Formulation and Evaluation of Sumatriptan Succinate Fast Disintegrating Films and Tablets

DOI:

https://doi.org/10.37285/ijpsn.2013.6.2.11

Authors

  • Y. Shravan Kumar
  • R Gowthami
  • Sujitha H
  • Nagaraju T
  • Rajashekar M
  • Murali Krishna Kumar
  • Y. Madhusudhan Rao

Abstract

Sumatriptan succinate is a 5-HT1B/1D receptor agonist which has well established efficacy in treating migraine. The main objective of the study was to formulate Oral Fast Disintegrating Films (ODF) and Oral Fast Disintegrating Tablets (ODT) to achieve a better dissolution rate and further improving the bioavailability of the drug.  ODFs were prepared by solvent casting method using film forming polymers like HPMC – E15,5cps,50cps in different ratios & prepared batches of films were evaluated for the drug content, film thickness, disintegration time  and in vitro dissolution studies. Among the prepared formulation F7 containing HPMC – 50cps (drug: polymer ratios = 1:1) was found to be best formulations which releases 98.2±1.1of the drug within 17±0.02 sec. ODTs prepared by direct compression method using in different concentrations of super-disintegrants. The prepared formulation T12 (combination of disintegrants) containing CP + CCS (6%) was considered to be the best formulation, which releases up to 100±0.38% of the drug in 23±0.75 sec, respectively. Based on these results, it is suggested that ODFs have faster disintegration time and drug release than ODTs.

 

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Keywords:

Oral Fast Disintegrating Films, Oral Fast Disintegrating Tablets, Sumatriptan Succinate, Crospovidone, Croscarmellose sodium, Sodium starch glycollate

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Published

2013-08-31

How to Cite

1.
Kumar YS, Gowthami R, H S, T N, M R, Kumar MK, et al. Formulation and Evaluation of Sumatriptan Succinate Fast Disintegrating Films and Tablets. Scopus Indexed [Internet]. 2013 Aug. 31 [cited 2024 May 18];6(2):2087-96. Available from: http://www.ijpsnonline.com/index.php/ijpsn/article/view/625

Issue

Vol. 6 No. 2 (2013): July-September 2013

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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