Recent Advances in Antibiotic Hybrids

DOI:

https://doi.org/10.37285/ijpsn.2020.13.1.1

Authors

  • Zaber Unnisa
  • Vijaya Bhargavi M
  • Nagma Begum
  • Sumakanth M

Abstract

Antibiotics are the main stay for the treatment of serious bacterial infections. However, there is great concern about widespread use of antibiotics leading to drug resistance. Hybrid antibiotics were obtained by combining structural genes of antibiotic procedures that do not occur in nature. Few of these substances were more efficacious against pathogenic microorganisms resistant produced by the parent strains. Antibiotic hybrid is defined in this review as a synthetic construct of two or more pharmacophores belonging to an established agent, also we elaborated the developments, concepts & challenges in the future use of antibiotic hybrids. To overcome drug resistance and to extend the spectrum of existing antibiotics, Antibiotic hybrids play an important role as the magic bullet in bacteria. The recent activity in the design and development of dual-action hybrid drugs with a non-cleavable linker & explored newly developed synergistic and antagonistic hybrid compounds to reduce resistance development are discussed. As certain compounds are entering clinical trials, the approach of dual-acting hybrid antibiotics holds significant current promise in overcoming existing resistance mechanisms.  

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Published

2020-01-31

How to Cite

1.
Unnisa Z, M VB, Begum N, M S. Recent Advances in Antibiotic Hybrids. Scopus Indexed [Internet]. 2020 Jan. 31 [cited 2024 Dec. 11];13(1):4731-44. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/246

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Section

Review Articles

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