Development and Characterization of Pomegranate-Based Nanoparticles for Drug Delivery Applications

DOI:

https://doi.org/10.37285/ijpsn.2018.11.1.6

Authors

  • Vinay C H
  • Gulzar Ahmed Mohammed
  • Prakash Goudanavar
  • Ankit Acharya Acharya

Abstract

The main objective of the present work was to prepare pomegranate peel extract based nano particles by chemical complexation method. Ethanolic extracts of pomegranate peel were prepared by using Soxhlet apparatus and evaluated for phyto-chemical constituents. Qualitative analysis showed that pomegranate peel extract showed positive results for alkaloids, anthraquinones, saponins and terpenoids.The percentage moisture content and pH of the extract was found to be 72% and 3.6 respectively. A zeta potential and particle size of prepared nanoparticles was found in the range of -24.6 to– 34.5 mV and 118.6 nm to 231.7 nm, respectively. These range confirms that obtained particles were in nano range, i.e. <500 nm size. SEM results indicated the formation of nanoparticles and were relatively spherical in shape. Energy dispersive spectrometry (EDS) analysis confirms the presence of AgNPs. Further the study will be extended for anti-microbial and wound healing activities.        

 

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Keywords:

Pomegranate peel extract, Qualitative analysis, Nanoparticles, Energy spectrometry

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Published

2018-01-31

How to Cite

1.
C H V, Mohammed GA, Goudanavar P, Acharya AA. Development and Characterization of Pomegranate-Based Nanoparticles for Drug Delivery Applications. Scopus Indexed [Internet]. 2018 Jan. 31 [cited 2024 Apr. 20];11(1):3984-9. Available from: http://www.ijpsnonline.com/index.php/ijpsn/article/view/351

Issue

Vol. 11 No. 1 (2018): January-February 2018

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Acharya A, Ahmed MG, Rao BD and Vinay CH (2016). Ethosomal gel of Lornoxicam. Manipal J Pharma Sci 2(1): 13-20.
Aina VO, Mustapha MB and Mamman OA (2012). Extraction and characterization of pectin from peels of lemon (Citrus limon), grape fruit (Citrus paradisi) and sweet orange (Citrus sinensis). Brit J Pharmacolo Toxicolo. 3(6): 259-62.
Ajmal N, Saraswat K and Sharma V (2016). Synthesis and antibacterial activity of silver nanoparticles from Prunus armeniaca (apricot) fruit peel extract. Bull Env Pharmacol Life Sci. 5(8): 91-94.
Chikdu D, Pal P and Gujar A (2015). Green synthesis and characterization of silver nanoparticles by using Aloe barbadensis and its anti-bacterial. J Glob Biosci. 4(7): 2713-19.
Fadel QJ and Al-Mashhedy LAM (2017). Biosynthesis of silver nanoparticles using peel extract of Raphanus sativus L. Biotechnol Ind J. 13(1): 1-10.
Pande SD, Wagh AS and Bhagure LB (2015). Preparation and evaluation of phytosomes of pomegranate peels. Res J Pharm Tech. 8(4): 416-22.
Santhosh NA, Anto PV and Baby NN (2015). Evaluation on antimicrobial activity of fruit peels of selected citrus species against human pathogenic microorganisms. J Pharm Phyto 4(3): 278-81.
Sreedhar D and Srikanth A (2014). Evaluation of synthesis of silver nanoparticles by chemical technology IJNA 8(1): 25-29.
Thilagavathi T, Renuka R and Priya RS (2016). Bio-Synthesis of silver nanoparticles using punicagranatum(pomegranate) peel extract: a novel approach towards waste utilization. Int J Adv Sci Eng 3(1): 234-236.