a novel drug delivery system. 2012. 8: p. 237-244.

Wszelaka-Rylik, M., P.J.J.o.T.A. Gierycz, and Calorimetry, Isothermal titration calorimetry (ITC) study of natural cyclodextrins inclusion complexes with tropane alkaloids. 2015. 121: p. 1359-1364.

Shivani, S., K.K.J.I.j.o.p.s. Poladi, and research, Nanosponges-novel emerging drug delivery system: A review. 2015. 6(2): p. 529.

Ajinkya, K., et al., Scaffold based drug delivery system: A special emphasis on nanosponges. 2015. 3(4): p. 98-104.

Patel, B., et al., An assessment on preparations, characterization, and poles apart appliances of nanosponge. 2014. 6: p. 1898-907.

Solunke, R.S., et al., Formulation and evaluation of gliclazide nanosponges. 2019. 11(6): p. 181-189.

Mane, P.T., B.S. Wakure, and P.S.J.C.D.D. Wakte, Cyclodextrin based nanosponges: a multidimensional drug delivery system and its biomedical applications. 2021. 18(10): p. 1467-1493.

Utzeri, G., et al., Cyclodextrin-based nanosponges: Overview and opportunities. 2022. 10: p. 859406.

Thampi, L., et al., Development and Evaluation of Itraconazole Nanosponges as a Fungi Evacuator–an Optimistic Drug Delivery System. 2021.

Pivato, R.V., et al., β-Cyclodextrin nanosponge hydrogels as drug delivery nanoarchitectonics for multistep drug release kinetics. 2021. 3(12): p. 6562-6571.

Ai, X., et al., Surface glycan modification of cellular nanosponges to promote SARS-CoV-2 inhibition. 2021. 143(42): p. 17615-17621.

Tiwari, K. and S.J.J.o.M.S.M.i.M. Bhattacharya, The ascension of nanosponges as a drug delivery carrier: Preparation, characterization, and applications. 2022. 33(3): p. 28.

Nakhlband, A., et al., Combating atherosclerosis with targeted nanomedicines: recent advances and future prospective. 2018. 8(1): p. 59.

Chilajwar, S.V., et al., Cyclodextrin-based nanosponges: A propitious platform for enhancing drug delivery. 2014. 11(1): p. 111-120.

Srivastava, R. and K.J.E.o.o.d.d. Pathak, Microsponges: a futuristic approach for oral drug delivery. 2012. 9(7): p. 863-878.

Kumar, A., et al., Nanotherapeutics: a novel and powerful approach in modern healthcare system, in Nanotechnology in modern animal biotechnology. 2019, Elsevier. p. 149-161.