Optimization of Ethyl Cellulose Microspheres Containing Satranidazole Using 3 power2 Factorial Design

DOI:

https://doi.org/10.37285/ijpsn.2019.12.1.3

Authors

  • Reena Ughreja
  • Rajesh H Parikh

Abstract



Intestinal amoebiasis is an infection of the large intestine caused by microscopic one-celled parasites, Entamoeba histolytica. Intestinal amoebiasis has a worldwide distribution and many drugs are available for the same. For better management of intestinal amoebiasis, satranidazole is a potent drug. For its successful delivery to colon, satranidazole must be protected in gastrointestinal tract and then released later in colon. This delayed drug delivery can be achieved using microspheres of satranidazole. Thus the aim of the study is to prepare a multi-particulate system for colonic delivery of satranidazole for better management of intestinal amoebiasis. It is proposed to formulate satranidazole microspheres using emulsion-solvent evaporation technique with ethyl cellulose as a polymer. Since particle size plays an important role in drug release from microspheres, it was optimized using 32 full factorial design in 2 stage. Prepared microspheres were evaluated for particle size, yield, drug loading, encapsulation efficiency, cumulative percentage release in 10 hrs and 24 hrs. The best batch was selected and further evaluated. The release of drug from best batch was compared with dissolution of pure drug. These results suggest that multi-particulate system of ethyl cellulose microspheres could successfully be utilized for colon delivery of satranidazole for better management of intestinal amoebiasis.     

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Keywords:

Multi-particulate system, Satranidazole, Controlled release, Colon targeting

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Published

2019-01-31

How to Cite

1.
Ughreja R, Parikh RH. Optimization of Ethyl Cellulose Microspheres Containing Satranidazole Using 3 power2 Factorial Design: . Scopus Indexed [Internet]. 2019 Jan. 31 [cited 2024 Dec. 11];12(1):4371-80. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/276

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Section

Research Articles

References

Boulten S (1990). Pharmaceutical Statistics, second ed., Marcel Decker Inc, New York, pp 308-337.
Chandra D, Yadav IK, Jaiswal D, Ghosh N, Singh HP, Mishra A, Bhattacharya A, Bajpai M and Jain DA (2009). Formulation and Evaluation of Satranidazole Microspheres for Colon Targeted Drug Delivery. J. Pharm. Res. 2(7): 1230-1233.
Chandra D, Yadav IK, Singh HP and Jain DA (2012). Design and Development of Satranidazole Microspheres for Colon Targeted Drug Delivery. Int. J. Pharm. Chem. Sci. 1(3): 1161-1167.
Cheu SJ, Chen RRL, Chen PF and Lin WJ (2001). In-vitro modified release of Acyclovir from ethyl cellulose microspheres. J. Microencaps. 18(5): 559 -565.
Choudhury PK and Kar M (2009). Controlled release Metformin hydrochloride microspheres of ethyl cellulose prepared by different methods and study on the polymer affected parameters. J. Microencaps. 26(1): 46-53.
Costa P and Lobo MJS (2001). Modeling and comparison of dissolution profiles. Eur. J. Pharm. Sci. 13: 123-133.
Derle D, Boddu SHS and Magar M (2006). Studies on the Preparation, Characterization and Solubility of β -Cyclodextrin - Satranidazole Inclusion Complexes. Indian J. Pharm. Educ. Res. 40(4): 232-236.
Dubey RR and Parikh RH (2004). Two stage optimization for formulation of chitosan microspheres. AAPS Pharm. Sci. Tech. 5(1): 1-9.
Filipovic-Grcic J, Perissutti B, Moneghini M, Voinovich D, Martinac A and Jalsenjak I (2003). Spray-dried Carbamzepine-loaded chitosan and HPMC microspheres: preparation and characterization. J. Pharm. Pharmacol. 55: 921-931.
Ghorab MM, Zia H and Luzzi LA (1990). Preparation of controlled release anticancer agents I: 5-fluorouracil-ethyl cellulose microspheres. J. Microencaps. 7(4): 447-454.
Jain SK, Jain A, Gupta Y and Ahirwar M (2007). Design and Development of Hydrogel Beads for Targeted Drug Delivery to the Colon. AAPS Pharm. Sci. Tech 8(3): 1-8.
Kumar P and Mishra B (2008). Colon Targeted Drug Delivery Systems - An Overview. Curr. Drug Deliv. 5: 186-198.
Nagarajan K, Gowrishankar R, Arya VP, George T, Nair MD, Shenoy SJ and Sudarsanam V (1992). Nitroimidazoles, Part XXIII--activity of Satranidazole series against anaerobic infections. Indian J. Exp. Biol. 30(3): 193-200.
Pargal A, Rao C, Bhopale KK, Pradhan KS, Masani KB and Kaul CL (1993). Comparative pharmacokinetics and amoebicidal activity of Metronidazole and Satranidazole in the golden hamster, Mesocricetus auratus. J. Antimicrob. Chemother 32: 483-489.
Parikh RH, Parikh JR, Dubey RR, Soni HN and Kapadia KN (2003). Poly (D,L-Lactide-Co-Glycolide) microspheres containing 5-Fluorouracil: Optimization of process parameters. AAPS Pharm. Sci. Tech. 4(2): 1-8.
Rodriguez M, Vila-Jato JL and Torres D (1998). Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. J. Control. Release 55: 67-77.
Shukla PG, Kalidhass B, Shah A and Palaskar DV (2002). Preparation and characterization of microcapsules of water soluble pesticide monocrotophs using polyurethane as carrier material. J. Microencaps. 19(3): 293-304.
Sinha VR and Kumria R (2003). Microbially triggered drug delivery to the colon. Eur. J. Pharm. Sci. 18: 3-18.
Soppimath KS, Kulkarni AR and Aminabhavi TM (2001). Encapsulation of antihypertensive drugs in cellulose-based matrix microspheres: characterization and release kinetics of microspheres and tableted microspheres. J. Microencaps. 18(3): 397-409.
Tamizharasi S, Rathi JC and Rathi V (2008). Formulation and evaluation of pentoxifylline-loaded poly (E- caprolactone) microspheres. Indian J. Pharm. Sci. 70(3): 333-337.
US Pharmacopoeia 27 (2004). NF 22, Asian edition, US Pharmacopeial Convention Inc, Rockville, MD, pp 2724-2725 .