Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus

DOI:

https://doi.org/10.37285/ijpsn.2020.13.1.2

Authors

  • Malviya V.R.
  • Tawar M.G

Abstract

The objective of the present study was to formulate the oral dispersible film of teneligliptin hydrobromide using Pullulan as a polymer and to evaluate it with the different parameters. The drug-excipients studies were carried out in order to determine any type of incompatibilities by using Fourier transmission infrared spectroscopy (FT-IR). The oral dispersible films were prepared using solvent casting method using Pullulan as a polymer. Propylene glycol was used as a plasticizer. The prepared films were evaluated for the parameters like physical appearance, thickness, folding endurance, In vitro disintegration, mechanical properties, surface pH, drug content uniformity, taste evaluation, in vitro dissolution test and stability study. The T6 formulation was found to be optimized, stable and appropriate in its evaluation parameters than compared to other formulations. The folding endurance was found to be 282 ± 1.59, disintegration time was found to be 05 ± 0.57, thickness was found to be 0.064±0.001, tensile strength was found to be 5.89, the % elongation was found to be 26.08, the maximum percentage drug release was found to be 95.90 % in 30 minutes. The drug content was found to be 99.90 with surface pH of 6.4. In the stability studies of the formulation the product was found to be stable for 90 days. The oral dispersible film is simple to administer and very much effective for the patients and the prepared film of teneligliptin proves to be potential candidate for safe and effective oral dispersible drug delivery.  

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

Solvent casting, Propylene-glycol, Pullulan, Oral Dispersible film, dipeptidyl peptidase-4 inhibitors, Teneligliptin

Downloads

Published

2020-01-31

How to Cite

1.
V.R. M, M.G T. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. Scopus Indexed [Internet]. 2020 Jan. 31 [cited 2024 Dec. 11];13(1):4745-52. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/247

Issue

Section

Research Articles

References

Biswajit, B., Kevin, G and Thimmasetty J (2010). Formulation and evaluation of pimozide buccal mucoadhesive patches. Int J Pharm Sci Nanotechnol 2: 32-41.
Brazel CS and Peppas NA (2000). Modeling of drug release from swellable polymers. European Journal of Pharmaceutics and Biopharmaceutics 49(1): 47-58.
Dahiya M, Saha S and Shahiwala AF (2009). A review on mouth dissolving films. Current Drug Delivery 6(5): 469-476.
Deepthi, A., Reddy, BV and Navaneetha, K (2014). Formulation and evaluation of fast dissolving oral films of zolmitriptan. American Journal of Advanced Drug Delivery 2(2): 153-163.
Dinge A and Nagarsenker M (2008). Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. Aaps Pharm Scitech 9(2): 349-356.
Dixit RP and Puthli SP (2009). Oral strip technology: overview and future potential. Journal of Controlled Release 139(2): 94-107.
El-Kamel AH, Ashri LY and Alsarra IA (2007). Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases. AAPS PharmSciTech, 8(3): E184-E194.
Goudanavar, P. S., Bagali, RS, Patil SM and Chandashkhara S (2010). Formulation and in-vitro evaluation of mucoadhesive buccal films of Glibenclamide. Der Pharmacia Lettre 2(1): 382-7.
Joshua JM, Hari R, Jyothish FK and Surendran SA (2017). Formulation of Propranolol Hydrochloride Oral thin films for Migraine Prophylaxis. Int J Pharm Sci Rev Res 42(1):232-241.
Londhe VY and Umalkar KB (2012). Formulation development and evaluation of fast dissolving film of telmisartan. Indian Journal of Pharmaceutical Sciences 74(2): 122.
Maheswari KM, Devineni PK, Deekonda S, Shaik S, Uppala NP and Nalluri BN (2014). Development and evaluation of mouth dissolving films of amlodipine besylate for enhanced therapeutic efficacy. J Pharm (Cairo) 2014: 520949.
Malviya VR and Colleagues (2019). Preparation and evaluation of zolmitriptan hydrochloride lozenges. J Pharm Res 8(8):624-629.
Mishra, S. K., Garud, N and Singh R (2011). Development and evaluation of mucoadhesive buccal patches of flurbiprofen. Acta Pol Pharm, 68(6): 955-964.
Patil, M., Jani, H., Khoja, S., Pirani, N and Khoja S (2017). A Review on chemistry and pharmacological activity of metformin hydrochloride and teneligliptin hydrobromide hydrate in combined dosage form. Pharma Tutor 5(3): 24-30.
Ramesha Chary, R. B., Vani, G and Rao YM (1999). In vitro and in vivo adhesion testing of mucoadhesive drug delivery systems. Drug Development and Industrial Pharmacy, 25(5): 685-690.
Tayel SA, El Nabarawi, MA, Amin, MM and Abou Ghaly MH (2016). Sumatriptan succinate sublingual fast dissolving thin films: formulation and in vitro / in vivo evaluation. Pharmaceutical Development and Technology 21(3): 328-337.
Visser JC, Dohmen WM, Hinrichs WL, Breitkreutz, J., Frijlink HW and Woerdenbag HJ (2015). Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films. International Journal of Pharmaceutics, 485(1-2): 70-76.