Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums

DOI:

https://doi.org/10.37285/ijpsn.2011.4.1.9

Authors

  • S. H. Seyed Mohamed Buhary Buhary
  • Jaganath S
  • Palanichamy S
  • Rajesh m
  • Prabhu C
  • Thanga Thirupathi A

Abstract

The aim of the study was to formulate and evaluate silymarin controlled release (CR) tablets using natural polymers (xanthan gum and guar gum) CR Tablets of silymarin were prepared by direct compression method at different ratios of 1:0.25, 1:0.5 and 1:0.75 (drug:polymers). The powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. The powder blend showed satisfactory flow properties. The silymarin tablets are evaluated for general appearance, hardness test, friability test, weight variation and drug content estimation. All the tablets passed the tests. The interactions between the drug with highest proportion of polymers were determined by using FTIR studies. The FTIR study reveals that there is no interaction between drug and polymers. The invitro release study was carried out using 900ml of phosphate buffer pH 7.4 for 10 hours using USP type II dissolution apparatus. The results of invitro release studies of CR tablets of silymarin were compared with control (without polymer).

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Keywords:

Silymarin, Xanthan gum, Guar gum, Controlled release, Direct compression

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Published

2011-05-31

How to Cite

1.
Buhary SHSMB, S J, S P, m R, C P, A TT. Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums. Scopus Indexed [Internet]. 2011 May 31 [cited 2024 Jun. 20];4(1):1368-72. Available from: http://www.ijpsnonline.com/index.php/ijpsn/article/view/414

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Research Articles

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