Enhancement of Solubility and Dissolution Rate of Lercanidipine Solid Dispersions

DOI:

https://doi.org/10.37285/ijpsn.2019.12.1.8

Authors

  • Ashok Kumar U
  • Suresh Gande

Abstract

Lercanidipine hydrochloride is a BCS class II antihypertensive drug with poor solubility and low bioavailability of about 10%. Solid dispersion preparation through solvent evaporation technique has been proven to enhance the solubility and bioavailability of this drug. In the present study, Kolliwax GMS and Gelucire 44/14 were used in the ratio of 1:3 with SLS and this formula exhibited the highest solubility. Dissolution studies of optimized formulation S20 showed highest drug release of 99.08% at the end of 90 minutes among all formulations. FTIR spectroscopy (FTIR), X-Ray diffraction (XRD) and Scanning electron microscopy (SEM) were used as analytical tools to analyze the optimized formulation. FTIR spectra show that there are few interactions between lercanidipine, Gelucire and Kolliwax GMS. The XRD peaks were absent in final formulation but were present in pure drug. These results suggest the transformation of crystalline drug to amorphous form with increased scope of solubility. Therefore, it is concluded that lercanidipine solid dispersions are one of the promising methods to increase its solubility and bioavailability.  

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Keywords:

Lercanidipine, Hypertension, Gelucire, Kolliwax, Solid dispersions

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Published

2019-01-31

How to Cite

1.
U AK, Gande S. Enhancement of Solubility and Dissolution Rate of Lercanidipine Solid Dispersions . Scopus Indexed [Internet]. 2019 Jan. 31 [cited 2024 May 14];12(1):4412-21. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/286

Issue

Vol. 12 No. 1 (2019): January-February 2019

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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