One-pot Synthesis and Antimicrobial Activities of N-Substituted Pyrazoles from Nitro-olefins and Hydrazones

DOI:

https://doi.org/10.37285/ijpsn.2019.12.1.4

Authors

  • Padmini Thatavarthi

Abstract

The aim of the current work was to synthesize a series of N-monosubstituted pyrazoles by the Michael addition of nitro olefins with N-mono substituted hydrazones. The synthesis was accomplished by taking various aldehydes in the reaction at room temperature for simple hydrazones and reflux for bulky hydrazones. The final products were characterized by detailed spectral analysis using Mass, NMR and IR spectroscopy. The final products were evaluated for their antibacterial and antifungal properties. All the compounds (1-10) showed significant antibacterial properties on both gram-positive and gram-negative bacteria. Interestingly, the selected microbes were found to be highly sensitive for compound 1, 3, 4, 8 and 9. The molecules are also antifungal in nature, they have significant inhibitory effect on the growth of Candida albicans and Aspergillus niger. These results indicate that the prepared pyrazoles can be the leads to the development of antimicrobial agents for deadly infections

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Keywords:

Cyclo-addition reaction, N-substituted hydrazones, N-substituted pyrazoles, antibacterial, antifungal

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Published

2019-01-31

How to Cite

1.
Thatavarthi P. One-pot Synthesis and Antimicrobial Activities of N-Substituted Pyrazoles from Nitro-olefins and Hydrazones. Scopus Indexed [Internet]. 2019 Jan. 31 [cited 2024 Dec. 11];12(1):4381-7. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/279

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Section

Research Articles

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