Formulation and Characterization of Solid Self- Microemulsifying Cefuroxime Axetil Products

DOI:

https://doi.org/10.37285/ijpsn.2014.7.3.9

Authors

  • Satish Puttachari
  • Navanath V. Kalyane
  • Sarbani Duttagupta
  • Koushik Yetukuri

Abstract

The Cefuroxime axetil has been used in treatment of wide range of infections but exhibits poor and variable bioavailability thus it is difficult to establish optimal oral dosage schedule. The purpose of this work was to prepare stable solid self-microemusifying drug delivery system (S-SMEDDS) of cefuroxime to improve the solubility and dissolution. The saturation solubility of drug in oils, solvents, surfactants and co-surfactants were determined and ternary phase diagram was drawn. Based on the results SMEDDS were prepared and characterized for self-emulsification properties and in-vitro dissolution. One of the best SMEDDS formulations was converted to S-SMEDDS by adsorption technique using maltodextrin as adsorbent. SEM of the S-SMEDDS revealed that particles were well separated and were free flowing, characterization by DSC, XRD revealed no interaction between drug and excipients. In-vitro dissolution was rapid and complete and no marked changes in physical and emulsification property were observed on stability. 

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Keywords:

Self-emulsification, Adsorption technique, Scanning electron microscope

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Published

2014-08-31

How to Cite

1.
Puttachari S, Kalyane NV, Duttagupta S, Yetukuri K. Formulation and Characterization of Solid Self- Microemulsifying Cefuroxime Axetil Products. Scopus Indexed [Internet]. 2014 Aug. 31 [cited 2024 May 18];7(3):2567-73. Available from: http://www.ijpsnonline.com/index.php/ijpsn/article/view/739

Issue

Vol. 7 No. 3 (2014): July-September 2014

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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