Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums



  • S. H. Seyed Mohamed Buhary Buhary
  • Jaganath S
  • Palanichamy S
  • Rajesh m
  • Prabhu C
  • Thanga Thirupathi A


The aim of the study was to formulate and evaluate silymarin controlled release (CR) tablets using natural polymers (xanthan gum and guar gum) CR Tablets of silymarin were prepared by direct compression method at different ratios of 1:0.25, 1:0.5 and 1:0.75 (drug:polymers). The powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. The powder blend showed satisfactory flow properties. The silymarin tablets are evaluated for general appearance, hardness test, friability test, weight variation and drug content estimation. All the tablets passed the tests. The interactions between the drug with highest proportion of polymers were determined by using FTIR studies. The FTIR study reveals that there is no interaction between drug and polymers. The invitro release study was carried out using 900ml of phosphate buffer pH 7.4 for 10 hours using USP type II dissolution apparatus. The results of invitro release studies of CR tablets of silymarin were compared with control (without polymer).


Download data is not yet available.


Metrics Loading ...


Silymarin, Xanthan gum, Guar gum, Controlled release, Direct compression




How to Cite

Buhary SHSMB, S J, S P, m R, C P, A TT. Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums. Scopus Indexed [Internet]. 2011 May 31 [cited 2024 Jun. 20];4(1):1368-72. Available from:



Research Articles


Aulton ME and Wells TI “Pharmaceutics: The science of Dosage form Design”, Churchill Livingstone, London, 1988, pp. 159-161.

British Pharmacopoeia, British Pharmacopeial Commission, London, 2: A-209, A-299 (2000).

Ganesh S, Radhakrishnan M, Ravi M, Prasannakumar D and Kalyani J. Invitro evaluation of the effect of combination of hydrophilic and hydrophobic polymers on controlled release zidovudine matrix tablets. Indian J Pharm Sci. 70: 461-465 (2008).

Maneker NC, Gandhi SD and Joshi. Controlled Drug Delivery system. The Eastern Pharmacist, 43: 41-45 (1999).

Mutalik Srinivas and Hiremath Doddayya. Formulation and evaluation of chitosan matrix tablets of nifedipine. The Eastern Pharmacist, 63: 109-111 (2000).

Pharmacopoeia of India, Ministry of Health and Family Welfare, Govt. of India, Controller of Publications, New Delhi, 736 (1996).

Shah D, Shab Y and Rampradhan M. Development and evaluation of controlled release diltiazem hydrochloride Micro particles using cross – linked polyvinyl alcohol, Drug Dev. Ind. Pharm, 23: 567 – 574 (1997).

Sharma YR, Elementary Organic Spectroscopy Principles and Chemical applications, S.Chand and Co., New Delhi, pp. 65-133 (2005).

Subrahmanyam CVS and Thimmasetty T. Laboratory Manual of Physical Pharmaceutics. Vallabh Prakashan, Delhi, 1st edition, pp. 24, 32 and 46-53 (2002).

Subrahmanyan CVS, Text book of Physical Pharmaceutics, Vallabh Prakashan, Delhi, 1st edition, pp. 215-223 (1998).

Vidyadhara S Rao PR and Prasad JA. Formulation and evaluation of propranolol hydrochloride oral controlled release matrix tablets. Indian J.Pharm. Sci. 66: 188-192 (2004).

Yeole PG, Galgatte Babla IB and Nakhat PD. Design and evaluation of xanthan gum based sustained release matrix tablets of diclofenac sodium. Indian J Pharm Sci. 68: 185-189 (2006).