An Innovative Approach for Development and Evaluation of Nanosized Lamotrigine Loaded Bionanoparticles Using Biopolymer from Fragaria × ananassa Fruit

DOI:

https://doi.org/10.37285/ijpsn.2020.13.4.4

Authors

  • Sushant Kumar
  • Satheesh Madhav N V
  • Anurag Verma
  • Kamla Pathak

Abstract

The purpose of this research was to isolate the smart biopolymer from the fruit pulp of Fragaria × ananassa (garden strawberry). We isolated natural fruit pulp to evaluate the potentiality of biopolymer in delivery of nanosized lamotrigine as an antiepileptic drug. Lamotrigine was nanosized by screening its nano-size particle by UV method. The nanosized lamotrigine was used for preparation of bionanoparticles (LF1-LF8) by sonication method. The isolated biopolymer was characterized for DSC, FTIR, NMR, Mass and Zeta particle size analysis. The obtained results confirm its polymeric nature in different analysis. The prepared bionanoparticles showed the release of lamotrigine in sustained manner over 36 hours. The release kinetic study was done by using the BIT-SOFT 1.12 software and T50% and T80%, r2 were calculated. All the formulation showed more than 99.78% drug release. The In-vitro release study of different formulations showed the % drug release from 90.92% to 99.78%. The different formulations were evaluated for the In-vitro release study and release kinetic was studied. The formulation LF5 was found to be the best formulation having T50% of 17 hours and T80% of 29 hours with r2 value of 0.9925. The best formulation LF5 showed up to 90.925% drug release over 36 hours. According to the release kinetic study, the best-fit model was found to be Koresmayer-Peppas and the mechanism of drug release was found to be anomalous transport. The results obtained from different evaluations like percentage entrapment efficiency, particle size, release study, kinetic studies and stability study revealed that isolated biopolymer has good potentiality to form bionanoparticles and it can be safely used as an alternative to synthetic and semisynthetic polymers for the preparation of lamotrigine loaded stable bionanoparticles

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

Biopolymer, Bionanoparticles, Bionanosuspension, Lamotrigin, Epilepsy, Fragaria × ananassa fruit

Downloads

Published

2020-07-12

How to Cite

1.
Kumar S, N V SM, Verma A, Pathak K. An Innovative Approach for Development and Evaluation of Nanosized Lamotrigine Loaded Bionanoparticles Using Biopolymer from Fragaria × ananassa Fruit. Scopus Indexed [Internet]. 2020 Jul. 12 [cited 2024 May 18];13(4):4990-9. Available from: https://www.ijpsnonline.com/index.php/ijpsn/article/view/1045

Issue

Vol. 13 No. 4 (2020): July-August 2020

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Ahmad N (2012). Biological role of Piper nigrum L. (Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine 2(3): 945-953.

Baichwal MR (1985). Polymer films as drug delivery systems. In: Advances in drug delivery systems. Bombay MSR Foundation 136-147.

Dawood NM (2018). Formulation and characterization of lafutidine nanosuspension for oral drug delivery system. Int J Appl Pharm 10: 20-30.

Kabanov AV and Vinogradov SV (2008). Nanogels as pharmaceutical carriers. In: Multifunctional pharmaceutical nanocarriers, Torchilin V (Ed.). Springer Science, New York, 14: 67-80.

Madhav NVS and Shankar MSU (2011). A novel smart mucoadhesive biomaterial from Lallimantia royalena seed coat. J Science Asia 37: 69-71.

Madhav NVS and Singh K (2017). Smart ungual biopenetrant from the roots of Beta vulgaris. Journal of Applied Pharmaceutical Research 29: 5(2): 21-6.

Madhav NVS and Tangri P (2011). Formulation and evaluation of zidovudine bio-micro dwarfs using a novel bio muco resident from Artocarpus heterophyllus. Int J Pharm Tech Res 3: 169-174.

Madhav NVS and Yadav AP (2013). A novel translabial platform utilizing bioexcipients from Litchi chinensis for the delivery of rosiglitazone maleate. Acta. Pharmaceutica. Sinica, B 3:408-415.

Madhav NVS and Yadav AP (2013). Development and evaluation of novel repaglinide biostrips for translabial delivery. Int. Res. J. Pharm 4:198-202.

Mohanraj VJ and Chen Y (2006). Nanoparticles – A Review. Tropical Journal of Pharmaceutical Research 5: 561-73.

Muller (2001). Nanosuspensions as particulate drug formulation in therapy rationale for development and what we can expect for the future. Adv Drug Delivery 47: 3-19.

Nilani P (2010). Formulation and Evaluation of Polysaccharide Based Biopolymer – an Ecofriendly Alternative for Synthetic Polymer. J Pharm Sci Res 2(3): 178-184.

Ojha A and Madhav NVS (2014). A novel potent muco- bioadhesant polymer from seeds of Ricinus communis. World J. Pharm. Pharmaceut. Sci 3: 2154-2165.

Patsalos PN, Froscher W and Pisani F (2002). The importance of drug interactions in epilepsy therapy. Epilepsia 43: 365-385.

Phillips MA, Gran ML and Peppas NA (2010). Targeted Nano delivery of drugs and diagnostics. Nano Today 5: 143-59.

Rogawski M A and Loscher W (2004). The neurobiology of antiepileptic drugs. Nat. Rev. Neurosci 5: 553-564.

Zhang J (2006). Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants. Int J Pharm 323: 153-63.