Recent Advances in Microspheres Technology for Drug Delivery

DOI:

https://doi.org/10.37285/ijpsn.2015.8.2.2

Authors

  • Navneet Kumar Verma
  • Gulzar Alam
  • Vishwakarma D K
  • J N Mishra
  • Wajahat Ullah Khan
  • Abhay Pratap Singh
  • Asha Roshan

Abstract

Microspheres are the novel drug delivery system. A well considered controlled drug delivery system can overcome some of the problems of predictable therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release approach.        A Microspheres has its drug dispersed throughout the particle i.e., the internal structure is a matrix of drug and polymeric excipients. It is the reliable means to deliver the drug to the target site with specificity, if modified and to maintain the desired concentration at the site of interest without untoward effects. Microspheres are typically free flowing powders consisting of synthetic polymers which are biodegradable in nature. Microspheres are particles between 0.1 and 200 μm in size. Microspheres received much consideration not only for prolonged release, but also for targeting of anticancer drugs to the tumor. Microspheres are spherical microparticles and are used where reliable and expected particle surface area is important. A microsphere has a drug located centrally within the particle, where it is encased within a unique polymeric membrane. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in-vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

Drug delivery systems, Controlled release, Microspheres, Therapeutic efficacy

Downloads

Published

2015-05-31

How to Cite

1.
Verma NK, Alam G, D K V, Mishra JN, Khan WU, Singh AP, et al. Recent Advances in Microspheres Technology for Drug Delivery. Scopus Indexed [Internet]. 2015 May 31 [cited 2024 May 18];8(2):2799-813. Available from: http://www.ijpsnonline.com/index.php/ijpsn/article/view/769

Issue

Vol. 8 No. 2 (2015): April-June 2015

Section

Review Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Acikgoz M, Kas HS, Orman M and Hincal AA (1996). Chitosan Microspheres of Diclofenac Sodium: I. Application of Factorial Design and Evaluation of Release Kinetics. J Microsphere 13: 141-160.

Agusundaram M and Chetty MS (2009). Microsphere as A Novel Drug Delivery System a Review. International Journal of Chem Tech Research 1(3):526-534.

Aphale S, Shinde S, Dhat S, Bagul U and Saluja J (2011). International Journal of Pharma and Bio Sciences. 2(3): 121-131.

Bodmeier R and Chen H (1988). Preparation of Biodegradable Poly(9)-Lactide Microspheres using a Spray-Drying Technique. J. Pharm. Pharmacol. 40: 754-757.

Chaturvedi G and Saha RN (2009). A Review on Microsphere Technology and its Application. BITS. 3: 56-58.

Chowdary KPR and Suri BJ (2003). Permeability of Ethylene Vinyl Accetate Copolymer Microcapsules: Effect of Solvents. Indian Journal of pharmaceutical Sciences. 65(1): 62-66.

Deepa, MK and Karthikeyan, M (2009). Cefpodoxime Proxetil Floating Microspheres: Formulation and in Vitro Evaluation. Iranian Journal of Pharmaceutical Sciences. 5(2): 69-72.

Desai S and Bolton S (1993). A Floating Controlled Release Drug Delivery System: in vitro- in vivo Evaluation. Pharm Res. 10: 1321-1325.

Dey, Suddhasatya, Kumar, Dhiraj, Kumar, D. Sandeep, Srenivas S.A, and V, Rahul (2011). Formulation, Characterization and In-Vitro Evaluation of Floating Microspheres of Nateglinide. International Journal of Pharma and Bio Sciences. 2(1):132-139.

Fischer S, Foreg C, Merkle P.H and Gander B, 2004. Chitosan Coated Plga-Microspheres- A Modular System for Targetting Drug Delivery. European Cells and Materials. 7: 11-12.

Gadad, Anand, Naval, Chirag, Patel, Kunal and Mastiholimat, Vinayak (2011). Formulation and Evaluation of Floating Microspheres of Captopril for Prolonged Gastric Residence Time. Indian Journal of Novel Drug delivery. 3(1): 17-23.

Gholap SB, Banarjee SK, Gaikwad DD, Jadhav SL and Thorat RM (2010). Hollow microsphere: A Review. International Journal of Pharmaceutical Sciences Review and Research. 1: 10-15.

Ghulam M, Mahmood A, Naveed A, Fatima RA (2009). Comparative Study of Various Microencapsulation Techniques. Effect of Polymer Viscosity on Microcapsule Characteristics. 22 (3): 291-300.

Grubel P et al. (1987). Gastric Emptying of Nondigestible Solids in the Fasted Dog. J Pharm Sci. 76: 117 -122.

Hafeli U (2002). Physics and Chemistry Basic of Biotechnology. Focus on Biotechnology. Review. Radioactive Microspheres for Medical Application. 7: 213-248.

Hafeli U (2004). Magnetically modulated therapeutic systems. Int J Pharmaceutics. 277: 19-24.

Joshiphine, L.J. J, Mehul, R.T, Wilson, B, Shahnaz, B. and Bincy, R, 2011. “Formulation and In-Vitro Evaluation of Floating Microspheres of Anti- Retro Viral Drug as a Gastro Retentive Dosage Form”. IJRPC . 3: 223-227.

K, Punitha, Kadhir, S, Ravichandran, V, Umadevi, S.K, Vaijyanthi, V, Padmapriya, S., Kumar and Suresh S (2010). Intragastric Floating Drug Delivery System of Ranitidine Hydrochloride: Formulation and Evaluation. International Journal of Pharmacy and Pharmaceutical Sciences. 2(4): 122-132.

Kalyan Shweta, Sharma and ParmodKumar (2010). Recent Advancement in Chitosan best Formulation and its Pharmaceutical Application. Pelagia Research Library. 1(3): 195-210.

Kannan. K., Karar. K.P, Manavalan R (2009). Formulation and Evaluation of Sustained Release Microspheres of Acetazolamide by Solvent Evaporation Technique. J Pharm Sci Res. 1(1): 36-39.

Kavita Kunchu and Raje Veera Ashwani (2010). Albumin Microspheres: A Unique System as Drug Delivery Carriers for Non Steroidal Anti-Inflammatory Drugs. 5(2): 12-17.

Khan A, Sommer W, Fuxe k and Akhtar S (2000). Sitespecific Administration of Antisense Oligonucleotides using Biodegradable Polymer Microspheres Provides Sustained Delivery and Improved Subcellular Biodistribution in the Neostriatum of the Rat Brain. J Drug Target. 8: 319.

Khar RK and Diwan M (2001). Targeted Delivery of Drugs. in Jain N.K., Advances in Controlled and Novel Drug Delivery. 1st Edition, New Delhi, CBS Publisher. P-452-62.

Kumar S, Nagpal K, Singh, SK, Mishra, DN (2011). Improve Bioavailability Through Floating Microspheres of Lovastatin”, DARU. 19(1): 233-243.

Kumar, Senthil, Jaykar, B, Kavimani, S (2010). Formulation, Characterization and Invitro Evaluation of Floating Microsphere Containing Rabeprazole Sodium. JITPS. 1(6): 274-282.

Li, S.P., Kowalski C.R, Feld K.M, Grim WM (1988). Recent Advances in Microencapsulation Technology and Equipment. Drug Dev Ind Pharm. 14: 353-376.

Lopez CR, Portero A, Vila-Jato, JC and Alonso MJ (1998). Design and Evaluation of Chitosan/Ethylcellulose Mucoadhesive Bilayered Devices for Buccal Drug Delivery. J Control Rel. 8: 55-63.

M.Saravanan, K.Bhaskar, G.Srinivasa Rao and M.D. Dhanaraju (2003). Ibuprofen Loaded Ethylcellulose / Polystyrene Microsphers an Approach to get Prolonged Drug Release with Reduced Burst Effect and Low Ethylcellulose Contant. J Microencapsulation. 20(3): 289 - 02.

Mathew Sam T, Devi Gayathri S, Prasanth VV and Vinod B (2010). Suitability of Factorial Design in Determining the Processing Factors Affecting Entrapment Efficiency of Albumin Microspheres. Journal of Pharmacy Research. 3(5):1172- 1177.

Mathew Sam T., Devi Gayathri S., Prasanth V.V and Vinod B (2008). NSAIDs as Microspheres. The Internet Journal of Pharmacology. 6(1): 233-239.

Mayavanshi, AV and Gajjar SS (2008). Floating Drug Delivery Systems to Increase Gastric Retention of Drugs. Research J Pharm Tech. 1(4): 663-667.

Najmuddin M, Ahmed A, Shelar S, Patel, Khan T( 2010). Floating Microspheres of Ketoprofen: Formulation and Evaluation. International Journal of Pharmacy and Pharmaceutical Sci. 2(l2): 83-87.

Pande, A.V, Nimbalkar, U.A., Dhoka, M.V And Sonawane, P.A. (2011). Floating Microspheres of Cefpodoxime Proxitel: Formilation and Optimization by Factorial Design. IJRPC. 1(3): 222-229.

Parmar Harshad, Bakliwal, Sunil at al.( 2010). Different Method of Evaluation of Mucoadhesive Microsphere. International Journal of Applied Biology and Pharmaceutical Technology. 1(3): 1164-1165.

Parmar, Kunal,Vinodbhai, Dr. M.C. Gohel, Dr. R.K. Parikh, Dr. Shital Bariya, Ms. Rajeshvari, N. Suthar (2011). “Sustained Release Floating Microspheres of Acyclovir: Formulation, Optimization, Characterization and In Vitro Evaluation”, International Journal of Drug Development and Research. 3(1): 0975-9344

Patel A, Ray S, and Sharangat R (2006). In Vitro Evaluation and Optimization of Controlled Release Floating Drug Delivery System of Metformin Hydrochloride. DARU. 14(2): 57 - 64.

Ramington GA (2006). The Science and Practice of Pharmacy. Delhi, India 21st Edition. 1. P-924.

Sangale, Sagar.Balaso., Dr. S. D. Barhate, B.V. Jain and Mrugendra Potdar (2011). Formulation and Evaluation of Floating Felodipine Microsphere. IJPRD 3:19-23.

Saralidze K, Leo H, Koole, Menno L and Knetsch W (2010). Polymeric Microspheres for Medical Applications, Materials. 3: 3357- 3564.

Sarode, S.M, Mittal, M,Ngar, R.M, Shelke, A. D, Shrivastava, B and Vidyasagar G (2011). Formulation and Evaluation of Floating Microspheres of Glipizide”. J. Chem. Pharm Res. 3(3): 775-783.

Semalty, Mona, Yadav, Shikha, and Semalty, Ajay(2010). “Preparation and Characterization of Gastroretentive Floating Microspheres of Ofloxacin Hydrochloride”. International Journal of Pharmaceutical Sciences and Nanotechnology. 3(1).

Shaji J, Poddar A, Iyer S (2009). Brain-Targeted Nasal Clonazepam Microspheres. Indian Journal of pharmaceutical Sciences. 71(6): 715-718.

Shanthi N.C, Dr.Gupta R, Mahato KA (2010). Traditional and Emerging Applications of Microspheres: A Review. International Journal of Pharm Tech Research. 2(1): 675-681.

Sharma, Vaishali, Sigh, Lalit, Sharma and Vijay, (2011). “A Novel Approach to Combat Regional Variability: Floating. Drug Delivery System. 8(2): 44-52.

Shashikant, D., Barhate, Yogesh. S, Rupnar, Rupesh, M, Sonvane, Kapil. R, Pawar, Rahulkumar and Rahane D, “Formulation and Evaluation of Floating Microspheres of Ketorolac Trometamol, International Journal of Pharma Research and Development. 1(9): 940-944.

Singh, Bandana, Kanoujia, Jovita, Pandey, Manisha, Saraf and Shubhini. A (2010). Formulation and Evaluation of Floating Microspheres of Famotidine. International Journal of PharmTech Research. 2(2):1415-1420.

Soni L.M, Kumar M and Namdeo P.K, (2010). Sodium Alginate Microspheres for Extending Drug Release: Formulation and in Vitro Evaluation. International Journal of Drug Delivery. 2(1): 64-68.

Sudha Mani T and Naveen Kumar K (2010). At Preparation and Evaluation of Ethyl Cellulose Microspheres of Ibuprofen for Sustained Drug Delivery. International Journal of Pharma Research and Development. 2(8): 120-121.

Surini S, Anggriani V and Anwar E (2009). Study of Mucoadhesive Microspheres based on Pregelatinsed Cassava Starch Succinate as a New Carrier for Drug Delivery. JMed Sci. 9(6): 249-256.

Thanoo BC, Sunny MC and Jayakrishnan A (1992). Cross-Linked Chitosan Microspheres: Preparation and Evaluation as a Matrix for the Controlled Release of Pharmaceuticals. J Pharm Pharmacol. 44: 283-286.

Varshosaz J, Tabbakhian M and Zahrooni M (2007). Development and Characterization of Floating Microballoons for oral Delivery of Cinnarazine by a Factorial Design. Journal of microencapsulation. 24(3): 253-262.

Venkatesan PC, Manavalan R and Valliappan K (2009). Selection of Better Method for the Preparation of Microspheres by Applying Analytic Hierarchy Process. J Pharm Sci Res. 1(3): 64-78.

Vidgren P, Arppe J, Hakuli T, Laine E and Paronen P (1992). In-vitro Evaluation of Spray Dried Mucoadhesive Microspheres for Nasal Administration Drug Dev. Ind. Pharm. 581-597.

Vyas SP and khar RK (2002). Targeted and Controlled Drug Delivery. Novel Carrier System 1st edition. CBS publication and distributors, New Delhi, pp- 81-121.

Widder, KJ, Senyei AE and Ranney DF (1979). Magnetically Responsive Microspheres and other Carriers for The Biophysical Targeting of Antitumor Agents. Adv. Pharmacol. Chemotherapeutic. P-16,213- 271.

Wilson CG and Washington N (1989). The Stomach: Its Role in Oral Drug Delivery. in: Rubinstein MH, Ed. Physiological Pharmacetical: Biological Barriers to Drug Absorption. Chichester, UK: Ellis Horwood; 47-70.

Yadav AV and Mote HH (2008). Development of Biodegradable Starch Microspheres for Intranasal Delivery. Indian Journal of pharmaceutical Sciences. 70(2):170-174.

Yuveraj Singh Tanwar, Pushpendra Singh Naruka, Garima Rani Ojha (2007). Development and Evaluation of Floating Microspheres of Verpamil Hydrochloride. Brazilian Journal of Pharmaceutical Sciences. 43(4): 529-534.