An Overview of Factors Affecting Superdisintegrants Functionalities

DOI:

https://doi.org/10.37285/ijpsn.2019.12.1.1

Authors

  • Jemal Dilebo
  • Tesfaye Gabriel

Abstract

Disintegrants are an essential excipients in solid oral formulations. Superdisintegrants such as croscarmellose sodium, sodium starch glycolate, crospovidone and polacrilin potassium are among excipients added in immediate release and oral dispersible tablet formulations at low concentrations to counteract effects of compression and binder after administration. Hygroscopicity of superdisintegrants facilitates permeation of water into tablet matrix and cross-linkage reduces their solubility in water. This article describes factors which could affect functionality of superdisintegrants such as molecular and physicochemical factors (degree of cross-linkage and substitution, particle size, particle porosity and impurities); formulation and process factors (solubility and hygroscopicity of fillers and/or binders, incompatibility, pH, lubricants, mode of disintegrant addition, granulation, mixer shear rate, compression pressure and reworking) and aging and storage conditions.     

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Keywords:

Superdisintegrant, Sodium starch glycolate, Croscarmellose sodium, Crospovidone, Polacrilin potassium, Disintegration, dissolution

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Published

2019-01-31

How to Cite

1.
Dilebo J, Gabriel T. An Overview of Factors Affecting Superdisintegrants Functionalities. Scopus Indexed [Internet]. 2019 Jan. 31 [cited 2024 Dec. 11];12(1):4355-61. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/270

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Section

Review Articles

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